Autophagy in α-Synucleinopathies—An Overstrained System
Cells, 2021 Alpha-synucleinopathies comprise progressive neurodegenerative diseases, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).
Lisa Fellner +3 more
doaj +1 more source
Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers
Cells, 2021 During embryonic development, progenitor cells are progressively restricted in their potential to generate different neural cells. A specific progenitor cell type, the radial glial cells, divides symmetrically and then asymmetrically to produce neurons ...
Ana Cristina Ojalvo-Sanz +1 more
doaj +1 more source
Glioneuronal apoptosis and neuroinflammation in drug resistant temporal lobe epilepsy
Неврология, нейропсихиатрия, психосоматика, 2023 The study of glioneuronal apoptosis and neuroinflammation is extremely important for understanding the causes of epilepsy. Currently, the focus is on neuronal apoptosis and certain aspects of neuroinflammation, while glial apoptosis remains poorly ...
T. V. Sokolova +9 more
doaj +1 more source
The next generation of spatial transcriptomics and AI to understand complex interactions between glial cells [PDF]
Alzheimers DementAbstract Emerging research highlights the significant contributions of non‐neuronal cells—astrocytes, microglia, and oligodendrocytes—in Alzheimer's disease (AD). These glial cells are not only implicated in neuroinflammation, synaptic dysfunction, and neurodegeneration but also engage in highly dynamic crosstalk that modulates key pathological ...
Das S.
europepmc +2 more sources
Identification of candidate causal risk genes and pathways in Alzheimer's disease and Lewy body dementia [PDF]
Alzheimers DementAbstract Background The neurodegenerative disorders Alzheimer's disease (AD) and Lewy body dementia (LBD) share genetic and clinicopathological overlap and may constitute a disease spectrum. Common variant genome‐wide association studies (GWASs) have uncovered AD and LBD etiology.
Picarello D +12 more
europepmc +2 more sources
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. [PDF]
, 2013 Oligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes downregulate transporters that transfer glycolytic substrates to neurons ...
Bergles, Dwight E +7 more
core +2 more sources
Oligodendroglia: metabolic supporters of neurons [PDF]
Journal of Clinical Investigation, 2017 Oligodendrocytes are glial cells that populate the entire CNS after they have differentiated from oligodendrocyte progenitor cells. From birth onward, oligodendrocytes initiate wrapping of neuronal axons with a multilamellar lipid structure called myelin.
Thomas, Philips, Jeffrey D, Rothstein
openaire +2 more sources
Disrupted CXCR2 Signaling in Oligodendroglia Lineage Cells Enhances Myelin Repair in a Viral Model of Multiple Sclerosis. [PDF]
, 2019 CXCR2 is a chemokine receptor expressed on oligodendroglia that has been implicated in the pathogenesis of neuroinflammatory demyelinating diseases as well as enhancement of the migration, proliferation, and myelin production by oligodendroglia. Using an
Cheng, Yuting +9 more
core +1 more source
Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. [PDF]
, 2019 Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and regenerative capabilities through the secretion of bioactive factors, such as proteins, cytokines, chemokines as well as the release of extracellular vesicles (EVs).
Barthe, Sylvain +11 more
core +2 more sources
MicroRNA-23a promotes myelination in the central nervous system. [PDF]
, 2013 Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui +5 more
core +2 more sources