Results 101 to 110 of about 87,247 (298)

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Effects of Aerobic Exercise on Leukocyte-Mediated Liver Destruction in a Rat Model of Metabolic Syndrome

Gazi Medical Journal
Objective: In this study, the levels of malondialdehyde (MDA), myeloperoxidase (MPO), and 3-nitrotyrosine (3-NT), which are known as oxidative/nitrosative stress markers, were investigated in the liver tissues of rats with metabolic syndrome model ...
Fatmanur Er, Leyla Çimen, Ceren Suveren, Canan Yılmaz, Nurten Türközkan   +4 more
doaj   +1 more source

Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer’s Disease

Frontiers in Neuroscience, 2019
Myeloperoxidase (MPO) is an enzyme expressed mostly by neutrophils and is a primary mediator of neutrophils oxidative stress response. While a profound body of evidence associates neutrophil-derived MPO in the pathogenesis of Alzheimer’s disease (AD ...
Rotem Volkman, Tali Ben-Zur, Anat Kahana, Ben Zion Garty, Daniel Offen, Daniel Offen   +5 more
doaj   +1 more source

Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke

, 2017
Primary intracerebral haemorrhage and lacunar ischaemic stroke are acute manifestations of progressive cerebral microvascular disease. Current paradigms suggest atherosclerosis is a chronic, dynamic, inflammatory condition precipitated in response to ...
Slowik, Agnieszka, Roquer, Jaume, Goldstein, Joshua N., Greenberg, Steven M, Jonathan Rosand, Steven J Kittner, Słowik, Agnieszka, Mitchell, Braxton D., Björn M Hansen, Worrall, Brad B, Hansen, Björn M, Enzinger, Christian, Anand Viswanathan, Markus, Hugh S, Jagiella, Jeremiasz M, Phuah, Chia-Ling, Chia-Ling Phuah, Steven M Greenberg, Alexander Pichler, Jordi Jimenez-Conde, Fernandez-Cadenas, Israel, Rainer Malik, Joshua N Goldstein, Raffeld, Miriam R., Langefeld, Carl D, Jagiella, Jeremiasz M., Rosand, Jonathan, Jeremiasz M Jagiella, Agnieszka Slowik, Israel Fernandez-Cadenas, Martin Dichgans, Bo Norrving, Jagiełła, Jeremiasz, null null, Reinhold Schmidt, Markus, Hugh S., Natalia Rost, Alessandro Biffi, Biffi, Alessandro, Carl D Langefeld, Ayres, Alison M., Mitchell, Braxton D, Norrving, Bo, Christian Enzinger, Greenberg, Steven M., Dave, Tushar, Joan Montaner, Langefeld, Carl D., Kittner, Steven J, Alison M Ayres, Christopher D Anderson, Ayres, Alison M, Jimenez-Conde, Jordi, Anderson, Christopher D., Tushar Dave, Lindgren, Arne, Arne Lindgren, Woo, Daniel, Hugh S Markus, Fernandez- Cadenas, Israel, Montaner, Joan, Kittner, Steven J., Jaume Roquer, Viswanathan, Anand, Daniel Woo, Hansen, Björn M., Schmidt, Reinhold, Dichgans, Martin, Malik, Rainer, Braxton D Mitchell, Rost, Natalia, Raffeld, Miriam R, Worrall, Brad B., Brad B Worrall, Pichler, Alexander, Anderson, Christopher D, Miriam R Raffeld, Goldstein, Joshua N   +77 more
core   +1 more source

Some patients with anti-myeloperoxidase autoantibodies have a C-ANCA pattern

, 1994
Rapidly progressive glomerulonephritis with or without other signs of systemic vasculitis is often accompanied by antibodies to myeloperoxidase. Such antibodies normally produce a perinuclear pattern on ethanol-fixed neutrophils (perinuclear anti ...
B BASLUND, M SEGELMARK, Segelmark, M., J WIESLANDER, Baslund, B., Wieslander, J.   +5 more
core   +2 more sources

Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency

Biomedical Papers, 2015
Aims: We sought to identify biochemical predictors that indicate susceptibility to in-stent restenosis (ISR) after coronary artery bare-metal stenting.
Leos Pleva, Pavlina Kusnierova, Pavlina Plevova, Jana Zapletalova, Michal Karpisek, Lucie Faldynova, Petra Kovarova, Pavel Kukla   +7 more
doaj   +1 more source

Association of Tumor Necrosis Factor-α and Neutrophilic Inflammation in Severe Asthma

Allergology International, 2005
Background: There is evidence that neutrophils are increased in the airway of severe disease or acute exacerbations of asthma. The mechanisms by which neutrophils are recruited to the airways and contribute to the pathophysiology of asthma remain to be ...
Shinya Kikuchi, Izumi Kikuchi, Koichi Hagiwara, Minora Kanazawa, Makoto Nagata   +4 more
doaj   +1 more source

Myeloperoxidase-induced fibrinogen unfolding and clotting

Due to its unique properties and high biomedical relevance fibrinogen is a promising protein for the development of various matrixes and scaffolds for biotechnological applications.
Matveeva A.G., Klinov D.V., Moskalets A.P., Dubrovin E.V., Tolstova A.P., Barinov N.A., Pavlova E.R.   +6 more
core   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source