Results 61 to 70 of about 87,247 (298)

Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling

, 2017
Rationale: Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial ischemia. Myeloperoxidase, a heme enzyme released by polymorphonuclear neutrophils, accumulates within ischemic myocardium and has been linked to ...
Florian G. Deuschl, Hazen, Stanley L., Rudolph, Tanja K., Klinke, Anna, Kerkenpa, Christina, Gabriel Peinkofer, Mehrkens, Dennis, Dennis Mehrkens, Maass, Martina, Adam, Matti, Tang, W.H. Wilson, Volker Rudolph, Saric, Tomo, Wu, Yuping, Jan Gesenberg, Manchanda, Kashish, Anna Klinke, Lau, Denise, Johanna Schneider, Kai Friedrichs, Schneider, Johanna, Tomo Saric, Peinkofer, Gabriel, Stephan Baldus, Martin Mollenhauer, Deuschl, Florian G., Thomas Eschenhagen, Lisa Remane, W.H. Wilson Tang, Ravekes, Thorben, Martina Maass, Denise Lau, Tanja K. Rudolph, Eschenhagen, Thomas, Mollenhauer, Martin, Marcel Halbach, Kubala, Lukas, Matti Adam, Halbach, Marcel, Remane, Lisa, Jenny Krause, Rudolph, Volker, Christina Kerkenpaß, Lukas Kubala, Friedrichs, Kai, Thorben Ravekes, Krause, Jenny, Yuping Wu, Lange, Max, Baldus, Stephan, Stanley L. Hazen, Max Lange, Geertz, Birgit, Gesenberg, Jan, Birgit Geertz, Kashish Manchanda   +55 more
core   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Myeloperoxidase in human intracranial aneurysms: preliminary evidence

, 2015
BACKGROUND AND PURPOSE: Noninvasive imaging identifying a predictive biomarker of the bleeding risk of unruptured intracranial aneurysms (UIAs) is needed. We investigated a potential biomarker of UIA instability, myeloperoxidase, in human aneurysm tissue.
Vedantham, Srinivasan, Brooks, Christopher S., Bogdanov, Alexei A. Jr., Weaver, John P., Puri, Ajit S, Gounis, Matthew J, Wakhloo, Ajay K.   +6 more
core   +1 more source

Nanoparticle effect on neutrophil produced myeloperoxidase [PDF]

, 2018
Nanoparticles affect the immune system as they may interact directly with immune cells and activate them. However, it is possible that nanoparticles also interact with released cytokines and immunologically active enzymes.
Manuel Vilanova, Elodie Sanfins, Gunnarsson, Stefan B., Stefan B Gunnarsson, Alexandra Correia, Tommy Cedervall, Cedervall, Tommy, Correia, Alexandra, Vilanova, Manuel, Stefan B. Gunnarsson, Sanfins, Elodie   +10 more
core   +2 more sources

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Short‐Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundShort‐term exposure to elevated air pollution has been associated with higher risk of acute cardiovascular diseases, with systemic oxidative stress induced by air pollution hypothesized as an important underlying mechanism.
Wenyuan Li, Elissa H. Wilker, Kirsten S. Dorans, Mary B. Rice, Joel Schwartz, Brent A. Coull, Petros Koutrakis, Diane R. Gold, John F. Keaney, Honghuang Lin, Ramachandran S. Vasan, Emelia J. Benjamin, Murray A. Mittleman   +12 more
doaj   +1 more source

Myeloperoxidase and Lysozymes as a Pivotal Hallmark of Immunity Status in Rabbits

Animals, 2020
Infectious diseases, due to their massive scale, are the greatest pain for all rabbit breeders. Viral infections cause enormous economic losses in farms. Treating sick rabbits is very difficult and expensive, so it is very important to prevent disease by
Rafał Hrynkiewicz, Dominika Bębnowska, Paulina Niedźwiedzka-Rystwej   +2 more
doaj   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Identification of glutathione adducts of α-chlorofatty aldehydes produced in activated neutrophils

Journal of Lipid Research, 2015
α-Chlorofatty aldehydes (α-ClFALDs) are produced by hypochlorous acid targeting plasmalogens during neutrophil activation. This study investigated the reaction of the α-chlorinated carbon of α-ClFALD with the nucleophile, GSH.
Mark A. Duerr, Rajeev Aurora, David A. Ford   +2 more
doaj   +1 more source

Eosinophils and Neutrophils—Molecular Differences Revealed by Spontaneous Raman, CARS and Fluorescence Microscopy

Cells, 2020
Leukocytes are a part of the immune system that plays an important role in the host’s defense against viral, bacterial, and fungal infections. Among the human leukocytes, two granulocytes, neutrophils (Ne) and eosinophils (EOS) play an important role in ...
Aleksandra Dorosz, Marek Grosicki, Jakub Dybas, Ewelina Matuszyk, Marko Rodewald, Tobias Meyer, Jürgen Popp, Kamilla Malek, Malgorzata Baranska   +8 more
doaj   +1 more source