Results 41 to 50 of about 11,172 (159)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Oligodendroglia metabolically support axons and contribute to neurodegeneration

, 2012
Oligodendroglia support axon survival and function through mechanisms independent of myelination, and their dysfunction leads to axon degeneration in several diseases. The cause of this degeneration has not been determined, but lack of energy metabolites
Magistretti, P. J., Lee, Y., Farah, M. H., Paul N. Hoffman, Mohamed H. Farah, Yun Li, Li, Y., Magistretti, P.J., Hoffman, P. N., Sylvain Lengacher, Jeffrey D. Rothstein, Farah, M.H., Jin, L., Rothstein, J.D., Lengacher, S., Tsingalia, A., Zhang, P.W., Zhang, P. W., Ping-Wu Zhang, Brett M. Morrison, Lin Jin, Pierre J. Magistretti, Hoffman, P.N., Liu, Y., Morrison, B. M., Morrison, B.M., Akivaga Tsingalia, Yiting Liu, Pellerin, L., Luc Pellerin, Rothstein, J. D., Youngjin Lee   +31 more
core   +1 more source

NG2-Glia Cause Diabetic Blood-Brain Barrier Disruption by Secreting MMP-9 [PDF]

Diabetes & Metabolism Journal
Background Disorders of the blood-brain barrier (BBB) arising from diabetes mellitus are closely related to diabetic encephalopathy. Previous research has suggested that neuron-glia antigen 2 (NG2)-glia plays a key role in maintaining the integrity of ...
Xiaolong Li, Yan Cai, Zhu Zhong, Maolin Li, Dong Huang, Zhifei Qiao, Hongli Zhou, Zuo Zhang, Jiyin Zhou   +8 more
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention

, 1993
Periventricular white matter injury, the principal variety of brain injury of the human premature infant, involves differentiating oligodendroglia. Nothing is known of the biochemical mechanism of oligodendroglial death in this disorder. Because an early
A Oka, JJ Volpe, MJ Belliveau, PA Rosenberg   +3 more
core   +1 more source

Early proliferation does not prevent the loss of oligodendrocyte progenitor cells during the chronic phase of secondary degeneration in a CNS white matter tract. [PDF]

PLoS ONE, 2013
Partial injury to the central nervous system (CNS) is exacerbated by additional loss of neurons and glia via toxic events known as secondary degeneration.
Sophie C Payne, Carole A Bartlett, Donna L Savigni, Alan R Harvey, Sarah A Dunlop, Melinda Fitzgerald   +5 more
doaj   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, Volume 13, Issue 53, 24 September 2026.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Disrupted CXCR2 Signaling in Oligodendroglia Lineage Cells Enhances Myelin Repair in a Viral Model of Multiple Sclerosis. [PDF]

, 2019
CXCR2 is a chemokine receptor expressed on oligodendroglia that has been implicated in the pathogenesis of neuroinflammatory demyelinating diseases as well as enhancement of the migration, proliferation, and myelin production by oligodendroglia. Using an
Marro, Brett S, Grist, Jonathan, Liu, Liping, Dickey, Laura L, Stone, Colleen, Marro, Brett, Skinner, Dominic D, Ransohoff, Richard M, Lane, Thomas E, Eckman, Emily, Lane, Thomas, Grist, Jonathan J, Skinner, Dominic, Dickey, Laura, Ransohoff, Richard, Cheng, Yuting   +15 more
core   +1 more source

The Absolute Number of Oligodendrocytes in the Adult Mouse Brain

Frontiers in Neuroanatomy, 2018
The central nervous system is a highly complex network composed of various cell types, each one with different subpopulations. Each cell type has distinct roles for the functional operation of circuits, and ultimately, for brain physiology in general ...
Bruna Valério-Gomes, Daniel M. Guimarães, Diego Szczupak, Roberto Lent, Roberto Lent   +4 more
doaj   +1 more source