Results 61 to 70 of about 289 (129)

In vivo Optogenetic Approach to Study Neuron-Oligodendroglia Interactions in Mouse Pups

Frontiers in Cellular Neuroscience, 2018
Optogenetic and pharmacogenetic techniques have been effective to analyze the role of neuronal activity in controlling oligodendroglia lineage cells in behaving juvenile and adult mice. This kind of studies is also of high interest during early postnatal
Domiziana Ortolani, Domiziana Ortolani, Blandine Manot-Saillet, Blandine Manot-Saillet, David Orduz, Fernando C. Ortiz, Fernando C. Ortiz, Maria Cecilia Angulo, Maria Cecilia Angulo   +8 more
doaj   +1 more source

An Autopsy Case With Fragile X‐Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System

Neuropathology, Volume 46, Issue 2, April 2026.
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Ayako Shioya, Kazuhiro Ishii, Taiki Sato, Masayuki Noguchi, Akira Tamaoka, Yuko Saito   +5 more
wiley   +1 more source

Topographical Variation of Iron‐Rimmed Lesions in the Multiple Sclerosis Brain and Spinal Cord: A Neuropathological Study

Annals of Neurology, Volume 99, Issue 3, Page 730-736, March 2026.
Paramagnetic‐rim lesions are a novel diagnostic marker in multiple sclerosis (MS) and are associated with poor prognosis due to their link with chronic inflammation and disease progression. Analyzing 46 postmortem MS cases, researchers found no iron rims in 67 white matter and 85 grey matter spinal cord lesions, despite most being active.
Marco Pisa, Andrew Lockhart, Thomas Angell, Aimee Avery, Zaenab Dhari, Mary Bailey, Simon Hametner, Hal Drakesmith, Monika Hofer, Clara Limbaeck, Gabriele C DeLuca   +10 more
wiley   +1 more source

Adenosine Actions on Oligodendroglia and Myelination in Autism Spectrum Disorder

Frontiers in Cellular Neuroscience, 2018
Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental disorder. Independent of neuronal dysfunction, ASD and its associated comorbidities have been linked to hypomyelination and oligodendroglial dysfunction.
Hai-Ying Shen, Hai-Ying Shen, Nanxin Huang, Jesica Reemmer, Lan Xiao   +4 more
doaj   +1 more source

Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression

Glia, Volume 74, Issue 3, March 2026.
Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Carla Peiró‐Moreno, Juan Carlos Chara, Katy Marshall‐Phelps, Irune Ugarte‐Arakistain, Stefano Calovi, Rafael Gois De Almeida, María Domercq, Carlos Matute   +7 more
wiley   +1 more source

Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Borna disease virus is a neurotropic, non-cytolytic virus that has been widely employed in neuroscientific research. Previous studies have revealed that metabolic perturbations are associated with Borna disease viral infection.
Rongzhong Huang, Hongchang Gao, Liang Zhang, Jianmin Jia, Xia Liu, Peng Zheng, Lihua Ma, Wenjuan Li, Jing Deng, Xiao Wang, Liu Yang, Mingju Wang, Peng Xie   +12 more
doaj   +1 more source

Novel approaches for neuroprotection: Focus on neurodegenerative and ischemic central nervous system diseases

Neuroprotection, EarlyView.
Shen Li, Xunming Ji, Piotr Walczak, Johannes Boltze   +3 more
wiley   +1 more source

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
This study shows that the blood‐derived molecule, Fibrinogen, has a differential effect on human Oligodendroglial (OL) cells. Fibrinogen, when added in vitro, leads to aberrant differentiation of OL‐precursors towards an astrocytic fate. On the other hand, when added into the culture of mature OLs, fibrinogen increases myelination capacity.
Gabriela J. Blaszczyk, Chao Weng, Abdulshakour Mohammadnia, Qiao‐Ling Cui, Arianna Giurleo, Adam M. R. Groh, Chloe Plouffe, Julien Sirois, Valerio E. C. Piscopo, Moein Yaqubi, Asad Taqvi, Erin Cassidy, Liam Callahan Martin, Jeffery A. Hall, Roy W. R. Dudley, Myriam Srour, Stephanie E. J. Zandee, Wendy Klement, Sandra Larouche, Alexandre Prat, Thomas M. Durcan, Jo Anne Stratton, Jack P. Antel, G. R. Wayne Moore   +23 more
wiley   +1 more source

Heterogeneity of mature oligodendrocytes in the central nervous system

Neural Regeneration Research
Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.
Chao Weng, Adam M.R. Groh, Moein Yaqubi, Qiao-Ling Cui, Jo Anne Stratton, G. R. Wayne Moore, Jack P. Antel   +6 more
doaj   +1 more source

SIRT2, tubulin deacetylation, and oligodendroglia differentiation [PDF]

Cell Motility, 2007
AbstractThe mammalian silent information regulator 2 (SIRT2) is an NAD‐dependent histone deacetylase with known roles in the regulation of the cell cycle. SIRT2 is also a tubulin deacetylase functioning as an early mitotic checkpoint, but its roles in regulating cytoplasmic microtubule dynamics were unknown.
Bor Luen, Tang, Christelle En Lin, Chua
openaire   +2 more sources