Results 11 to 20 of about 289 (129)

Oligodendroglia: metabolic supporters of axons [PDF]

Trends in Cell Biology, 2013
Axons are specialized extensions of neurons that are critical for the organization of the nervous system. To maintain function in axons that often extend some distance from the cell body, specialized mechanisms of energy delivery are likely to be necessary.
Brett M Morrison, Youngjin Lee, Jeffrey D Rothstein   +2 more
exaly   +3 more sources

Genetic and Epigenetic Alterations Underlie Oligodendroglia Susceptibility and White Matter Etiology in Psychiatric Disorders

Frontiers in Genetics, 2018
Numerous genetic risk loci are found to associate with major neuropsychiatric disorders represented by schizophrenia. The pathogenic roles of genetic risk loci in psychiatric diseases are further complicated by the association with cell lineage- and/or ...
Xianjun Chen, Lan Xiao, Chen Xianjun
exaly   +3 more sources

Beyond Myelination: Possible Roles of the Immune Proteasome in Oligodendroglial Homeostasis and Dysfunction

Frontiers in Neuroscience, 2022
Oligodendroglia play a critical role in CNS homeostasis by myelinating neuronal axons in their mature stages. Dysfunction in this lineage occurs when early stage OPCs are not able to differentiate to replace dying Mature Myelinating Oligodendrocytes ...
Miguel M. Madeira, Miguel M. Madeira, Miguel M. Madeira, Zachary Hage, Zachary Hage, Stella E. Tsirka, Stella E. Tsirka, Stella E. Tsirka   +7 more
doaj   +1 more source

Chromatin remodelers in oligodendroglia [PDF]

Glia, 2020
AbstractOligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and ...
Carlos Parras, Corentine Marie, Chuntao Zhao, Qing Richard Lu   +3 more
openaire   +3 more sources

Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation

Genome Biology, 2022
Background Circular RNAs (circRNAs), a novel class of poorly conserved non-coding RNAs that regulate gene expression, are highly enriched in the human brain.
Yangping Li, Feng Wang, Peng Teng, Li Ku, Li Chen, Yue Feng, Bing Yao   +6 more
doaj   +1 more source

Oligodendroglial Heterogeneity in Neuropsychiatric Disease

Life, 2021
Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and ...
Sunniva M. K. Bøstrand, Anna Williams
doaj   +1 more source

DNA Hypermethylation Induced by L-Methionine Leads to Oligodendroglial and Myelin Deficits and Schizophrenia-Like Behaviors in Adolescent Mice

Frontiers in Neuroscience, 2021
Increasing evidence has demonstrated that in addition to dysfunction of neuronal circuitry, oligodendroglial dysfunction and/or disruption of white matter integrity are found in the brains of patients with schizophrenia.
Xianjun Chen, Xianjun Chen, Nan-Xin Huang, Yong-Jie Cheng, Qi-Yan Cai, Yan-Ping Tian, Xing-Shu Chen, Xing-Shu Chen, Lan Xiao   +8 more
doaj   +1 more source

Live-cell metabolic analysis of oligodendroglia isolated from postnatal mouse brain and spinal cord

STAR Protocols, 2022
Summary: This protocol describes isolation and live-cell metabolic analysis of O4+ oligodendroglia from brain and spinal cord of postnatal mice. We have optimized existing protocols for O4+ isolation from neonatal brain and expanded the protocol to ...
Luipa Khandker, Teresa L. Wood
doaj   +1 more source

Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes [PDF]

Diabetes & Metabolism Journal, 2022
As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis.
Xiaolong Li, Yan Cai, Zuo Zhang, Jiyin Zhou   +3 more
doaj   +1 more source

Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits

Nature Communications, 2020
Myelination optimizes conduction speed of excitatory neurons. However, whether myelination of interneurons (INs) refines cortical networks is unclear.
Najate Benamer, Marie Vidal, Maddalena Balia, María Cecilia Angulo   +3 more
doaj   +1 more source