Results 61 to 70 of about 15,205 (212)
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.In an organotypic cerebellar slice culture (OSC) ex vivo demyelination model, teriflunomide has been shown to positively affect myelin preservation during demyelination and enhance remyelination. This is hypothesized as being achieved by modulating the dynamics of glial cells.
Jessica Kronenberg +8 more
wiley +1 more source
Brain Sciences, 2017 Alcoholism is a chronic relapsing disorder with few therapeutic strategies that address the core pathophysiology. Brain tissue loss and oxidative damage are key components of alcoholism, such that reversal of these phenomena may help break the addictive ...
Chitra D. Mandyam +5 more
doaj +1 more source
eLife, 2023 Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined.
Em P Harrington +8 more
doaj +1 more source
European Journal of Neurology, Volume 33, Issue 4, April 2026.A novel semi‐automated 3D immunofluorescence technique enables full volumetric quantification of intraneural phospho‐α‐synuclein load in skin biopsies. It refines conventional visually based signal assessment through a more objective, computer‐assisted procedure and provides burden‐dependent test results important for differential diagnostics.
Sophia Lonczewski +9 more
wiley +1 more source
Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders
Frontiers in Molecular Neuroscience, 2018 Depressive disorders are complex, multifactorial mental disorders with unknown neurobiology. Numerous theories aim to explain the pathophysiology. According to the “gliocentric theory”, glial abnormalities are responsible for the development of the ...
Boldizsár Czéh +5 more
doaj +1 more source
eLife, 2022 The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs) to complex and extensive myelinating oligodendrocytes (OLs) is a multistep process that involves large-scale morphological changes with significant strain on the ...
Emeric Merour +15 more
doaj +1 more source
Annals of Neurology, Volume 99, Issue 3, Page 730-736, March 2026.Paramagnetic‐rim lesions are a novel diagnostic marker in multiple sclerosis (MS) and are associated with poor prognosis due to their link with chronic inflammation and disease progression. Analyzing 46 postmortem MS cases, researchers found no iron rims in 67 white matter and 85 grey matter spinal cord lesions, despite most being active.
Marco Pisa +10 more
wiley +1 more source
Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]
, 2007 Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland +16 more
core +2 more sources
Glia, Volume 74, Issue 2, February 2026.Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips +9 more
wiley +1 more source
Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1α [PDF]
, 2017 The premature increase of oxygen tension may contribute to oligodendroglial precursor cell (OPC) damage in preterm infants. Fetal OPCs are exposed to low oxygen tissue tensions not matched when cells are cultured in room air.
Brill, Christina +4 more
core +2 more sources