Results 31 to 40 of about 477,278 (318)

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Nature Communications, 2016
Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their ...
Charlotte L. Scott, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, Chloé Abels, Steve Schoonooghe, Geert Raes, Nick Devoogdt, Bart N. Lambrecht, Alain Beschin, Martin Guilliams   +13 more
doaj   +1 more source

Immunophenotypic Aberrancies in Acute Leukemia: A Tertiary Care Centre Experience

Oman Medical Journal, 2021
Objectives: Acute leukemias (AL) are a heterogeneous group of hematological malignancies with the presence of 20% or more blasts in the peripheral blood or bone marrow.
Monika Gupta, Lovekesh Monga, Dimple Mehrotra, Sonia Chhabra, Shivani Singhal, Rajeev Sen   +5 more
doaj   +1 more source

The mechanics of myeloid cells

Biology of the Cell, 2020
AbstractThe effects of cell size, shape and deformability on cellular function have long been a topic of interest. Recently, mechanical phenotyping technologies capable of analysing large numbers of cells in real time have become available. This has important implications for biology and medicine, especially haemato‐oncology and immunology, as immune ...
Mariana J. Kaplan, Kathleen R. Bashant, Kathleen R. Bashant, Nicole Toepfner, Christopher James Day, Jochen Guck, Edwin R. Chilvers, Charlotte Summers, Nehal N. Mehta   +8 more
openaire   +6 more sources

Acute myelogenous leukemia – current recommendations and approaches in molecular-genetic assessment

Romanian Journal of Internal Medicine, 2022
Acute myelogenous leukemia is a multi-step hematological malignancy, affecting function, growth, proliferation and cell cycle of myeloid precursors.
Yahya Dinnar, Hachmeriyan Mari, Micheva Ilina, Chervenkov Trifon   +3 more
doaj   +1 more source

Reliability of Cell-Free DNA and Targeted NGS in Predicting Chromosomal Abnormalities of Patients With Myeloid Neoplasms

Frontiers in Oncology, 2022
IntroductionCytogenetic analysis is important for stratifying patients with various neoplasms. We explored the use of targeted next generation sequencing (NGS) in detecting chromosomal structural abnormalities or copy number variations (CNVs) in patients
Andrew Ip, Andrew Ip, Andrew Ip, Alexandra Della Pia, Alexandra Della Pia, Gee Youn (Geeny) Kim, Gee Youn (Geeny) Kim, Jason Lofters, James Behrmann, Dylon Patel, Simone Kats, Jeffrey Justin Estella, Ivan De Dios, Wanlong Ma, Andrew L. Pecora, Andrew L. Pecora, Andrew L. Pecora, Andre H. Goy, Andre H. Goy, Andre H. Goy, Jamie Koprivnikar, Jamie Koprivnikar, James K. McCloskey, James K. McCloskey, Maher Albitar   +24 more
doaj   +1 more source

Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection

Frontiers in Immunology, 2019
Dendritic cells (DCs) play important roles in orchestrating host immunity against invading pathogens, representing one of the first responders to infection by mucosal invaders.
Jake William Rhodes, Jake William Rhodes, Orion Tong, Andrew Nicholas Harman, Andrew Nicholas Harman, Stuart Grant Turville, Stuart Grant Turville   +6 more
doaj   +1 more source

Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers

Haematologica, 2021
Cancer treatment is constantly evolving from a one-size-fits-all towards bespoke approaches for each patient. In certain solid cancers, including breast and lung, tumor genome profiling has been incorporated into therapeutic decision-making. For chronic
Vaidehi Krishnan, Dennis Dong Hwan Kim, Timothy P. Hughes, Susan Branford, S. Tiong Ong   +4 more
doaj   +1 more source

Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha

Frontiers in Physiology, 2018
The in vivo response to lipopolysaccharide (LPS) occurs rapidly and has profound physiological and metabolic effects. The hypoxia inducible (HIF) transcription factor is an intrinsic and essential part of inflammation, and is induced by LPS. To determine
Susan F. Fitzpatrick, Milos Gojkovic, David Macias, Tetyana Tegnebratt, Tetyana Tegnebratt, Li Lu, Li Lu, Erik Samén, Erik Samén, Helene Rundqvist, Randall S. Johnson, Randall S. Johnson   +11 more
doaj   +1 more source

Long-term experience in treatment of acute promyelocytic leukemia in Mexican children in a tertiary care hospital

Frontiers in Oncology, 2023
IntroductionAcute promyelocytic leukemia (APL) is a rare myeloid leukemia subtype affecting adult and pediatric populations. APL constitutes 15-20% of all childhood AML in Latin America, compared to 7% in the non-Latino population.
Marco Antonio Murillo-Maldonado, Paulina González Galván, Israel Parra Ortega, Félix Gaytán Morales, Félix Gaytán Morales, Luis Juárez Villegas, Elisa Dorantes Acosta, Elisa Dorantes Acosta   +7 more
doaj   +1 more source

Survival and predictors of mortality among acute leukemia patients on follow‐up in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A 5‐year retrospective cohort study

Cancer Reports, 2023
Background Although Ethiopia has more than 78% of leukemia cases and a significant burden of the disease, the survival of leukemia patients in the country is poorly recognized.
Bargude Balta, Tigistu Gebreyohannis, Erdaw Tachbele   +2 more
doaj   +1 more source