Results 51 to 60 of about 289 (129)
Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders
Frontiers in Molecular Neuroscience, 2018 Depressive disorders are complex, multifactorial mental disorders with unknown neurobiology. Numerous theories aim to explain the pathophysiology. According to the “gliocentric theory”, glial abnormalities are responsible for the development of the ...
Boldizsár Czéh +5 more
doaj +1 more source
eLife, 2022 The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs) to complex and extensive myelinating oligodendrocytes (OLs) is a multistep process that involves large-scale morphological changes with significant strain on the ...
Emeric Merour +15 more
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Brain Pathology, Volume 36, Issue 4, July 2026.Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong +8 more
wiley +1 more source
Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.Tumours historically termed extraventricular neurocytoma form a distinct epigenetic and molecular glioneuronal tumour class characterised by neurocytic differentiation and recurrent MAPK pathway alterations, predominantly involving FGFR1. The identification of these tumours in both intraventricular and extraventricular locations demonstrates that ...
Alice Métais +15 more
wiley +1 more source
The oligodendroglia cytoskeleton in health and disease [PDF]
Journal of Neuroscience Research, 2000 Oligodendrocytes have a high rate of synthetic activity and produce vast amounts of myelin. The membrane production requires specific sorting and transport processes and structural support. In culture, oligodendrocytes extend flat membranous sheets containing an extensive cytoskeletal network of microtubules (MTs) and microfilaments (MFs).
openaire +3 more sources
Redistribution and internalization of antibodies to galactocerebroside by oligodendroglia [PDF]
The Journal of Neuroscience, 1988 Glial cultures from mouse brain were used to examine the direct interaction between oligodendroglia and antibodies to galactocerebroside (GalC). The external surface of oligodendroglial membrane sheets showed large GalC+ patches separated by a GalC- network after exposure to anti-GalC and fluoresceinated second antibody at 37 degrees C.
C A, Dyer, J A, Benjamins
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Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION The COVID‐19 pandemic underscored the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection on worsening the severity of Alzheimer's disease (AD) neuropathology and disease progression. METHODS Aged 5xFAD and wild‐type (WT) mice were infected with a mouse‐adapted SARS‐CoV‐2 (MA10), and extensive ...
Susana Furman +14 more
wiley +1 more source
Uncovering the Role of Sox2 in Oligodendroglia [PDF]
The Journal of Neuroscience, 2018 In the CNS, oligodendrocytes are responsible for the formation of myelin. To build these insulating sheaths surrounding axons, cells of the oligodendrocyte lineage must go through an intricate and temporally matched sequence of proliferation, migration, differentiation, and myelination ...
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CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.In an organotypic cerebellar slice culture (OSC) ex vivo demyelination model, teriflunomide has been shown to positively affect myelin preservation during demyelination and enhance remyelination. This is hypothesized as being achieved by modulating the dynamics of glial cells.
Jessica Kronenberg +8 more
wiley +1 more source
European Journal of Neurology, Volume 33, Issue 4, April 2026.A novel semi‐automated 3D immunofluorescence technique enables full volumetric quantification of intraneural phospho‐α‐synuclein load in skin biopsies. It refines conventional visually based signal assessment through a more objective, computer‐assisted procedure and provides burden‐dependent test results important for differential diagnostics.
Sophia Lonczewski +9 more
wiley +1 more source