Results 101 to 110 of about 3,692,049 (193)
International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg +4 more
wiley +1 more source
Frontiers in OncologyLeukemia remains a major clinical challenge due to high rates of drug resistance and recurrence, necessitating the identification of novel therapeutic targets.
Xu Wang +8 more
doaj +1 more source
Superantigens in Cancer Immunotherapy: Mechanisms, Engineering Strategies, and Therapeutic Potential
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Schematic overview of superantigen‐mediated antitumor immune responses and immune suppression within the tumor microenvironment. (1) Antigen‐presenting cells activate T cells through MHC‐II/TCR interactions resulting in the production of cytokines (2) The pro‐inflammatory cytokines released by activated immune cells stimulate downstream immune ...
Urooj Yousaf Virk +5 more
wiley +1 more source
, 1993 This is an interim report of two National studies of human recombinant interferon-alpha 2a (ROFERON-A) in Ph+ chronic myeloid leukemia (CML). The first study (1986-1988) enrolled 322 patients who were randomized to treatment by IFN or by hydroxyurea ...
The Italian Cooperative Study Group on Chronic Myeloid Leukemia +1 more
core +1 more source
HemaSphereTranscriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized the ETO2 regulome by integrating transcriptomic and chromatin binding analyses in human erythroleukemia xenografts and controlled ETO2 depletion
Alexandre Fagnan +25 more
doaj +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger +7 more
wiley +1 more source
The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo +5 more
wiley +1 more source
BET bromodomain proteins; myeloid-lymphoid or mixed-lineage leukemia 3 (MLL3) [PDF]
Science-Business eXchange, 2014 openaire +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.The high expression of PRMT7 enhances its interaction with DVL2 by methylating arginine residues on FOXK1/FOXK2. This process promotes the nuclear translocation of DVL2, thereby aberrantly activating the Wnt/β‐catenin signalling pathway, which ultimately drives the development of doxorubicin resistance in DLBCL.
Xiaoyan Zhao +7 more
wiley +1 more source
MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter
Frontiers in Pharmacology5-Lipoxygenase (5-LO), encoded by the gene ALOX5, is implicated in several pathologies. As key enzyme in leukotriene biosynthesis, 5-LO plays a central role in inflammatory diseases, but the 5-LO pathway has also been linked to development of certain ...
Marius Hyprath +4 more
doaj +1 more source