Results 31 to 40 of about 11,172 (159)

The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation

Frontiers in Cellular Neuroscience, 2023
Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to neurological dysfunction and, if myelin repair fails, neurodegeneration of the
Mohanlall Narine, Mohanlall Narine, Maryam A. Azmi, Martin Umali, Ashley Volz, Holly Colognato   +5 more
doaj   +1 more source

Sleep Disturbance in Bipolar Disorder: Neuroglia and Circadian Rhythms

Frontiers in Psychiatry, 2019
The worldwide prevalence of sleep disorders is approximately 50%, with an even higher occurrence in a psychiatric population. Bipolar disorder (BD) is a severe mental illness characterized by shifts in mood and activity.
Luca Steardo, Renato de Filippis, Elvira Anna Carbone, Cristina Segura-Garcia, Alexei Verkhratsky, Alexei Verkhratsky, Pasquale De Fazio   +6 more
doaj   +1 more source

Quetiapine Modulates Histone Methylation Status in Oligodendroglia and Rescues Adolescent Behavioral Alterations of Socially Isolated Mice

Frontiers in Psychiatry, 2020
Epigenetic alterations and impaired oligodendroglial myelination in the prefrontal cortex have been shown to correlate with behavioral and cognitive dysfunctions in social deprivation.
Xianjun Chen, Xianjun Chen, Hao Liu, Jingli Gan, Xiaorui Wang, Guangdan Yu, Tao Li, Xuejun Liang, Bin Yu, Lan Xiao, Lan Xiao   +10 more
doaj   +1 more source

Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins

Stem Cell Reports, 2019
Summary: The process of oligodendrogenesis has been relatively well delineated in the rodent brain. However, it remains unknown whether analogous developmental processes are manifested in the human brain.
Hyosung Kim, Ranjie Xu, Ragunathan Padmashri, Anna Dunaevsky, Ying Liu, Cheryl F. Dreyfus, Peng Jiang   +6 more
doaj   +1 more source

An Autopsy Case With Fragile X-Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System. [PDF]

Neuropathology
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Shioya A, Ishii K, Sato T, Noguchi M, Tamaoka A, Saito Y.   +5 more
europepmc   +2 more sources

LIGHT-SCATTERING PATTERNS OF ISOLATED OLIGODENDROGLIA

, 1974
A technique for determining the large angle light-scattering patterns of biologic cells has been developed and applied to the measurement of isolated calf oligodendroglia.
S. F. HAASE, G. M. MCKHANN, S. E. PODUSLO, R. A. MEYER   +3 more
core   +1 more source

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy [PDF]

, 2013
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh, Lubetzki Catherine, Kragh, Christine L, Manuela Neumann, Neumann, Manuela, Lubetzki, Catherine, Bernard Zalc, Glenda M Halliday, Jensen, Poul H, Gai, Wei-Ping, Wei-Ping Gai, Kragh, Christine, Zalc Bernard, Jensen, Poul, Christian Haass, Fillon, Gwenaëlle, Gysbers Amanda, Philipp J Kahle, Richter-Landsberg, Christiane, Fillon Gwenaëlle, Halliday, Glenda M., Hansen, Hanne D, Gwenaëlle Fillon, Gai, Wei Ping, Kragh, Christine L., Hansen, Hanne, Amanda Gysbers, Catherine Lubetzki, Smith, Wanli, Christiane Richter-Landsberg, Kahle Philipp J., Zalc, Bernard, Haass Christian, Richter-Landsberg, Christian, Halliday, Glenda,, Kahle, Philipp J., Kahle, Philipp, Gysbers, Amanda, Hansen, Hanne D., Jensen, Poul H., Richter-Landsberg Christiane, Halliday Glenda M., Kahle, Philipp J, Halliday, Glenda M, Kragh Christine L., Jensen Poul H., Neumann Manuela, Hansen Hanne D., Poul H Jensen, Haass, Christian, Hanne D Hansen, Gai Wei-Ping, Halliday, Glenda, M.   +52 more
core   +2 more sources

Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo [PDF]

, 2020
International audienceRemyelination failure in multiple sclerosis (MS) is associated with a migration/differentiation block of oligodendroglia. The reason for this block is highly debated.
Levy, Marion, J F, Manot Saillet, Blandine, Schöler, Hans,, Starost, Laura, Kuhlmann, Tanja, Antel, Jack P, Baron-van Evercooren, Anne, Levy, Marion J F, Levy, Marion,, Schöler, Hans R, Baron Van Evercooren, Anne, Angulo, Maria Cecilia, Kennedy, Timothy,, Garcia Diaz, Beatriz, Manot-Saillet, Blandine, Kim, Kee Pyo, martino, Ottoboni, Linda, Roussel, Delphine, Antel, Jack, P, Schöler, Hans, R, Kulmann, Tanja, Martino, Gianvito, Xu, Yu Kang T, Kennedy, Timothy E, Mozafari, Sabah, Kennedy, Timothy, E, T Xu, Yu Kang, Garcia-Diaz, Beatriz, Antel, Jack,, Kim, Kee-Pyo   +30 more
core   +1 more source

Melanocortins, Melanocortin Receptors and Multiple Sclerosis

Brain Sciences, 2017
The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis.
Robert P. Lisak, Joyce A. Benjamins
doaj   +1 more source

Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles

Cell Communication and Signaling, 2022
Background The contribution of native or modified oligodendroglia-derived extracellular vesicles (OL-EVs) in controlling chronic inflammation is poorly understood. In activated microglia, OL-EVs contribute to the removal of cytotoxic proteins following a
Bram Van den Broek, Charlotte Wuyts, Angela Sisto, Isabel Pintelon, Jean-Pierre Timmermans, Veerle Somers, Vincent Timmerman, Niels Hellings, Joy Irobi   +8 more
doaj   +1 more source