MHC class I and II expression and induction in oligodendrocytes varies with age [PDF]
Scientific ReportsOligodendroglia expressing major histocompatibility complex (MHC) molecules have become of central interest in multiple sclerosis (MS) research, but their role in aging is still being elucidated.
Riley B. Catenacci +4 more
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Spatial transcriptomics reveal heterogeneous cell‒cell interactions among brain regions in cuprizone model consistent with multiple sclerosis lesions [PDF]
Frontiers in BioinformaticsThe cuprizone (CPZ) model is widely used for modeling demyelination in multiple sclerosis (MS) and for testing potential remyelination therapies.
Hui-Hsin Tsai +29 more
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Oligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1 [PDF]
The Journal of Clinical InvestigationSpinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease marked by progressive motor deficits and Purkinje cell (PC) degeneration, driven by polyglutamine expansion in ataxin-1.
Changwoo Lee +9 more
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Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication [PDF]
Nature CommunicationsEmerging evidence links oligodendrocyte (OL) lineage cells and myelin to cognitive processes, yet the role of myelination in shaping neuronal networks critical for cognitive tasks remains unknown.
Fabrice Plaisier +6 more
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α-Synuclein overexpression increases the tropism of pre-formed fibrils and MSA-patient derived seeds towards oligodendroglia [PDF]
Acta Neuropathologica CommunicationsMultiple system atrophy (MSA) is a rare, fatal neurodegenerative disease, pathologically characterized by glial cytoplasmic inclusions (GCIs) containing α-synuclein (αSyn).
Anne-Line Strange Laursen +19 more
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Cell Reports, 2023 Summary: Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology.
Johan Jakobsson
exaly +3 more sources
Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth [PDF]
iScienceSummary: Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in myelin physiology and function.
Mary-Amélie Masson +3 more
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Paradoxes in the Ontological Classification of Glia—Evidence for an Important New Class of Brain Cells with Primary Functions in Iron Regulation [PDF]
CellsThe ontological categorization of the cellular elements of the brain was proposed over a century ago by Santiago Ramón y Cajal (neurons, astroglia) and Pío del Río-Hortega (oligodendroglia, microglia). It combines histochemical observations of morphology
Adrienne E. Milward +12 more
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Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia [PDF]
Nature CommunicationsDysconnectivity in schizophrenia is a pervasive concept across various levels of systems biology. To better understand disrupted patterns of molecular connectivity in schizophrenia, we apply innovative approaches to gene co-expression networks starting ...
Eugenia Radulescu +9 more
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Frontiers in Neuroscience, 2022 Oligodendroglia play a critical role in CNS homeostasis by myelinating neuronal axons in their mature stages. Dysfunction in this lineage occurs when early stage OPCs are not able to differentiate to replace dying Mature Myelinating Oligodendrocytes ...
Miguel M. Madeira +7 more
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