Results 41 to 50 of about 289 (129)

Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases

Frontiers in Neuroscience, 2021
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders, often considered as the extreme manifestations of a disease spectrum, as they share similar pathomechanisms.
Chiara F. Valori, Manuela Neumann, Manuela Neumann   +2 more
doaj   +1 more source

High incidence of Y‐chromosome mosaicism in male and female individuals with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy

Epilepsia, EarlyView.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an underrecognized pediatric cortical lesion associated with somatic X‐linked SLC35A2 variants in approximately 50% of individuals. The genetic etiology in individuals without detectable SLC35A2 mutations remains undefined, which limits
Erica Cecchini, Till Hartlieb, Ahmed Gaballa, Katja Kobow, Mitali Katoch, Paraskevi Chasani, Georgia Vasileiou, Wiebke Hofer, Lea M. Reisch, Manfred Kudernatsch, Christian G. Bien, Roland Coras, Ingmar Blümcke, Lucas Hoffmann   +13 more
wiley   +1 more source

The Absolute Number of Oligodendrocytes in the Adult Mouse Brain

Frontiers in Neuroanatomy, 2018
The central nervous system is a highly complex network composed of various cell types, each one with different subpopulations. Each cell type has distinct roles for the functional operation of circuits, and ultimately, for brain physiology in general ...
Bruna Valério-Gomes, Daniel M. Guimarães, Diego Szczupak, Roberto Lent, Roberto Lent   +4 more
doaj   +1 more source

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

eLife, 2020
Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express ...
Magali Macchi, Karine Magalon, Céline Zimmer, Elitsa Peeva, Bilal El Waly, Béatrice Brousse, Sarah Jaekel, Kay Grobe, Friedemann Kiefer, Anna Williams, Myriam Cayre, Pascale Durbec   +11 more
doaj   +1 more source

Perineuronal satellite neuroglia in the telencephalon of New Caledonian crows and other Passeriformes: evidence of satellite glial cells in the central nervous system of healthy birds? [PDF]

PeerJ, 2013
Glia have been implicated in a variety of functions in the central nervous system, including the control of the neuronal extracellular space, synaptic plasticity and transmission, development and adult neurogenesis.
Felipe S. Medina, Gavin R. Hunt, Russell D. Gray, J. Martin Wild, M. Fabiana Kubke   +4 more
doaj   +2 more sources

Oligodendroglia and neurotrophic factors in neurodegeneration

Neuroscience Bulletin, 2013
Myelination by oligodendroglial cells (OLs) enables the propagation of action potentials along neuronal axons, which is essential for rapid information flow in the central nervous system. Besides saltatory conduction, the myelin sheath also protects axons against inflammatory and oxidative insults. Loss of myelin results in axonal damage and ultimately
Andrew N, Bankston, Mariana D, Mandler, Yue, Feng   +2 more
openaire   +3 more sources

Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication

Nature Communications
Emerging evidence links oligodendrocyte (OL) lineage cells and myelin to cognitive processes, yet the role of myelination in shaping neuronal networks critical for cognitive tasks remains unknown.
Fabrice Plaisier, Cristóbal Ibaceta-González, Hasni Khelfaoui, Adrianne E. S. Watson, Corinne Poilbout, Anastassia Voronova, María Cecilia Angulo   +6 more
doaj   +1 more source

Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders

Brain Sciences, 2017
Alcoholism is a chronic relapsing disorder with few therapeutic strategies that address the core pathophysiology. Brain tissue loss and oxidative damage are key components of alcoholism, such that reversal of these phenomena may help break the addictive ...
Chitra D. Mandyam, Emmanuel G. Villalpando, Noah L. Steiner, Leon W. Quach, McKenzie J. Fannon, Sucharita S. Somkuwar   +5 more
doaj   +1 more source

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

eLife, 2023
Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined.
Em P Harrington, Riley B Catenacci, Matthew D Smith, Dongeun Heo, Cecilia E Miller, Keya R Meyers, Jenna Glatzer, Dwight E Bergles, Peter A Calabresi   +8 more
doaj   +1 more source

A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome

Acta Neuropathologica Communications
Wolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene.
K. Ahuja, M. Vandenabeele, F. Nami, E. Lefevere, J. Van hoecke, S. Bergmans, M. Claes, T. Vervliet, K. Neyrinck, T. Burg, D. De Herdt, P. Bhaskar, Y. Zhu, Z. J. Looser, J. Loncke, W. Gsell, M. Plaas, P. Agostinis, J. V. Swinnen, L. Van Den Bosch, G. Bultynck, A. S. Saab, E. Wolfs, Y. C. Chai, U. Himmelreich, C. Verfaillie, L. Moons, L. De Groef   +27 more
doaj   +1 more source