Results 91 to 100 of about 92,132 (290)

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Eugenol Inhibits Neutrophils Myeloperoxidase In Vitro and Attenuates LPS-Induced Lung Inflammation in Mice

Pharmaceuticals
Eugenol (Eug) is a polyphenol extracted from the essential oil of Syzygium aromaticum (L.) Merr. and Perry (Myrtaceae). The health benefits of eugenol in human diseases were proved in several studies.
Amina Chniguir, Mohamed Hedi Saguem, Pham My-Chan Dang, Jamel El-Benna, Rafik Bachoual   +4 more
doaj   +1 more source

Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells

, 2014
Background: Upon activation neutrophil releases microparticles - small plasma membrane vesicles that contain cell surface proteins and cytoplasmic matter, with biological activities.
Rocha, Viviane Costa Junqueira, Alberto Augusto Noronha-Dutra, Pontes-de-Carvalho, Lain Carlos, Pitanga, Thassila Nogueira, Dutra, Alberto Augusto Noronha, Washington Luis Conrado dos-Santos, Marilda Souza Gonçalves, Thassila Pitanga, Gonçalves, Marilda de Souza, Valéria Matos Borges, dosSantos, Washington Luis Conrado, Thassila Nogueira Pitanga, Lain Pontes-de-Carvalho, Washington Luis dos-Santos, Meirelles, Thayna, Viviane Costa Junqueira Rocha, Lain Carlos Pontes-de-Carvalho, Alberto Noronha-Dutra, Viviane Costa Rocha, Luciana de Aragão França, Thayna Meirelles, Borges, Valeria de Matos, Marilda Gonçalves, França, Luciana Souza de Aragão   +23 more
core   +1 more source

Recent Advances in High‐Entropy Nanozymes: From Fabrication to Applications

Advanced Science, EarlyView.
To highlight key achievements and clarify the current landscape of high‐entropy nanozymes (HEAzymes), this review summarizes state‐of‐the‐art developments ranging from thermodynamically and kinetically controlled synthetic strategies; enzyme‐like catalytic types, catalytic characteristics, and underlying mechanisms; to their antioxidative, therapeutic,
Yongjian Ai, Weibo Zhang, Pengjie Wang, Wentao Xu, Huiyuan Guo, Hong‐bin Sun, Meng‐Qi He, Fazheng Ren, Qionglin Liang   +8 more
wiley   +1 more source

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal

Journal of Lipid Research, 2010
Neutrophils are important in the host response against invading pathogens. One chemical defense mechanism employed by neutrophils involves the production of myeloperoxidase (MPO)-derived HOCl.
Dhanalakshmi S. Anbukumar, Laurie P. Shornick, Carolyn J. Albert, Melissa M. Steward, Raphael A. Zoeller, William L. Neumann, David A. Ford   +6 more
doaj   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Estradiol as an antioxidant: incompatible with its physiological concentrations and function

Journal of Lipid Research, 1998
Estradiol has been documented to inhibit the oxidation of low density lipoprotein (LDL). We show that physiological concentrations of estradiol do not inhibit the oxidation of LDL by copper.
Nalini Santanam, Robin Shern-Brewer, Ruth McClatchey, Penny Z. Castellano, Ana A. Murphy, Steve Voelkel, Sampath Parthasarathy   +6 more
doaj   +1 more source

Myeloperoxidase-Sensitive T₁ and T₂ Switchable MR Imaging for Diagnosis of Nonalcoholic Steatohepatitis

, 2023
Nonalcoholic steatohepatitis (NASH) is the critical stage in the development of nonalcoholic fatty liver disease (NAFLD) from simple and reversible steatosis to irreversible cirrhosis and even hepatocellular carcinoma (HCC).
Hui Jun Ting (14602980), Bin Liu (5899), Yuanbo Wang (1345647), Jiong-Wei Wang (2182460), Jingjing Liu (305549), Xiaoyuan Wang (492534), Xiaodong Yu (2322238), Shidang Xu (2871020), Sitong Zhang (11466911)   +8 more
core   +1 more source