Results 131 to 140 of about 1,083 (144)

Myeloblastin

1998
Dietmar Schomburg, Dörte Stephan
exaly   +2 more sources

Myeloblastin

2013
Narayanam V Rao, John R Hoidal
exaly   +2 more sources

Myeloblastin

2008
exaly   +2 more sources

Genomic organization and chromosomal localization of mouse proteinase 3 (Myeloblastin)

Mammalian Genome, 1999
Proteinase 3 (PR3), is a matrix-degrading serine proteinase expressed in different hematopoietic cell lineages. The PR3 protein appears to regulate the myeloid differentiation and was found to be the autoantigen associated with Wegener granulomatosis.
A, Belaaouaj, C, Moog-Lutz, J, Just, A, Houzel-Charavel, S D, Shapiro, Y, Cayre   +5 more
openaire   +2 more sources

Proteinase 3/myeloblastin as a growth factor in human kidney cells

Journal of Nephrology, 2003
Abstract Background: Numerous data support the possible role of myeloblastin/proteinase 3 (PR3) in growth and differentiation of neutrophil granulocytes and certain monocyte subtypes. However, whether PR3 is expressed in nonmyeloid cells remains a matter of debate even though recent studies clearly demonstrated its expression in ...
Manfred, Relle, Werner J, Mayet, Dennis, Strand, Walburgis, Brenner, Peter R, Galle, Andreas, Schwarting   +5 more
openaire   +2 more sources

Characterization of cDNA clones encoding mouse proteinase 3 (myeloblastine) and cathepsin G

Immunogenetics, 1997
Serine proteases are the most abundant granule constituents of several major hematopoietic cell lineages. Due to their high abundance and their strict tissue specificity they have become important phenotypic cell markers used for studies of various aspects of hematopietic cell development.
M, Aveskogh, C, Lützelschwab, M R, Huang, L, Hellman   +3 more
openaire   +2 more sources

Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells

British Journal of Haematology, 1995
Summary. Proteinase 3 (P3) is a serine proteinase present in the primary granules of neutrophils. We have investigated the expression of this protein in samples of bone marrow from healthy individuals and patients with different types of leukaemias by using immunocytochemical staining and flow cytometric quantitation.
R, Dengler, U, Münstermann, S, al-Batran, I, Hausner, S, Faderl, C, Nerl, B, Emmerich   +6 more
openaire   +2 more sources

Abstract 4794: Kras mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma

Cancer Research, 2012
Abstract Background Lung cancer is the leading cause of all cancer deaths worldwide with suboptimal prognosis and treatment options. Therefore we aimed to identify molecular characteristics with a predictive clinical utility that at the same time might represent novel therapeutic targets for human lung adenocarcinoma.
Sven Hillinger, Thomas Wiedl, Stephane Collaud, Stephan Arni, Peter Schraml, Alex Soltermann, Holger Moch, Walter Weder   +7 more
openaire   +1 more source

Detection of Significantly Increased Frequencies of Proteinase-3 (Myeloblastin) - Specific CD8+ T-Cells in Patients with De Novo Diagnosed Hepatitis C and Infiltration of Liver Tissue with Proteinase 3 Overexpressing Mononuclear Cells.

Blood, 2004
Abstract Proteinase 3 (PR3), also referred to as myeloblastin, is a 26kD serine protease which is overexpressed in precursor cells of chronic myeloid leukaemia (CML). PR3 has previously been identified as the autoantigen of Wegener’s granulomatosis, which is characterized by a self-destructive humoral and T-cell response against PR3 ...
Andreas Burchert, Thomas Berg, Markus Ritter, Peter Barth, Andreas Neubauer   +4 more
openaire   +1 more source

[Effect of translocation t(15;17) on the gene expression regulation of myeloblastin during all trans retinoic acid induced myeloid differentiation in human leukemic cells].

Comptes rendus des seances de la Societe de biologie et de ses filiales, 1996
Myeloblastin (mbn) is a serine protease involved in the control of growth and differentiation of human leukemic cells. In the promyelocytic-like human leukemia cell line HL-60 this protease is inhibited during retinoic acid (RA) induced differentiation. The t(15;17) translocation, specifically associated with the human acute promyelocytic leukemia (APL)
P, Ballerini, F, Besançon, Y E, Cayre
openaire   +1 more source