Results 1 to 10 of about 15,205 (212)

MHC class I and II expression and induction in oligodendrocytes varies with age [PDF]

Scientific Reports
Oligodendroglia expressing major histocompatibility complex (MHC) molecules have become of central interest in multiple sclerosis (MS) research, but their role in aging is still being elucidated.
Riley B. Catenacci, Danny Galleguillos, Adriana Rhodes, Sloan Phillips, Peter A. Calabresi   +4 more
doaj   +2 more sources

Oligodendroglia: metabolic supporters of axons [PDF]

Trends in Cell Biology, 2013
Axons are specialized extensions of neurons that are critical for the organization of the nervous system. To maintain function in axons that often extend some distance from the cell body, specialized mechanisms of energy delivery are likely to be necessary.
Brett M Morrison, Youngjin Lee, Jeffrey D Rothstein   +2 more
exaly   +3 more sources

Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication [PDF]

Nature Communications
Emerging evidence links oligodendrocyte (OL) lineage cells and myelin to cognitive processes, yet the role of myelination in shaping neuronal networks critical for cognitive tasks remains unknown.
Fabrice Plaisier, Cristóbal Ibaceta-González, Hasni Khelfaoui, Adrianne E. S. Watson, Corinne Poilbout, Anastassia Voronova, María Cecilia Angulo   +6 more
doaj   +2 more sources

Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth [PDF]

iScience
Summary: Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in myelin physiology and function.
Mary-Amélie Masson, Mariana Graciarena, Marion Porte, Brahim Nait-Oumesmar   +3 more
doaj   +2 more sources

Paradoxes in the Ontological Classification of Glia—Evidence for an Important New Class of Brain Cells with Primary Functions in Iron Regulation [PDF]

Cells
The ontological categorization of the cellular elements of the brain was proposed over a century ago by Santiago Ramón y Cajal (neurons, astroglia) and Pío del Río-Hortega (oligodendroglia, microglia). It combines histochemical observations of morphology
Adrienne E. Milward, Rebecca J. Hood, Chan-An Lin, Conceição Bettencourt, Elvis Acquah, Jake Brooks, Joanna F. Collingwood, Yoshiteru Kagawa, Samantha J. Richardson, Yuting Wu, Yi Lu, Mirella Dottori, Daniel M. Johnstone   +12 more
doaj   +2 more sources

A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome [PDF]

Acta Neuropathologica Communications
Wolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene.
K. Ahuja, M. Vandenabeele, F. Nami, E. Lefevere, J. Van hoecke, S. Bergmans, M. Claes, T. Vervliet, K. Neyrinck, T. Burg, D. De Herdt, P. Bhaskar, Y. Zhu, Z. J. Looser, J. Loncke, W. Gsell, M. Plaas, P. Agostinis, J. V. Swinnen, L. Van Den Bosch, G. Bultynck, A. S. Saab, E. Wolfs, Y. C. Chai, U. Himmelreich, C. Verfaillie, L. Moons, L. De Groef   +27 more
doaj   +2 more sources

Beyond Myelination: Possible Roles of the Immune Proteasome in Oligodendroglial Homeostasis and Dysfunction

Frontiers in Neuroscience, 2022
Oligodendroglia play a critical role in CNS homeostasis by myelinating neuronal axons in their mature stages. Dysfunction in this lineage occurs when early stage OPCs are not able to differentiate to replace dying Mature Myelinating Oligodendrocytes ...
Miguel M. Madeira, Miguel M. Madeira, Miguel M. Madeira, Zachary Hage, Zachary Hage, Stella E. Tsirka, Stella E. Tsirka, Stella E. Tsirka   +7 more
doaj   +1 more source

Chromatin remodelers in oligodendroglia [PDF]

Glia, 2020
AbstractOligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and ...
Carlos Parras, Corentine Marie, Chuntao Zhao, Qing Richard Lu   +3 more
openaire   +3 more sources

Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation

Genome Biology, 2022
Background Circular RNAs (circRNAs), a novel class of poorly conserved non-coding RNAs that regulate gene expression, are highly enriched in the human brain.
Yangping Li, Feng Wang, Peng Teng, Li Ku, Li Chen, Yue Feng, Bing Yao   +6 more
doaj   +1 more source

Oligodendroglial Heterogeneity in Neuropsychiatric Disease

Life, 2021
Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and ...
Sunniva M. K. Bøstrand, Anna Williams
doaj   +1 more source