Results 191 to 200 of about 382,920 (355)

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Plain language summary of a study on 30-minute intravenous infusion of isatuximab in people with newly diagnosed multiple myeloma. [PDF]

Future Oncol
Ocio EM, Perrot A, Moreau P, Mateos MV, Bringhen S, Martínez-López J, Karlin L, Oprea C, Li Y, Kodas E, San-Miguel J.   +10 more
europepmc   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma

New England Journal of Medicine, 2017
M. Attal, V. Lauwers-Cances, C. Hulin, X. Leleu, D. Caillot, M. Escoffre, B. Arnulf, M. Macro, K. Belhadj, L. Garderet, M. Roussel, C. Payen, C. Mathiot, J. Fermand, N. Meuleman, Sandrine Rollet, Michelle E. Maglio, Andrea A. Zeytoonjian, E. Weller, N. Munshi, K. Anderson, P. Richardson, T. Facon, H. Avet-Loiseau, J. Harousseau, P. Moreau   +25 more
semanticscholar   +1 more source

Multiple Myeloma Concomitant with AL Amyloidosis: Histopathological Aspects of the Common Plasma Cell Spectrum. [PDF]

Int J Mol Sci
Gioeva Z, Mikhaleva L, Tsutsaev A, Tebenkova A, Gutyrchik N, Shakhpazyan N, Ilyichev A, Kakturskij L.   +7 more
europepmc   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Retraction: Long Noncoding RNA CRNDE Promotes Multiple Myeloma Cell Growth by Suppressing miR-451. [PDF]

Oncol Res
Oncology Research Editorial Office.
europepmc   +1 more source

ALONG-TERM OBSERVATION OF A CASE OF BENCE JONES MYELOMA SHOWING AN INTERESTING PROLONGED COURSE, WITH A SPECIAL REFERENCE TO THE BIOLOGICAL BACKGROUND OF THE COURSE

, 1982
T Kanoh, Satoshi Hashimoto, Takashi Susawa, Yoshio Taniguchi, Haruto Uchino, Takamichi OKADA, Takashi Morita, SHOICHI HORII   +7 more
openalex   +2 more sources

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells [PDF]

, 2011
Dharminder Chauhan, Ze Tian, Bin Zhou, Deborah J. Kuhn, Robert Z. Orlowski, Noopur Raje, Paul Richardson, Kenneth C. Anderson   +7 more
openalex   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source