Results 21 to 30 of about 289 (129)

Autophagy in α-Synucleinopathies—An Overstrained System

open access: yesCells, 2021
Alpha-synucleinopathies comprise progressive neurodegenerative diseases, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).
Lisa Fellner   +3 more
doaj   +1 more source

Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers

open access: yesCells, 2021
During embryonic development, progenitor cells are progressively restricted in their potential to generate different neural cells. A specific progenitor cell type, the radial glial cells, divides symmetrically and then asymmetrically to produce neurons ...
Ana Cristina Ojalvo-Sanz   +1 more
doaj   +1 more source

Glioneuronal apoptosis and neuroinflammation in drug resistant temporal lobe epilepsy

open access: yesНеврология, нейропсихиатрия, психосоматика, 2023
The study of glioneuronal apoptosis and neuroinflammation is extremely important for understanding the causes of epilepsy. Currently, the focus is on neuronal apoptosis and certain aspects of neuroinflammation, while glial apoptosis remains poorly ...
T. V. Sokolova   +9 more
doaj   +1 more source

Ultrastructural study of the effects of cyclosporine in the brainstem of Wistar rats submitted to the ethidium bromide demyelinating model Estudo ultra-estrutural dos efeitos da ciclosporina no tronco encefálico de ratos Wistar submetidos ao modelo desmielinizante do brometo de etídio

open access: yesArquivos de Neuro-Psiquiatria, 2008
The ethidium bromide-demyelinating model (EB) was used to study remyelination in the brainstem under the use of cyclosporine (CsA). Wistar rats were submitted to intracisternal injection of 0.1% EB or 0.9% saline solution, and others were taken as ...
Eduardo Fernandes Bondan   +2 more
doaj   +1 more source

The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation

open access: yesFrontiers in Cellular Neuroscience, 2023
Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to neurological dysfunction and, if myelin repair fails, neurodegeneration of the
Mohanlall Narine   +5 more
doaj   +1 more source

Pathology of oligodendroglia: An overview [PDF]

open access: yesNeuropathology, 2017
Oligodendroglia are cells responsible for creating myelin sheaths for axons in the CNS. However, pathologies of oligodendroglia other than demyelination are not well understood due to the lack of adequate methods of characterizing pathological conditions affecting oligodendroglia in human tissue. This review discusses three major topics with the aim of
openaire   +2 more sources

Sleep Disturbance in Bipolar Disorder: Neuroglia and Circadian Rhythms

open access: yesFrontiers in Psychiatry, 2019
The worldwide prevalence of sleep disorders is approximately 50%, with an even higher occurrence in a psychiatric population. Bipolar disorder (BD) is a severe mental illness characterized by shifts in mood and activity.
Luca Steardo   +6 more
doaj   +1 more source

Quetiapine Modulates Histone Methylation Status in Oligodendroglia and Rescues Adolescent Behavioral Alterations of Socially Isolated Mice

open access: yesFrontiers in Psychiatry, 2020
Epigenetic alterations and impaired oligodendroglial myelination in the prefrontal cortex have been shown to correlate with behavioral and cognitive dysfunctions in social deprivation.
Xianjun Chen   +10 more
doaj   +1 more source

Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins

open access: yesStem Cell Reports, 2019
Summary: The process of oligodendrogenesis has been relatively well delineated in the rodent brain. However, it remains unknown whether analogous developmental processes are manifested in the human brain.
Hyosung Kim   +6 more
doaj   +1 more source

Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia

open access: yesCell Reports, 2023
Summary: Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology.
Raquel Garza   +14 more
doaj   +1 more source

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