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Myelination in the absence of myelin-associated glycoprotein
Nature, 1994The hypothesis that myelin-associated glycoprotein (MAG) initiates myelin formation is based in part on observations that MAG has an adhesive role in interactions between oligodendrocytes and neurons. Furthermore, the over- or underexpression of MAG in transfected Schwann cells in vitro leads to accelerated myelination or hypomyelination, respectively.
C, Li +7 more
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Myelination and Retarded Myelination
1989Flechsig (1920) was the originator of the view that the degree of myelination of the central nervous system might be correlated with functional capacity. In his theory he stated that myelination started in projection pathways before association pathways, in peripheral nerves before central pathways, and in sensory areas before motor ones.
Jacob Valk, Marjo S. van der Knaap
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Current Opinion in Neurobiology, 1993
Myelin formation and maintenance requires complex interactions between neurons and glia, and between the integral protein and lipid components of the myelin sheath. Many of the underlying mechanisms may be examined by studying the perturbations caused by spontaneous and targeted mutations in myelin protein genes.
G J, Snipes, U, Suter, E M, Shooter
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Myelin formation and maintenance requires complex interactions between neurons and glia, and between the integral protein and lipid components of the myelin sheath. Many of the underlying mechanisms may be examined by studying the perturbations caused by spontaneous and targeted mutations in myelin protein genes.
G J, Snipes, U, Suter, E M, Shooter
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1997
Although it is well known that the central nervous system (CNS) and the peripheral nervous system (PNS), and in particular their myelin, contain large quantities of cholesterol, the specific role of this lipid in the structure and function of the nervous system remains elusive. In this review, we will summarize progress in our understanding of the role
G J, Snipes, U, Suter
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Although it is well known that the central nervous system (CNS) and the peripheral nervous system (PNS), and in particular their myelin, contain large quantities of cholesterol, the specific role of this lipid in the structure and function of the nervous system remains elusive. In this review, we will summarize progress in our understanding of the role
G J, Snipes, U, Suter
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Current Protocols in Cell Biology, 2006
AbstractThe methods used to prepare myelin involve homogenization of the tissue in isotonic sucrose solution, followed by the isolation of myelin membranes by a series of steps that include density gradient centrifugation and differential centrifugation. Homogenization of nervous tissue in isotonic sucrose causes the myelin sheath to peel from the axon
Jorge N, Larocca, Williams T, Norton
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AbstractThe methods used to prepare myelin involve homogenization of the tissue in isotonic sucrose solution, followed by the isolation of myelin membranes by a series of steps that include density gradient centrifugation and differential centrifugation. Homogenization of nervous tissue in isotonic sucrose causes the myelin sheath to peel from the axon
Jorge N, Larocca, Williams T, Norton
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Morphology of Myelin and Myelination
1984Myelin is a membrane characteristic of nervous tissue, laid down in segments along selected nerve fibers, that functions as an insulator to increase the velocity of stimuli being transmitted between a nerve-cell body and its target. While well documented in several invertebrates (annelids and crustaceans) in which it exists in its peripheral nervous ...
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The anatomy and biochemistry of myelin and myelination
Operative Techniques in Orthopaedics, 2004Despite advances in peripheral nerve repair techniques, complete functional recovery is seldom achieved. To understand the nerve’s regenerative capacity, it is necessary to understand its developmental and functional anatomy and its cellular constituents.
Laura S. Rummler +2 more
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Neurologic Clinics, 1995
Although it was initially thought to be a passive structure, the oligodendrocyte and myelin unit is now considered highly dynamic with many important functions beyond its role in myelination. Inhibitors of neurite growth can be localized to oligodendrocyte and myelin, highlighting the importance of oligodendrocytes in general CNS maintenance and in ...
J A, McLaurin, V W, Yong
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Although it was initially thought to be a passive structure, the oligodendrocyte and myelin unit is now considered highly dynamic with many important functions beyond its role in myelination. Inhibitors of neurite growth can be localized to oligodendrocyte and myelin, highlighting the importance of oligodendrocytes in general CNS maintenance and in ...
J A, McLaurin, V W, Yong
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Molecular and Cellular Biochemistry, 1973
We have presented a resume of recent investigations of the biochemistry of glycolipids and glycoproteins in the developing nervous system. The novel observations and advances in these areas coupled with relevant studies on the metabolism of myelin basic protein provide a basis for the development of a hypothesis regarding the formation of the myelin ...
R O, Brady, R H, Quarles
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We have presented a resume of recent investigations of the biochemistry of glycolipids and glycoproteins in the developing nervous system. The novel observations and advances in these areas coupled with relevant studies on the metabolism of myelin basic protein provide a basis for the development of a hypothesis regarding the formation of the myelin ...
R O, Brady, R H, Quarles
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