Results 191 to 200 of about 77,821 (298)

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source

MRI-Based Quantitative Assessment of Normal-Appearing White and Gray Matter Demyelination in Multiple Sclerosis, Parkinson's Disease, Long COVID, and Normal Aging. [PDF]

Biomedicines
Khodanovich M, Svetlik M, Kamaeva D, Usova A, Anan'ina T, Wasserlauf I, Shadrina M, Pashkevich V, Moshkina M, Obukhovskaya V, Kataeva N, Levina A, Alifirova V, Titova M, Zhukova I, Vasilieva S, Schastnyy E, Tumentceva YA, Yarnykh V.   +18 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Molecular cues from distinct neuron classes drive differential myelination in the neocortex. [PDF]

Dev Cell
Domínguez-Iturza N, Jokhi V, Kim K, Shetty AS, Di Bella DJ, Pereira Luppi M, Yuan W, Abbate C, Oyler-Castrillo P, Oliver NA, Venkat V, Jin X, Simmons S, Levin JZ, Brown JR, Arlotta P.   +15 more
europepmc   +1 more source

Virus‐specific alterations in placental structure and transporter expression following maternal arbovirus infection

The Journal of Physiology, EarlyView.
Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade, Enrrico Bloise, Natália L. Silva, Jair R. S. Braga, Sharton V. A. Coelho, Veronica M. O. Nascimento, Guinever E. Imperio, Camila O. S. Nunes, Antônio J. L. A. Cunha, Marcelo A. Pascoal‐Xavier, Luciana B. Arruda, Arnaldo Prata‐Barbosa, Kristin L. Connor, Tania M. Ortiga‐Carvalho   +13 more
wiley   +1 more source

Schwann Cell Activity in the Multiple Sclerosis Microenvironment. [PDF]

Cells
Shurin MR, Shurin GV, Doyle CM, Lokshin AE, Wheeler SE.   +4 more
europepmc   +1 more source

Characterization of postnatal brain injury and behavioural deficits in a rat model of placental insufficiency‐induced fetal growth restriction

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal growth restriction (FGR) is a common pregnancy complication associated with long‐term neurodevelopmental impairments. Using the reduced uterine perfusion pressure (RUPP) rat model of placental insufficiency‐induced FGR, this study demonstrates that FGR leads to persistent anatomical, histological and behavioural ...
Judit Alhama‐Riba, Caroline G. M. de Theije, Valentina Salvi, Dominique Viveen, Sebastiaan W. T. Corstjens, Marijke. E. J. Achterberg, Yohan van de Looij, Freek E. Hoebeek, Cora H. A. Nijboer   +8 more
wiley   +1 more source

Mice lacking two alleles of the schizophrenia risk gene <i>Tcf4</i> and <i>Olig2</i> display deficits in anxiety-related behavior, sensorimotor gating, and cognition. [PDF]

Front Cell Neurosci
Chang MH, Li R, Stephan M, Schmitt A, Falkai P, Rossner MJ.   +5 more
europepmc   +1 more source

Prenatal air pollution exposure is associated with altered neurodevelopmental outcomes in early childhood

The Journal of Physiology, EarlyView.
Abstract figure legend This study examined the effect of modelled maternal air pollution exposure during gestation on neurodevelopment in a community cohort of 498 toddlers recruited from Greater London, UK. Higher 1st trimester exposure to particulate matter and nitrogen dioxide was associated with lower language scores at 18 months adjusting for ...
Alexandra F. Bonthrone, Brendan Bos, Ben Barratt, Hoi Ching Olina Pang, Sean Beevers, Andrew Chew, Shona Falconer, Joseph V. Hajnal, Frank J. Kelly, Chiara Nosarti, A. David Edwards, Serena J. Counsell   +11 more
wiley   +1 more source

CX3CL1/CX3CR1-dependent microglial phagocytosis of oligodendrocyte precursor cells contributes to sevoflurane-induced myelination impairments in neonatal mice. [PDF]

J Neuroinflammation
Lv J, Xia Z, Wang X, Zhao P, Wu Z.
europepmc   +1 more source