Results 111 to 120 of about 81,511 (306)

Effective Performance of the 2022 American College of Rheumatology/EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Pediatric Patients: An ARChiVe Study

Arthritis &Rheumatology, EarlyView.
Objective To assess the 2022 American College of Rheumatology (ACR)/EULAR classification criteria for antineutrophil cytoplasmic antibody–associated vasculitis (AAV) in children with chronic small‐to‐medium vessel vasculitis. Methods A cohort of 574 patients, identified by physician's diagnosis (MD‐diagnosis) in A Registry of Childhood Vasculitis, was ...
David A. Cabral, Else S. Bosman, Nick McPhate, Simranpreet K. Mann, Kirandeep K. Toor, Kimberly A. Morishita, Raashid Luqmani, Michael W. Beresford, James Bistolarides, Sarah Campillo, Sirirat Charuvanij, Kathryn Cook, Paul Dancey, Marietta de Guzman, Samundeeswari Deepak, Barbara Eberhard, Melissa Elder, Samuel Gagne, Katie Harrison, Adam Huber, Archana Khan, Susan Kim, Marisa S. Klein‐Gitelman, Tzielan C. Lee, Suzanne C. Li, Neil Martin, Flora McErlane, L. Nandini Moorthy, Alvaro H. Orjuela, Jonathan Park, Phil Riley, Alan M. Rosenberg, Susan Shenoi, Vidya Sivaraman, Sodality Sutnga, Tamara Tanner, Stacey E. Tarvin, Marinka Twilt, Linda Wagner‐Weiner, Rae S. M. Yeung, Kelly L. Brown, for the ARChiVe Investigators Network within the PedVas Initiative   +41 more
wiley   +1 more source

Glycoengineered Recombinant Alpha1‐Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma‐Derived Protein

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora, Chen‐Lin Hsieh, Sanne Schoffelen, Johnny Arnsdorf, Eric A. Toth, Abdul S. Yunus, Thomas E. Cleveland IV, Sara Petersen Bjørn, Mina Ying Min Wu, Noel G. McElvaney, Bjørn Gunnar Rude Voldborg, Thomas R. Fuerst, Nathan E. Lewis   +12 more
wiley   +1 more source

Effects of Aerobic Exercise on Leukocyte-Mediated Liver Destruction in a Rat Model of Metabolic Syndrome

Gazi Medical Journal
Objective: In this study, the levels of malondialdehyde (MDA), myeloperoxidase (MPO), and 3-nitrotyrosine (3-NT), which are known as oxidative/nitrosative stress markers, were investigated in the liver tissues of rats with metabolic syndrome model ...
Fatmanur Er, Leyla Çimen, Ceren Suveren, Canan Yılmaz, Nurten Türközkan   +4 more
doaj   +1 more source

Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer’s Disease

Frontiers in Neuroscience, 2019
Myeloperoxidase (MPO) is an enzyme expressed mostly by neutrophils and is a primary mediator of neutrophils oxidative stress response. While a profound body of evidence associates neutrophil-derived MPO in the pathogenesis of Alzheimer’s disease (AD ...
Rotem Volkman, Tali Ben-Zur, Anat Kahana, Ben Zion Garty, Daniel Offen, Daniel Offen   +5 more
doaj   +1 more source

Lung matrix metalloproteinase activity and myeloperoxidase content. [PDF]

, 2013
The effect of TOPO-PMAT QD administration on A) matrix metalloproteinase (MMP) activity and B) myeloperoxidase (MPO) content. Data represent the mean ± S.E.M.
Jianbo Yu (415571), Collin C. White (415568), Hui-Wen Wilkerson (415570), Russell Dills (415572), Xiaozhong Yu (415573), Federico M. Farin (128418), Dianne Botta (415567), Xiaohu Gao (415575), William C. Parks (261330), Terrance J. Kavanagh (216220), Lisa A. McConnachie (415566), Elaine M. Faustman (15108), Xiaoge Hu (415574), William C. Griffith (124045), Sean E. Gill (285197), Chad S. Weldy (415569), David L. Eaton (415576)   +16 more
core   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Immunomodulation of macrophage function by recombinant human myeloperoxidase [PDF]

, 1995
Regulation of the immune response is necessary for protection of the host as well as the avoidance of autoimmune diseases. The regulation of macrophage function by myeloperoxidase is a previously unrecognized function of this enzyme.
Castro, Aaron
core  

Myeloperoxidase activity and eNOS expression. [PDF]

, 2013
Median liver tissue myeloperoxidase (MPO) activity and endothelial NO synthase (e-NOS) expression at 120 min of reperfusion in all three groups (parentheses, interquartile range ...
George D. Tsoukalas (330684), Dimitrios Bakos (330669), Emmanuel E. Douzinas (330660), Marios-Konstantinos Tasoulis (330663), Ilias Andrianakis (330677), Olga Livaditi (330662), Nikolaos Goutas (330673), Panagiotis Prigouris (330666), Dimitrios Vlachodimitropoulos (37232), Alex Betrosian (330681)   +9 more
core   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency

Biomedical Papers, 2015
Aims: We sought to identify biochemical predictors that indicate susceptibility to in-stent restenosis (ISR) after coronary artery bare-metal stenting.
Leos Pleva, Pavlina Kusnierova, Pavlina Plevova, Jana Zapletalova, Michal Karpisek, Lucie Faldynova, Petra Kovarova, Pavel Kukla   +7 more
doaj   +1 more source