Results 51 to 60 of about 919,731 (432)
Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). [PDF]
, 2011 We report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia.
C Preudhomme +32 more
core +1 more source
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
New England Journal of Medicine, 2013 BACKGROUND Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear.
T. Ley +99 more
semanticscholar +1 more source
European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia
Leukemia, 2020 The therapeutic landscape of chronic myeloid leukemia (CML) has profoundly changed over the past 7 years. Most patients with chronic phase (CP) now have a normal life expectancy.
A. Hochhaus +33 more
semanticscholar +1 more source
Myeloid sarcoma in the tongue [PDF]
Autopsy and Case Reports, 2020 Leukemic cells are rarely present in the oral cavity, and there are very few reports regarding such cases. However, we identified some reports of leukemic cells infiltrating tissues in the oral cavity, including gingival involvement. Recurrent painful oral ulcerations and prominent generalized periodontal destruction are the most common oral features ...
Benites, Bernar Monteiro +5 more
openaire +4 more sources
American Journal of Perinatology Reports, 2021 Acute myeloid leukemia occurs rarely during pregnancy. When it is diagnosed remote from term, treatment in the form of daunorubicin plus cytarabine induction with consolidative cytarabine is typically undertaken after the first trimester. There is little
Christina M. Nowik +2 more
doaj +1 more source
Diagnosis of Acute Myeloid Leukaemia Using Machine Learning [PDF]
arXiv, 2021 We train a machine learning model on a dataset of 2177 individuals using as features 26 probe sets and their age in order to classify if someone has acute myeloid leukaemia or is healthy. The dataset is multicentric and consists of data from 27 organisations, 25 cities, 15 countries and 4 continents.
arxiv
Blood, 2009 Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology, published a revised and updated edition of the WHO Classification of Tumors of the Hematopoietic and ...
J. Vardiman +10 more
semanticscholar +1 more source
Induction in myeloid leukemic cells of genes that are expressed in different normal tissues [PDF]
PNAS 101, 16022 (2004), 2005 Using DNA microarray and cluster analysis of expressed genes in a cloned line (M1-t-p53) of myeloid leukemic cells, we have analyzed the expression of genes that are preferentially expressed in different normal tissues. Clustering of 547 highly expressed genes in these leukemic cells showed 38 genes preferentially expressed in normal hematopoietic ...
arxiv +1 more source
RNA editing signature during myeloid leukemia cell differentiation [PDF]
, 2017 Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis +48 more
core +2 more sources
New England Journal of Medicine, 2001 BACKGROUND BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine kinase activity is essential to the transforming function of BCR-ABL, an inhibitor of the kinase could be an effective treatment ...
B. Druker +10 more
semanticscholar +1 more source