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Myelin basic protein and multiple sclerosis
The Italian Journal of Neurological Sciences, 1983Myelin basic protein (BP) has the capacity to induce experimental allergic encephalomyelitis (EAE) in animals as well as to prevent and suppress EAE. Immunoreactive BP or BP fragments appear in cerebrospinal fluid (CSF) in persons with multiple sclerosis in acute disease periods and in individuals with acute damage to central nervous system myelin ...
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Phosphorylation on basic amino acids in myelin basic protein
Biochemical and Biophysical Research Communications, 1976Abstract Isolated rat brain myelin when incubated with γ 32 P labelled ATP yields proteins bearing acid labile, base stable phosphoryl groups. Phosphorylated myelin basic protein can be isolated and degraded with trypsin and pronase to yield principally phosphoarginine and phosphohistidine.
Carl W. Kern +3 more
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1995
Myelin basic protein is a structural protein of the nervous system composed of three structural units joined by double phenylalanine residues. The central unit of this stucture — the B fragment — can be found free within the CSF in cases of demyelination or cerebral damage.
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Myelin basic protein is a structural protein of the nervous system composed of three structural units joined by double phenylalanine residues. The central unit of this stucture — the B fragment — can be found free within the CSF in cases of demyelination or cerebral damage.
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Myelin basic protein interacts with the myelin-specific ganglioside GM4
Brain Research, 1981Demyelinated plaques in multiple sclerosis have decreased amounts of both myelin basic protein and sialosylgalactosylceramide (GM4), a ganglioside specifically localized in myelin and oligodendroglia of the central nervous system. We have found that myelin basic protein is capable of releasing large quantities of entrapped [14C]glucose from ...
Francis X. Decandis +3 more
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Immuno-electron microscopic localization of the encephalitogenic basic protein in myelin.
Immunological Communications, 1973Immuno-electron microscopic studies of the localization of encephalitogenic basic protein demonstrate its presence in the major dense line of the myelin sheath.
R. Herndon, H. Rauch, E. Einstein
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1974
Publisher Summary The A1 protein is a highly specialized protein that subserves its role as a structural protein of myelin, but in addition, provides a focus for immunopathological attack. It belongs to a class of membrane proteins with external location that are polar rather than nonpolar, nonglobular, and easily soluble in aqueous systems upon ...
Jesse J. Jackson +2 more
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Publisher Summary The A1 protein is a highly specialized protein that subserves its role as a structural protein of myelin, but in addition, provides a focus for immunopathological attack. It belongs to a class of membrane proteins with external location that are polar rather than nonpolar, nonglobular, and easily soluble in aqueous systems upon ...
Jesse J. Jackson +2 more
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Interaction of myelin basic protein and proteolipid protein
Journal of Neuroscience Research, 1989AbstractThe interaction of myelin basic protein (MBP) and proteolipid protein (PLP) was studied using a microtitre well binding assay and the ligand‐blot overlay technique. The binding of iodinated PLP to MBP that was immobilized on microtitre wells was saturable and reversible.
J. B. Ulmer +3 more
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The distribution of myelin basic protein mRNAs within myelinating oligodendrocytes
Trends in Neurosciences, 1993The nervous system contains oligodendrocytes with processes that are greatly extended in space. It is now clear that there are numerous complex, poorly understood mechanisms by which polypeptides are synthesized and delivered to their sites of function in these cells.
Peter J. Brophy +2 more
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Nuclear transport of myelin basic protein
Journal of Neuroscience Research, 1997The multiple myelin basic protein (MBP) isoforms expressed by myelinating cells are now known to have different expression patterns. The relative abundance of the isoforms containing exon II is greater early in myelinogenesis, whereas in compact myelin the isoforms lacking this exon are more abundant.
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Spontaneous vesicularization of myelin lipids is counteracted by myelin basic protein
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1986Hand-vortexed dispersions of several lipids (cerebrosides, sulfatides, PC, PE, PS and sphingomyelin), mixed in the ratios found for these categories of lipids in myelin, exhibit 31P-NMR spectra which have contributions from both isotropic and lamellar resonances.
Paul E. Fraser +3 more
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