Results 11 to 20 of about 11,172 (159)

Genetic and Epigenetic Alterations Underlie Oligodendroglia Susceptibility and White Matter Etiology in Psychiatric Disorders [PDF]

open access: yesFrontiers in Genetics, 2018
Numerous genetic risk loci are found to associate with major neuropsychiatric disorders represented by schizophrenia. The pathogenic roles of genetic risk loci in psychiatric diseases are further complicated by the association with cell lineage- and/or ...
Xianjun Chen   +3 more
doaj   +2 more sources

Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

open access: yesBMC Neuroscience, 2018
Background The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs).
Lisa Fellner   +5 more
doaj   +2 more sources

In vivo Optogenetic Approach to Study Neuron-Oligodendroglia Interactions in Mouse Pups [PDF]

open access: yesFrontiers in Cellular Neuroscience, 2018
Optogenetic and pharmacogenetic techniques have been effective to analyze the role of neuronal activity in controlling oligodendroglia lineage cells in behaving juvenile and adult mice. This kind of studies is also of high interest during early postnatal
Domiziana Ortolani   +8 more
doaj   +3 more sources

Adenosine Actions on Oligodendroglia and Myelination in Autism Spectrum Disorder [PDF]

open access: yesFrontiers in Cellular Neuroscience, 2018
Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental disorder. Independent of neuronal dysfunction, ASD and its associated comorbidities have been linked to hypomyelination and oligodendroglial dysfunction.
Hai-Ying Shen   +4 more
doaj   +2 more sources

Degeneração mucóide da oligodendroglia em um caso de enfermidade do grupo Wilson

open access: yesArquivos de Neuro-Psiquiatria, 1944
Recordam-se, no presente trabalho, as alterações da oligodendroglia em particular a degeneração mucóide. Relata-se sinteticamente um caso do grupo Wilson - espasmo de torção - em que havia degeneração mucóide da oligodendroglia predominantemente na ...
A. Austregésilo Filho
doaj   +1 more source

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease. [PDF]

open access: yesAlzheimers Dement
This study investigates ancestry-specific changes in induced pluripotent stem cell (iPSC)-derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the ...
Ramirez AM   +26 more
europepmc   +2 more sources

In vitro heterogeneity of human oligodendroglia [PDF]

open access: yes, 2023
Oligodendrocytes in the central nervous system (CNS) wrap their plasma membrane extensions around large calibre neuronal axons formulating the multi-layered myelin sheath.
Kazakou, Nina-Lydia
core   +1 more source

Oligodendroglia Are Particularly Vulnerable to Oxidative Damage After Neurotrauma In Vivo

open access: yesJournal of Experimental Neuroscience, 2018
In the paper “Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo,” we determined the extent of oxidative damage to specific cellular subpopulations and structures within regions vulnerable to secondary degeneration ...
Marcus Giacci, Melinda Fitzgerald
doaj   +2 more sources

Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation

open access: yesGenome Biology, 2022
Background Circular RNAs (circRNAs), a novel class of poorly conserved non-coding RNAs that regulate gene expression, are highly enriched in the human brain.
Yangping Li   +6 more
doaj   +1 more source

Oligodendroglial Heterogeneity in Neuropsychiatric Disease

open access: yesLife, 2021
Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and ...
Sunniva M. K. Bøstrand, Anna Williams
doaj   +1 more source

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