Results 101 to 110 of about 108,757 (334)

Fast-spiking Parvalbumin Interneurons are Frequently Myelinated in the Cerebral Cortex of Mice and Humans [PDF]

, 2017
Myelination, the insulating ensheathment of axons by oligodendrocytes, is thought to both optimize signal propagation and provide metabolic support. Despite the well-established physiological importance of myelination to neuronal function, relatively ...
Brizee, D. (D.), Couey, J.J. (Jonathan J), Dirven, C.M.F. (Clemens), Hosseini, B., Houtsmuller, A.B. (Adriaan), Kushner, S.A. (Steven), Shpak, G. (Guy), Slotman, J.A. (Johan A.), Stedehouder, J. (Jeffrey)   +8 more
core   +4 more sources

Spotted around the web: Sharing games; myelination; neuroscience prizes [PDF]

, 2023
Jill Adams
openalex   +1 more source

gnSPADE: Incorporating Gene Network Structures Enhances Reference‐Free Deconvolution in Spatial Transcriptomics

Advanced Intelligent Systems, EarlyView.
gnSPADE integrates gene‐network structures into a probabilistic topic modeling framework to achieve reference‐free cell‐type deconvolution in spatial transcriptomics. By embedding gene connectivity within the generative process, gnSPADE enhances biological interpretability and accuracy across simulated and real datasets, revealing spatial organization ...
Aoqi Xie, Yuehua Cui
wiley   +1 more source

Defective myelination in an RNA polymerase III mutant leukodystrophic mouse

, 2021
Emilio Merheb, Min-Hui Cui, Juwen C. DuBois, Craig A. Branch, Maria Gulinello, Bridget Shafit‐Zagardo, Robyn D. Moir, Ian M. Willis   +7 more
openalex   +2 more sources

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source

Insights into organelle forming RNAs: Diversity, functions and future perspectives

Animal Models and Experimental Medicine, EarlyView.
RNA molecules play crucial roles in the formation and maintenance of cellular structures and organelles. These ‘organelle formation RNAs’ include ribosomal RNAs, paraspeckle‐forming RNAs, nuclear speckle‐forming RNAs, nucleolus‐forming RNAs, and cytoskeleton‐forming RNA.
Meng Gong, Xiangting Wang, Xiaolin Liang
wiley   +1 more source

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

Annals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff, Alexander Schulz, Christian Hagel, Robert Büttner, Michael Reuter, Waylan K. Bessler, D. Wade Clapp, Helen Morrison   +7 more
wiley   +1 more source

Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro. [PDF]

, 2019
BackgroundOligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS.
Biswas, Sangita, Chechneva, Olga, Deng, Wenbin, Mayrhofer, Florian, Namchaiw, Poommaree, Wen, Han   +5 more
core  

A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination

, 2023
Ana I. Seixas, Miguel R. G. Morais, Cord Brakebusch, João B. Relvas   +3 more
openalex   +1 more source

PAK1 Positively Regulates Oligodendrocyte Morphology and Myelination [PDF]

, 2021
Tanya L. Brown, H Hashimoto, Lisbet T. Finseth, Teresa L. Wood, Wendy B. Macklin   +4 more
openalex   +1 more source