Results 121 to 130 of about 1,098 (144)

Dioxygenation of tryptophan residues by superoxide and myeloperoxidase. [PDF]

J Biol Chem
Dickerhof N, Ashby LV, Ford D, Dilly JJ, Anderson RF, Payne RJ, Kettle AJ.   +6 more
europepmc   +1 more source

Neutrophils and neutrophil extracellular traps: double-edged swords in cancer pathophysiology and therapy resistance. [PDF]

Cell Commun Signal
Shen Y, Fang H, Xie H, Zhu S, Wang X, Liu S, Sui J, Xu Y, Bo Y, Zhao J, Jin J, Du J, Huang P.   +12 more
europepmc   +1 more source

Genomic organization and chromosomal localization of mouse proteinase 3 (Myeloblastin)

Mammalian Genome, 1999
Proteinase 3 (PR3), is a matrix-degrading serine proteinase expressed in different hematopoietic cell lineages. The PR3 protein appears to regulate the myeloid differentiation and was found to be the autoantigen associated with Wegener granulomatosis.
A. Belaaouaj, J. Just, Anne Houzel-Charavel, Steven D. Shapiro   +3 more
openalex   +3 more sources

Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells

British Journal of Haematology, 1995
Summary. Proteinase 3 (P3) is a serine proteinase present in the primary granules of neutrophils. We have investigated the expression of this protein in samples of bone marrow from healthy individuals and patients with different types of leukaemias by using immunocytochemical staining and flow cytometric quantitation.
Robert J. Dengler, Ursula Münstermann, S. Al-Batran, Irmela Hausner, Stefan Faderl, Christoph Nerl, Bertold Emmerich   +6 more
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Abstract 4794: Kras mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma

Cancer Research, 2012
Abstract Background Lung cancer is the leading cause of all cancer deaths worldwide with suboptimal prognosis and treatment options. Therefore we aimed to identify molecular characteristics with a predictive clinical utility that at the same time might represent novel therapeutic targets for human lung adenocarcinoma.
Sven Hillinger, Thomas Wiedl, Stéphane Collaud, Stephan Arni, Peter Schraml, Alex Soltermann, Holger Moch, Walter Weder   +7 more
openalex   +2 more sources

Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells

Journal of Cellular Physiology, 1998
When HL60 cells are exposed to 1,25-dihydroxyvitamin D3 (1,25D3), they undergo changes approximating the phenotype of the monocyte. Little is known, however, about the regulation and the mechanisms of this transition. It was previously noted that DNA binding by the Sp1 transcription factor in nuclear extracts of HL60 cells is profoundly altered when ...
Jia Rao, Fan Zhang, Robert Donnelly, Neil L. Spector, George P. Studzinski   +4 more
openalex   +3 more sources

Detection of Significantly Increased Frequencies of Proteinase-3 (Myeloblastin) - Specific CD8+ T-Cells in Patients with De Novo Diagnosed Hepatitis C and Infiltration of Liver Tissue with Proteinase 3 Overexpressing Mononuclear Cells.

Blood, 2004
Abstract Proteinase 3 (PR3), also referred to as myeloblastin, is a 26kD serine protease which is overexpressed in precursor cells of chronic myeloid leukaemia (CML). PR3 has previously been identified as the autoantigen of Wegener’s granulomatosis, which is characterized by a self-destructive humoral and T-cell response against PR3 ...
Andreas Burchert, Thomas Berg, Markus Ritter, Peter Barth, Andreas Neubauer   +4 more
openalex   +2 more sources

A myeloblastin/proteinase-3 cDNA clone identifies a BglII and a PvuII restriction fragment length polymorphism

Human Genetics, 1993
A myeloblastin/proteinase-3 (MBN/PR-3) cDNA probe detects two bi-allelic (BglII, PvuII) DNA polymorphisms. These restriction fragment length polymorphisms provide new genetic markers on chromosome 19.
Jürg Schwaller, T. Chen, Martin F. Fey, A Tobler   +3 more
openalex   +3 more sources

Myeloblastin/Proteinase 3 Belongs to the Set of Negatively Regulated Primary Response Genes Expressed During in Vitro Myeloid Differentiation

Biochemical and Biophysical Research Communications, 1994
Regulation of myeloblastin expression was studied during myeloid differentiation of HL60 cells and compared with that of myeloperoxidase. Induction towards the monocytic pathway of differentiation caused a rapid, marked and parallel down-regulation of both transcripts which were insensitive to cycloheximide. Thus, myeloblastin is directly regulated and,
T. Chen, Roland Meier, Andrew Ziemiecki, Martin F. Fey, A Tobler   +4 more
openalex   +3 more sources

Proteinase 3/myeloblastin as a growth factor in human kidney cells.

Journal of nephrology, 2004
Numerous data support the possible role of myeloblastin/proteinase 3 (PR3) in growth and differentiation of neutrophil granulocytes and certain monocyte subtypes. However, whether PR3 is expressed in non-myeloid cells remains a matter of debate even though recent studies clearly demonstrated its expression in endothelium, kidney epithelial cells and ...
Manfred Relle, Werner J. Mayet, Dennis Strand, Walburgis Brenner, Peter R. Galle, Andreas Schwarting   +5 more
openalex   +2 more sources