Results 81 to 90 of about 92,132 (290)

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source

Anti-myeloperoxidase autoantibodies react with native but not denatured myeloperoxidase

Clinical and Experimental Immunology, 1992
SUMMARY We wondered whether anti-myeloperoxidase (MPO) autoantibodies (MPO-ANCA) found in patients with systemic vasculitis react with a conformational epitope or epitopes on the MPO molecule. Sera from 15 human MPO-ANCA, and a polyclonal and a monoclonal anti-MPO antibodies were reacted with MPO in native and denatured states. Human MPO-
R J, Falk, M, Becker, R, Terrell, J C, Jennette   +3 more
openaire   +3 more sources

Targeting pepsin provides superior protection to acid suppression in reflux-associated airway inflammation and lung dysfunction. [PDF]

Exp Physiol
Abstract Gastro‐oesophageal reflux disease is a prevalent condition associated with extra‐oesophageal manifestations, such as pulmonary inflammation. Pepsin, an essential gastric enzyme, has been implicated in pulmonary complications owing to its inflammatory effects.
Sales TMAL, da Costa Filho HB, Gadelha KKL, Nogueira KM, Franco ÁX, Monteiro CEDS, de Sousa MKA, Souza MC, Melo ISS, Nicolau LAD, Clementino MAF, Magalhães PJC, Havt A, Soares PMG, Sifrim D, de Souza MHLP.   +15 more
europepmc   +2 more sources

Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish [PDF]

, 2012
Prompt neutrophil arrival is critical for host defense immediately after injury [1-3]. Following wounding, a hydrogen peroxide (H(2)O(2)) burst generated in injured tissues is the earliest known leukocyte chemoattractant [4]. Generating this tissue-scale
Pase, L., C J Nowell (13377531), Renshaw, S. A., J K Heath (16144118), Keightley, M Cristina, Crosier, P. S., Ellett, Felix, Grabher, C., Nowell, C. J., Lieschke, G. J., Heath, J. K., Nowell, Cameron J, L Pase (16144055), G J Lieschke (16144058), Layton, J. E., Reyes-Aldasoro, C. C., S A Renshaw (16144061), Pase, Luke, C J Hall (16144106), Layton, Judith E, Varma, S., Rogers, Kelly L, C Wittmann (16144097), J E Layton (16144094), Hall, C. J., C C Reyes Aldasoro (16089011), C Grabher (16144115), F Ellett (16144100), Lieschke, Graham J, K L Rogers (16144103), Wittmann, Christine, P S Crosier (16144112), Keightley, M. C., Varma, Sony, S Varma (7797932), M C Keightley (16144109), Renshaw, Stephen A, Wittmann, C., Rogers, K. L., Grabher, Clemens, Ellett, F., Heath, Joan K, Hall, Chris J, Crosier, Philip S, Reyes-Aldasoro, Constantino Carlos   +44 more
core   +1 more source

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source

Low serum myeloperoxidase in autistic children with gastrointestinal disease

, 2009
Anthony J Russo1, Arthur Krigsman2, Bryan Jepson2, Andy Wakefield21Research Director, Health Research Institute/Pfeiffer Treatment Center, Warrenville, IL, USA; 2Thoughtful House Center for Children, Austin, TX, USAAim: To assess serum myeloperoxidase ...
Arthur Krigsman, et al, Anthony J Russo, Bryan Jepson   +3 more
core  

Reactions of Superoxide with Myeloperoxidase^†

, 2016
When neutrophils ingest bacteria, they discharge superoxide and myeloperoxidase into phagosomes. Both are essential for killing of the phagocytosed micro-organisms.
Anthony J. Kettle (2403607), Mark B. Hampton (359087), Robert F. Anderson (1311654), Christine C. Winterbourn (2258608)   +3 more
core   +1 more source

Anti-myeloperoxidase antibodies stimulate neutrophils to damage human endothelial cells [PDF]

, 1992
Anti-myeloperoxidase antibodies stimulate neutrophils to damage human endothelial cells. Anti-myeloperoxidase autoantibodies are found in association with idiopathic necrotizing glomerulonephritis and systemic vasculitis.
Jennette, J. Charles, Falk, Ronald J., Ewert, Brian H., Ewert, Brian, Falk, Ronald   +4 more
core   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source

Myeloperoxidase and Inflammatory Bowel Disease

, 2020
Examining the relationship of neutrophil extracellular traps (NETs) in clinical IBD samples and the role of myeloperoxidase in modulating the gut ...
Chami, Belal
core