Results 61 to 70 of about 11,172 (159)

Death of oligodendroglia subpopulations following partial ON transection.

, 2013
Dying oligodendroglia and other olig2+ glia were identified with antibodies to NG2 (A), olig2 (B) and TUNEL (C), or with CC1 (E) and TUNEL (F). D: Cells indicated are TUNEL+/NG2+/olig2+ cells (>). G: The cell indicated is TUNEL+/CC1+ (>).
Sarah A. Dunlop (292448), Sophie C. Payne (420253), Carole A. Bartlett (420254), Donna L. Savigni (420255), Melinda Fitzgerald (420256), Alan R. Harvey (333457)   +5 more
core   +1 more source

Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases

Frontiers in Neuroscience, 2021
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders, often considered as the extreme manifestations of a disease spectrum, as they share similar pathomechanisms.
Chiara F. Valori, Manuela Neumann, Manuela Neumann   +2 more
doaj   +1 more source

High incidence of Y‐chromosome mosaicism in male and female individuals with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy

Epilepsia, Volume 67, Issue 9, Page 4907-4921, September 2026.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an underrecognized pediatric cortical lesion associated with somatic X‐linked SLC35A2 variants in approximately 50% of individuals. The genetic etiology in individuals without detectable SLC35A2 mutations remains undefined, which limits
Erica Cecchini, Till Hartlieb, Ahmed Gaballa, Katja Kobow, Mitali Katoch, Paraskevi Chasani, Georgia Vasileiou, Wiebke Hofer, Lea M. Reisch, Manfred Kudernatsch, Christian G. Bien, Roland Coras, Ingmar Blümcke, Lucas Hoffmann   +13 more
wiley   +1 more source

Perineuronal satellite neuroglia in the telencephalon of New Caledonian crows and other Passeriformes: evidence of satellite glial cells in the central nervous system of healthy birds? [PDF]

PeerJ, 2013
Glia have been implicated in a variety of functions in the central nervous system, including the control of the neuronal extracellular space, synaptic plasticity and transmission, development and adult neurogenesis.
Felipe S. Medina, Gavin R. Hunt, Russell D. Gray, J. Martin Wild, M. Fabiana Kubke   +4 more
doaj   +2 more sources

Targeting progressive multiple sclerosis: Toward mechanism‐informed precision medicine

Journal of Internal Medicine, Volume 300, Issue 3, Page 238-257, September 2026.
Abstract Multiple sclerosis has undergone a therapeutic revolution over the past three decades. Randomized clinical trials and real‐world data demonstrate that modern disease‐modifying therapies substantially reduce relapse rates and acute inflammatory activity detected by magnetic resonance imaging (MRI).
Fredrik Piehl, Gonçalo Castelo‐Branco, Maja Jagodic, Tomas Olsson   +3 more
wiley   +1 more source

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

eLife, 2023
Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined.
Em P Harrington, Riley B Catenacci, Matthew D Smith, Dongeun Heo, Cecilia E Miller, Keya R Meyers, Jenna Glatzer, Dwight E Bergles, Peter A Calabresi   +8 more
doaj   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, Volume 36, Issue 4, July 2026.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Amyotrophic lateral sclerosis (ALS) involves widespread cortical pathology beyond the motor cortex. Human‐induced pluripotent stem cell‐derived neural organoids model cortical tissue in vitro and provide a physiologically relevant platform to study disease mechanisms in ALS.
Kristel N. Eigenhuis, Roberto Montoro Ferrer, R. Jeroen Pasterkamp   +2 more
wiley   +1 more source

Deciphering Freezing of Gait: What Neuropathology Reveals About an Episodic Phenomenon

European Journal of Neuroscience, Volume 63, Issue 12, June 2026.
Freezing of gait (FoG) occurs across Parkinson's disease, multiple neurodegenerative conditions and non‐neurodegenerative disorders. This review synthesizes the structural, neurochemical and proteinopathic substrates underlying FoG, showing how cumulative damage to distributed locomotor circuits—compounded by overlapping pathologies—progressively ...
Gabor G. Kovacs
wiley   +1 more source

Oligodendroglia and Myelin:Supporting the Connectome

Oligodendroglia are the only cell lineage of the central nervous system (CNS) responsible for producing myelin. They originate from precursor cells known as oligodendrocyte precursor cells (OPCs), which are born around the ventricular zones of the brain ...
Niu, Jianqin, Butt, Arthur, Verkhratsky, Alexei; id_orcid, Yi, Chenju   +3 more
core   +1 more source