Results 11 to 20 of about 15,205 (212)

Mosaic subventricular origins of forebrain oligodendroglia [PDF]

Frontiers in Neuroscience, 2016
In the perinatal as well as the adult CNS, the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates neurons and oligodendrocytes (OLs), the myelin forming cells of the CNS.
Kasum eAzim, Benedikt eBerninger, Olivier eRaineteau   +2 more
doaj   +3 more sources

Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression. [PDF]

Glia
Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Peiró-Moreno C, Chara JC, Marshall-Phelps K, Ugarte-Arakistain I, Calovi S, De Almeida RG, Domercq M, Matute C.   +7 more
europepmc   +3 more sources

Oligodendroglial Densities and Myelin Structure Are Altered in TDP-43 Related Amyotrophic Lateral Sclerosis. [PDF]

Glia
TDP‐43Q331K mice exhibit altered proliferative dynamics in oligodendrocytes and their precursors. Oligodendroglial cell death is evident in TDP‐43Q331K mice. TDP‐43Q331K mice display altered myelin reflectance and pathology in the spinal cord. ABSTRACT Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the ...
Lewis KN, Craig GA, Mason J, Tomas D, Cuic B, Walker AK, Gonsalvez DG, Turner BJ, Barton SK.   +8 more
europepmc   +2 more sources

An Autopsy Case With Fragile X-Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System. [PDF]

Neuropathology
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Shioya A, Ishii K, Sato T, Noguchi M, Tamaoka A, Saito Y.   +5 more
europepmc   +2 more sources

DNA Hypermethylation Induced by L-Methionine Leads to Oligodendroglial and Myelin Deficits and Schizophrenia-Like Behaviors in Adolescent Mice

Frontiers in Neuroscience, 2021
Increasing evidence has demonstrated that in addition to dysfunction of neuronal circuitry, oligodendroglial dysfunction and/or disruption of white matter integrity are found in the brains of patients with schizophrenia.
Xianjun Chen, Xianjun Chen, Nan-Xin Huang, Yong-Jie Cheng, Qi-Yan Cai, Yan-Ping Tian, Xing-Shu Chen, Xing-Shu Chen, Lan Xiao   +8 more
doaj   +1 more source

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia [PDF]

J Neurosci Res
This study shows that the blood‐derived molecule, Fibrinogen, has a differential effect on human Oligodendroglial (OL) cells. Fibrinogen, when added in vitro, leads to aberrant differentiation of OL‐precursors towards an astrocytic fate. On the other hand, when added into the culture of mature OLs, fibrinogen increases myelination capacity.
Blaszczyk G, Weng C, Mohammadnia A, Cui Q, Giurleo A, Groh A, Plouffe C, Sirois J, Piscopo V, Yaqubi M, Taqvi A, Cassidy E, Martin L, Hall J, Dudley R, Srour M, Zandee S, Klement W, Larouche S, Prat A, Durcan T, Stratton J, Antel J, Moore G.   +23 more
europepmc   +2 more sources

Live-cell metabolic analysis of oligodendroglia isolated from postnatal mouse brain and spinal cord

STAR Protocols, 2022
Summary: This protocol describes isolation and live-cell metabolic analysis of O4+ oligodendroglia from brain and spinal cord of postnatal mice. We have optimized existing protocols for O4+ isolation from neonatal brain and expanded the protocol to ...
Luipa Khandker, Teresa L. Wood
doaj   +1 more source

Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes [PDF]

Diabetes & Metabolism Journal, 2022
As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis.
Xiaolong Li, Yan Cai, Zuo Zhang, Jiyin Zhou   +3 more
doaj   +1 more source

Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits

Nature Communications, 2020
Myelination optimizes conduction speed of excitatory neurons. However, whether myelination of interneurons (INs) refines cortical networks is unclear.
Najate Benamer, Marie Vidal, Maddalena Balia, María Cecilia Angulo   +3 more
doaj   +1 more source

Distinct patterns of oligodendroglial dysfunction in neurodegenerative diseases [PDF]

Alzheimers Dement
Abstract Background Oligodendroglia are a major class of glial cell that play critical roles in myelination and neuronal support. Involvement of oligodendroglia is well‐known pathologically in frontotemporal lobar degeneration with tau (FTLD‐tau) and TDP‐43 (FTLD‐TDP) pathology, Alzheimer's disease (AD) and multiple system atrophy (MSA). However, their
Forrest S, Kane M, Knott S, Kovacs G.
europepmc   +2 more sources