Results 31 to 40 of about 115 (67)

Functional analysis of the NUP98-CCDC28A fusion protein

Haematologica, 2012
Background The nucleoporin gene NUP98 is rearranged in more than 27 chromosomal abnormalities observed in childhood and adult, de novo and therapy-related acute leukemias of myeloid and T-lymphoid origins, resulting in the creation of fusion genes and ...
Arnaud Petit, Christine Ragu, Gwendoline Soler, Chris Ottolenghi, Caroline Schluth, Isabelle Radford-Weiss, Sylvie Schneider-Maunoury, Isabelle Callebaut, Nicole Dastugue, Harry A. Drabkin, Olivier A. Bernard, Serge Romana, Virginie Penard-Lacronique   +12 more
doaj   +1 more source

METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA

Медицинская иммунология, 2014
. We examined metabolic status of blood lymphocytes in forty-four patients with chronic myeloid leukemia (CML), and in fifty-seven patients with chronic lymphoid leukemia (CLL).
O. V. Smirnova, V. T. Manchuk, A. A. Savchenko   +2 more
doaj   +1 more source

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice. [PDF]

PLoS ONE, 2012
Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, which results from the chromosomal translocation t(10;
Mai Suzuki, Hirokazu Tanaka, Akira Tanimura, Kenji Tanabe, Natsuko Oe, Shinya Rai, Syunsuke Kon, Manabu Fukumoto, Kohji Takei, Takaya Abe, Itaru Matsumura, Yuzuru Kanakura, Toshio Watanabe   +12 more
doaj   +1 more source

Genetic evidence for predisposition to acute leukemias due to a missense mutation (p.Ser518Arg) in ZAP70 kinase: a case-control study

BMC Medical Genomics
Background The apparent lack of additional missense mutations data on mixed-phenotype leukemia is noteworthy. Single amino acid substitution by these non-synonymous single nucleotide variations can be related to many pathological conditions and may ...
Khalil Khashei Varnamkhasti, Samire Khashei Varnamkhasti, Atefeh Shahrouzian, Masoomeh Rahimzadeh, Leila Naeimi, Behrouz Naeimi, Sirous Naeimi   +6 more
doaj   +1 more source

The Biochemical Properties and Functions of CALM and AP180 in Clathrin Mediated Endocytosis

Membranes, 2014
Clathrin-mediated endocytosis (CME) is a fundamental process for the regulated internalization of transmembrane cargo and ligands via the formation of vesicles using a clathrin coat.
Lia Moshkanbaryans, Ling-Shan Chan, Mark E. Graham   +2 more
doaj   +1 more source

Ubiquitous expression of MAKORIN-2 in normal and malignant hematopoietic cells and its growth promoting activity.

PLoS ONE, 2014
Makorin-2 (MKRN2) is a highly conserved protein and yet its functions are largely unknown. We investigated the expression levels of MKRN2 and RAF1 in normal and malignant hematopoietic cells, and leukemia cell lines.
King Yiu Lee, Kathy Yuen Yee Chan, Kam Sze Tsang, Yang Chao Chen, Hsiang-fu Kung, Pak Cheung Ng, Chi Kong Li, Kam Tong Leung, Karen Li   +8 more
doaj   +1 more source

Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity

Frontiers in Immunology, 2020
Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities of cytotoxic lymphoid cells.
Inna M. Yasinska, N. Helge Meyer, Stephanie Schlichtner, Rohanah Hussain, Giuliano Siligardi, Maxwell Casely-Hayford, Walter Fiedler, Jasmin Wellbrock, Cloe Desmet, Luigi Calzolai, Luca Varani, Steffen M. Berger, Ulrike Raap, Bernhard F. Gibbs, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Elizaveta Fasler-Kan, Vadim V. Sumbayev   +17 more
doaj   +1 more source

The spatial and multi-omic landscape of Down syndrome leukemogenesis: moving beyond cellular heterogeneity

Experimental Hematology & Oncology
Down syndrome (DS) confers a developmentally rooted predisposition to both myeloid and lymphoid leukemias, particularly myeloid leukemia associated with DS (ML-DS) and acute lymphoblastic leukemia associated with DS (ALL-DS). While trisomy 21-driven gene
Edoardo Peroni, Rosario Amato, Martina Bado, Mosè Favarato, Antonio Rosato   +4 more
doaj   +1 more source

Chimeric T-cell receptors: new challenges for targeted immunotherapy in hematologic malignancies

Haematologica, 2007
Chimeric T-cell receptors (ChTCR) are a fascinating technological step in the field of immunotherapy for orienting the activity of immune cells towards specific molecular targets expressed on the cell surface of various tumors, including hematologic ...
Ettore Biagi, Virna Marin, Greta Maria Paola Giordano Attianese, Erica Dander, Giovanna D’Amico, Andrea Biondi   +5 more
doaj   +1 more source

From the biology of PP2A to the PADs for therapy of Hematologic malignancies

Frontiers in Oncology, 2015
Over the past decades, an emerging role of phosphates in the pathogenesis of hematologic malignancies and solid tumors has been established. The tumor suppressor Protein phosphatase 2A (PP2A) belongs to the serine-threonine phosphatases family and ...
Maria eCiccone, George eCalin, Danilo ePerrotti   +2 more
doaj   +1 more source