Depletion of Microglia Increases Cortical Oligodendrocyte Density During Remyelination
Cuprizone demyelination induces transient reactive states in deep cortical microglia (MG) through early recovery. Depleting MG in recovery increases the number of deep cortical mature/pre‐myelinating oligodendrocytes. Deep cortical reactive MG reduce oligodendrocyte density after demyelination.
Hannah Katherine Loo +5 more
wiley +1 more source
Individual neuronal subtypes control initial myelin sheath growth and stabilization. [PDF]
Nelson HN +9 more
europepmc +1 more source
Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression
Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Carla Peiró‐Moreno +7 more
wiley +1 more source
Prospero-related homeobox protein 1 (Prox1) enhances myelin sheath regeneration in injured sciatic nerve. [PDF]
Jie L +6 more
europepmc +1 more source
CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity
CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Sophie Hümmert +14 more
wiley +1 more source
CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes
Marie E Bechler +2 more
semanticscholar +1 more source
Bee Venom Proteins Enhance Proton Absorption by Membranes Composed of Phospholipids of the Myelin Sheath and Endoplasmic Reticulum: Pharmacological Relevance. [PDF]
Zeng Z +5 more
europepmc +1 more source
Lactate Dehydrogenase Inhibition Reverts the Fatty Acid‐Induced Neurotoxic Phenotype of Astrocytes
ALS models display increased LD accumulation. LD accumulation is linked to a neurotoxic phenotype in astrocytes. Lactate dehydrogenase inhibition reverts LD accumulation in ALS astrocytes. ABSTRACT Astrocytes are central to lipid metabolism in the central nervous system.
Daniel Esteve +5 more
wiley +1 more source
Electroacupuncture alleviates sciatic nerve injury in sciatica rats by regulating BDNF and NGF levels, myelin sheath degradation, and autophagy. [PDF]
Liu Z, Zhang Q, Zhang X, He Q, Tian Y.
europepmc +1 more source

