Results 221 to 230 of about 72,448 (306)

Exploratory analysis of high-altitude effects on brain morphology and myelination in native Tibetan infants. [PDF]

Transl Pediatr
Ze B, Chen J, Zhao R, Zeng Y, Cidan W, Zhou Q, Cao Z, Hua R, Shi F, Hu L, Yan K, Cheng G, Wu D, Liu J, Zhou W.   +14 more
europepmc   +1 more source

miniMORPH: A Morphometry Pipeline for Low‐Field MRI in Infants

Human Brain Mapping, Volume 47, Issue 9, June 15, 2026.
miniMORPH is a fully automated pipeline for extracting regional brain volumes from ultra‐low‐field (0.064 T) infant MRI without super‐resolution. Benchmarking against high‐field references shows it preserves between‐subject variation and yields face‐valid developmental and birthweight‐related effects, enabling scalable neurodevelopmental morphometry ...
Chiara Casella, Aksel Leknes, Niall J. Bourke, Ayo Zahra, Daniel Cromb, Dora Barnes, Alejandra Martin Segura, Flora Silvester, Vanessa Kyriakopoulou, Daniel Elijah Scheiene, Simone R. Williams, Layla E. Bradford, Joanitta Murungi, Steven C. R. Williams, Sean C. L. Deoni, Victoria Nankabirwa, Kirsten A. Donald, Muriel M. K. Bruchhage, Jonathan O'Muircheartaigh   +18 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, Volume 600, Issue 12, Page 1699-1716, June 2026.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Early-life gastrointestinal inflammation and the developing brain: Unravelling the pathways to long-term cognitive dysfunction. [PDF]

World J Clin Pediatr
Al-Beltagi M, Saeed NK, El-Sawaf Y, Bediwy AS, Elbeltagi R.   +4 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life. [PDF]

Adv Sci (Weinh)
Lynch CMK, Knox EG, Soong D, Bastiaanssen TFS, Trontti K, Tofani GSS, Ivaschuk S, Collins MK, Arafa D, Nagpal J, Hovatta I, Lyons DA, Clarke G, Cryan JF.   +13 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The cumulative impact of seizures: the science underlying how seizures beget seizures. [PDF]

Front Neurol
Gustin RM, Gholipour T, Peters JM.
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Chemogenetic Schwann cell activation impairs early myelination and triggers adult demyelination in the peripheral nervous system. [PDF]

Front Cell Neurosci
Corral JG, Cheli VT, Santiago-Gonzalez DA, Kedari KG, Paez PM.   +4 more
europepmc   +1 more source