Results 71 to 80 of about 289 (129)
Journal of Neurochemistry, Volume 170, Issue 3, March 2026.The study investigates the functional consequences of INTS11 loss‐of‐function (LoF), a genetic alteration linked to neurodevelopmental disorder (NDD), using zebrafish as an in vivo model. To model ints11 deficiency, two complementary approaches are applied: morpholino‐mediated knock‐down and CRISPR–Cas9 transient knock‐out, establishing ints11‐LoF ...
Anna Pistocchi +9 more
wiley +1 more source
Glia, Volume 74, Issue 2, February 2026.Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips +9 more
wiley +1 more source
Mosaic subventricular origins of forebrain oligodendroglia
Frontiers in Neuroscience, 2016 In the perinatal as well as the adult CNS, the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates neurons and oligodendrocytes (OLs), the myelin forming cells of the CNS.
Kasum eAzim +2 more
doaj +1 more source
Extraneural Metastasis in Oligodendroglioma: A Comprehensive Review and Outcome Analysis of 90 Cases
Cancer Science, Volume 117, Issue 2, Page 316-324, February 2026.Oligodendroglioma liver metastasis. ABSTRACT Extraneural metastasis in oligodendroglioma is a rare and poorly characterized event. We report a case whereby liver and bone metastasis occurred 19 years after diagnosis. Next generation sequencing on brain and liver oligodendroglioma showed several common mutations and a few unique ones to each organ.
Ahmad Daher +4 more
wiley +1 more source
Neuropathology, Volume 46, Issue 1, February 2026.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón +3 more
wiley +1 more source
Back Again to the Future: A New Era for Cerebroprotection
Annals of Neurology, Volume 99, Issue 1, Page 19-34, January 2026.Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley +1 more source
Degeneração mucóide da oligodendroglia em um caso de enfermidade do grupo Wilson
Arquivos de Neuro-Psiquiatria, 1944 Recordam-se, no presente trabalho, as alterações da oligodendroglia em particular a degeneração mucóide. Relata-se sinteticamente um caso do grupo Wilson - espasmo de torção - em que havia degeneração mucóide da oligodendroglia predominantemente na ...
A. Austregésilo Filho
doaj
Acta Neuropathologica Communications, 2017 Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather ...
Ronald J. Mandel +7 more
doaj +1 more source
Editorial: Non-neuronal cell heterogeneity in the nervous system during health and disease
Frontiers in Cellular Neuroscience, 2022 Greg J. Duncan +6 more
doaj +1 more source