Results 101 to 110 of about 61,218 (243)

When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions

Movement Disorders, EarlyView.
Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel, Robert S. Eisinger, Joyce M. Lee, Sarah Hamimi, Hope Kim, Susanna D. Howard, Casey H. Halpern   +6 more
wiley   +1 more source

Macroscale Gradient‐Informed Neural Oscillation Topography in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is characterized by large‐scale disruptions in beta and gamma oscillations. Although subcortical beta power is an established biomarker for current adaptive deep brain stimulation (aDBS), it may not fully capture the global pathophysiological burden and the macroscale hierarchical reorganization of the ...
Hao Ding, Ke Xie, Manuel Bange, Hannah Kühne, Jenny Blech, Bahman Nasseroleslami, Jens Volkmann, Sergiu Groppa, Muthuraman Muthuraman   +8 more
wiley   +1 more source

Quantitative Comparison of Multi‐Echo Spin Echo and Multi‐Echo Gradient Echo Myelin Water Imaging in a Panel of Mbp Enhancer‐Edited Mouse Lines

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate the correspondence between myelin water fraction (MWF) estimates derived from multi‐echo spin echo (MESE) and multi‐echo gradient echo (MGRE) imaging in fixed mouse brain tissue, using a panel of myelin basic protein (Mbp) enhancer‐edited mouse lines exhibiting graded hypomyelination.
Vladimir Grouza, Yawen Shi, Sean Goldfarb, Klaudia M. Bednarz, Isabella Gomez, Marius Tuznik, Zhe Wu, Hooman Bagheri, Katherine A. Siminovitch, Alan C. Peterson, Thomas Stroh, David A. Rudko   +11 more
wiley   +1 more source

Complementary Sensitivity of Fixed‐Time and Fixed‐Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating‐Gradient Diffusion MRI With Ultra‐Strong Gradients

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Oscillating‐gradient spin‐echo (OGSE) diffusion MRI probes cell geometry and membrane integrity through the frequency‐dependence of kurtosis, but prior studies have reported inconsistent findings depending on how frequency is varied. We compared frequency‐dependent kurtosis in the human brain under two regimes: varying frequency with ...
Dongsuk Sung, Kwok‐Shing Chan, Julianna Gerold, Wen Zhong, Jialan Zheng, Qiyuan Tian, Hua Guo, Susie Y. Huang, Hong‐Hsi Lee   +8 more
wiley   +1 more source

EEG Dynamics in Children Before, During and After General Anesthesia

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Age‐specific EEG signatures during anesthesia are described in pediatrics, and perioperative monitoring is increasingly advocated; yet most indices and algorithms derive from adult data and may not generalize to early development. Aims The purpose of this study was to characterize perioperative frontal EEGs in young children younger
Maximilian Markus, Feidias Panagiotou, Claudia Spies, Susanne Koch   +3 more
wiley   +1 more source

Exome Sequencing in Prenatally Diagnosed Isolated Neural Tube Defects: A Subtype‐Specific Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To explore potential genetic contributors across different subtypes of isolated neural tube defects (NTDs) ‐ acrania–exencephaly–anencephaly sequence (AEAS), spinal dysraphism, and encephalocele ‐ using exome sequencing (ES) in a prenatal cohort, with the goal of gaining insight into the molecular diversity underlying these distinct ...
Adi Botvinik, Vered Offen Glasner, Adi Reches, Hadas Miremberg, Karina Krajden Haratz, Tal brill, Liron Malki, Michal Rozenzwaig, Yuval Yaron, Michal Levy   +9 more
wiley   +1 more source

Spatiotemporal Co‐Delivery of Hydrogen and Magnesium via Microneedle Patches for Neuroinflammation Modulation After Spinal Cord Injury: A Multi‐Modal In Vivo Study

Small, EarlyView.
A spatiotemporal co‐delivery microneedle system (MN‐Mg) is developed for spinal cord injury repair. By generating hydrogen gas and magnesium ions in situ, this dual‐engine platform effectively scavenges ROS and modulates microglial polarization via the MAPK/AP‐1 signaling axis.
Haibo Wang, Yang Sun, Shiqi Wang, Wenbo Wang, Jincheng Tang, Ziang Li, Xinzhao Jiang, Liang Zhou, Jie Wu, Qiangqiang Guo, Yiwei Zhu, Yu Feng, Kun Xi, Liang Chen   +13 more
wiley   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

Cognitive and Psychomotor Processing Speed in Medication‐Naïve Individuals With First‐Episode of Psychosis: The Role of Peripheral Inflammatory Markers

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background and Hypothesis Deficits in processing speed (PS) and psychomotor speed (PMS) are core cognitive impairments in schizophrenia spectrum disorders, including first‐episode psychosis (FEP). Neuroinflammation has been proposed as a potential contributor to these deficits.
Ángel Yorca‐Ruiz, Carlos Martínez Asensi, Rebeca Magdaleno Herrero, Alexandre Díaz‐Pons, Víctor Ortiz‐García de la Foz, Luis Manuel Fernández Cacho, Ana Catalán Alcantara, Benedicto Crespo‐Facorro, Rosa Ayesa‐Arriola   +8 more
wiley   +1 more source

Integrated Methylome–Transcriptome Analysis Reveals Epigenomic Remodeling and Rho GTPase–Linked Immune–Epithelial Crosstalk in Atopic Dermatitis

Allergy, EarlyView.
Integrated methylome–transcriptome–microbiome analysis of AD skin identified thousands of DMRs. Rho GTPase signaling and actin–junctional programs emerged as central hubs integrating immune, epithelial, and microbial interactions in the pathogenesis of atopic dermatitis.
Tiina Skoog, Ying Yang, Peter Olah, Shintaro Katayama, Piia Karisola, Catherine Smith, Stephan Weidinger, Jonathan Barker, Antti Lauerma, Björn Andersson, Bernhard Homey, Nanna Fyhrquist, Juha Kere, Harri Alenius, MAARS Consortium, Francesca Levi‐Schaffer, Dario Greco, Stefanie Prast‐Nielsen, Vassili Soumelis, Sophia Tsoka, Jens M. Schröder, Frank O. Nestle, Philippe Hupé   +22 more
wiley   +1 more source