Acta Neuropathologica Communications, 2017 Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather ...
Ronald J. Mandel +7 more
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Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells [PDF]
, 2012 The adaptive immune response to viral vectors reduces vector-mediated transgene expression from the brain. It is unknown, however, whether this loss is caused by functional downregulation of transgene expression or death of transduced cells.
Ahmed +60 more
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Aerospace medicine and biology: A continuing bibliography with indexes (supplement 352) [PDF]
This bibliography lists 147 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during July 1991.
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The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination [PDF]
, 2016 Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The protective effects of melatonin (MLT) on various neurodegenerative diseases, including MS, have been suggested.
Ghadiri, T. +6 more
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Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination. [PDF]
, 2015 Lactate, a product of glycolysis, has been shown to play a key role in the metabolic support of neurons/axons in the CNS by both astrocytes and oligodendrocytes through monocarboxylate transporters (MCTs).
Baloui, H. +7 more
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Neurobiology of Disease, 2006 A novel population of hippocampal precursor cells (HPCs) that can be induced to differentiate into astrocytes and oligodendrocytes can be derived from hippocampal cultures grown in serum-free media.
Henry C. Tseng +5 more
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Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex. [PDF]
, 2018 Numerous types of inhibitory neurons sculpt the performance of human neocortical circuits, with each type exhibiting a constellation of subcellular phenotypic features in support of its specialized functions.
Chang, Edward F +9 more
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Herstellung und Charakterisierung von menschlichen Oligodendrozyten-Vorläuferzellinien [PDF]
, 2006 Bei der Multiplen Sklerose kommen im Verlauf der Erkrankung das Myelin und die Oligodendrozyten zu Schaden. Zu Beginn der Erkrankung kann man Remyelinisierungsvorgänge beobachten.
Onischke, Claus, Sommer, N. (Prof)
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FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. [PDF]
, 2014 BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration for treatment of patients with the relapsing-remitting form of the human demyelinating disease multiple sclerosis.
Blanc, Caroline A +2 more
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Oligodendroglia Are Particularly Vulnerable to Oxidative Damage After Neurotrauma In Vivo
Journal of Experimental Neuroscience, 2018 In the paper “Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo,” we determined the extent of oxidative damage to specific cellular subpopulations and structures within regions vulnerable to secondary degeneration ...
Marcus Giacci, Melinda Fitzgerald
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