Heterogeneity of mature oligodendrocytes in the central nervous system
Neural Regeneration ResearchMature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.
Chao Weng +6 more
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Aging Cell, Volume 25, Issue 1, January 2026.Our single nuclei RNA sequencing data reveal that long‐term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restriction attenuates an immune signature and promotes axonal proximity, while reducing a myelin‐laden microglia population.
Ana T. Vitantonio +13 more
wiley +1 more source
Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. [PDF]
, 2019 Disruption of the blood-brain barrier (BBB) is critical to initiation and perpetuation of disease in multiple sclerosis (MS). We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal ...
Baranzini, Sergio E +9 more
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Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment. [PDF]
, 2018 Increasing evidence points to an important role for neutrophils in participating in the pathogenesis of the human demyelinating disease MS and the animal model EAE.
Doty, Daniel J +7 more
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Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.Microglial EVs deliver C1q to pre‐synapses and promote synaptic pruning in vitro. C9orf72 KO microglia release more C1q‐storing EVs compared to WT and engulf more synapses in the hippocampus during the pruning period. Production of C1q‐storing EVs from WT microglia temporally correlates with the pruning period during postnatal development. ABSTRACT C1q
Giulia D'Arrigo +18 more
wiley +1 more source
Degeneração mucóide da oligodendroglia em um caso de enfermidade do grupo Wilson
Arquivos de Neuro-Psiquiatria, 1944 Recordam-se, no presente trabalho, as alterações da oligodendroglia em particular a degeneração mucóide. Relata-se sinteticamente um caso do grupo Wilson - espasmo de torção - em que havia degeneração mucóide da oligodendroglia predominantemente na ...
A. Austregésilo Filho
doaj
Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells [PDF]
, 2004 Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. NSCs can be directly isolated from fetal or adult nervous tissue,
Boehm, Bernhard O. +10 more
core
Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis. [PDF]
, 2012 Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Rivera, Francisco J
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Oligodendroglia: new players in amyotrophic lateral sclerosis [PDF]
Brain, 2013 The contribution of glial cells to the neuropathology and phenotype of amyotrophic lateral sclerosis (ALS) has become a focus for basic and translational research. Whereas astrocytes and microglia are studied in great detail, the contribution of oligodendrocytes has been relatively neglected.
openaire +2 more sources
Editorial: Non-neuronal cell heterogeneity in the nervous system during health and disease
Frontiers in Cellular Neuroscience, 2022 Greg J. Duncan +6 more
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