Results 51 to 60 of about 15,205 (212)

Early proliferation does not prevent the loss of oligodendrocyte progenitor cells during the chronic phase of secondary degeneration in a CNS white matter tract. [PDF]

PLoS ONE, 2013
Partial injury to the central nervous system (CNS) is exacerbated by additional loss of neurons and glia via toxic events known as secondary degeneration.
Sophie C Payne, Carole A Bartlett, Donna L Savigni, Alan R Harvey, Sarah A Dunlop, Melinda Fitzgerald   +5 more
doaj   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats [PDF]

, 2018
Dementia is a major social and economic problem for our aging population. One of the most common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic resonance scans of SVD patients typically show white matter abnormalities, but we
Atanur, Santosh S., Dominiczak, Anna F., Fornage, Myriam, Graham, Delyth, Harris, Sarah E., Quick, Sophie, Rajani, Rikesh M., Ruigrok, Silvie R., Seshadri, Sudha, Smith, Colin, Verhaaren, Benjamin F. J., Wardlaw, Joanna M., Williams, Anna   +12 more
core   +3 more sources

NG2-Glia Cause Diabetic Blood-Brain Barrier Disruption by Secreting MMP-9 [PDF]

Diabetes & Metabolism Journal
Background Disorders of the blood-brain barrier (BBB) arising from diabetes mellitus are closely related to diabetic encephalopathy. Previous research has suggested that neuron-glia antigen 2 (NG2)-glia plays a key role in maintaining the integrity of ...
Xiaolong Li, Yan Cai, Zhu Zhong, Maolin Li, Dong Huang, Zhifei Qiao, Hongli Zhou, Zuo Zhang, Jiyin Zhou   +8 more
doaj   +1 more source

Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases

Frontiers in Neuroscience, 2021
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders, often considered as the extreme manifestations of a disease spectrum, as they share similar pathomechanisms.
Chiara F. Valori, Manuela Neumann, Manuela Neumann   +2 more
doaj   +1 more source

Oligodendroglia and neurotrophic factors in neurodegeneration

Neuroscience Bulletin, 2013
Myelination by oligodendroglial cells (OLs) enables the propagation of action potentials along neuronal axons, which is essential for rapid information flow in the central nervous system. Besides saltatory conduction, the myelin sheath also protects axons against inflammatory and oxidative insults. Loss of myelin results in axonal damage and ultimately
Andrew N, Bankston, Mariana D, Mandler, Yue, Feng   +2 more
openaire   +3 more sources

Infection of 5xFAD mice with a mouse‐adapted SARS‐CoV‐2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The COVID‐19 pandemic underscored the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection on worsening the severity of Alzheimer's disease (AD) neuropathology and disease progression. METHODS Aged 5xFAD and wild‐type (WT) mice were infected with a mouse‐adapted SARS‐CoV‐2 (MA10), and extensive ...
Susana Furman, Latifa Zayou, Kate Inman Tsourmas, Dominic Ibarra Javonillo, Gema M. Olivarria, Yuting Cheng, Collin Pachow, Kellie Fernandez, Lucas Le, Robert A. Edwards, Dequina A. Nicholas, Gabriela Pacheco Sanchez, Ralph S. Baric, Kim N. Green, Thomas E. Lane   +14 more
wiley   +1 more source

The Absolute Number of Oligodendrocytes in the Adult Mouse Brain

Frontiers in Neuroanatomy, 2018
The central nervous system is a highly complex network composed of various cell types, each one with different subpopulations. Each cell type has distinct roles for the functional operation of circuits, and ultimately, for brain physiology in general ...
Bruna Valério-Gomes, Daniel M. Guimarães, Diego Szczupak, Roberto Lent, Roberto Lent   +4 more
doaj   +1 more source

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

eLife, 2020
Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express ...
Magali Macchi, Karine Magalon, Céline Zimmer, Elitsa Peeva, Bilal El Waly, Béatrice Brousse, Sarah Jaekel, Kay Grobe, Friedemann Kiefer, Anna Williams, Myriam Cayre, Pascale Durbec   +11 more
doaj   +1 more source

Perineuronal satellite neuroglia in the telencephalon of New Caledonian crows and other Passeriformes: evidence of satellite glial cells in the central nervous system of healthy birds? [PDF]

PeerJ, 2013
Glia have been implicated in a variety of functions in the central nervous system, including the control of the neuronal extracellular space, synaptic plasticity and transmission, development and adult neurogenesis.
Felipe S. Medina, Gavin R. Hunt, Russell D. Gray, J. Martin Wild, M. Fabiana Kubke   +4 more
doaj   +2 more sources