Results 31 to 40 of about 119,702 (326)
Journal of International Clinical Dental Research Organization, 2021 Background: Smoking is the second strongest modifiable risk factor for periodontal disease. Tissue destruction might result from matrix metalloproteinase (MMP)/tissue inhibitors of MMP (TIMP) imbalance in the diseased tissues.
Deepti Gattani +3 more
doaj +1 more source
Hereditary myeloperoxidase deficiency [PDF]
Blood, 1981 Subjects with neutrophil myeloperoxidase (MPO) deficiency have been rarely reported. In part this may be due to the lack of a simple screening technique that would detect them. With the routine use of a cytochemical leukocyte differential counter that employs MPO stains, over a 40-mo a period 8 unrelated probands with partial MPO-deficiency and one ...
M, Kitahara +4 more
openaire +3 more sources
Antioxidants, 2019 The immunological response in bacterial meningitis (BM) causes the formation of reactive oxygen and nitrogen species (ROS, RNS) and activates myeloperoxidase (MPO), an inflammatory enzyme. Thus, structural oxidative and nitrosative damage to proteins and
Emilie Rugemalira +9 more
doaj +1 more source
Frontiers in Immunology, 2021 BackgroundAllergic contact dermatitis (ACD) is a common skin disorder affecting an estimated 15-20% of the general population. The mouse model of ACD is contact hypersensitivity (CHS), which consists of two phases: induction and elicitation.
Anna Strzepa +7 more
doaj +1 more source
Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease [PDF]
, 2017 open4siAging is the biggest risk factor for developing many neurodegenerative disorders, including idiopathic Parkinson's disease (PD). PD is still an incurable disorder and the available medications are mainly directed to the treatment of symptoms in ...
core +1 more source
Myeloperoxidase G-463A and CYBA C242T genetic variants in gestational diabetes mellitus
Vascular Biology, 2023 Oxidative stress plays an important role in the pathophysiology of gestational diabetes mellitus (GDM). We investigated the relationship between NADPH oxidase p22phox subunit (CYBA) C242T (rs4673) and myeloperoxidase (MPO) G-463A (rs2333227) genetic ...
Chenyu Jiang +10 more
doaj +1 more source
Genome-Wide Association with Select Biomarker Traits in the Framingham Heart Study [PDF]
, 2007 BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes.
Benjamin, Emelia J. +18 more
core +3 more sources
Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]
, 2011 p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Arthur, J. Simon C. +6 more
core +3 more sources
The Iraqi Journal of Veterinary Medicine, 2022 This study aimed to investigate the potential protective role of Bifidobacterium (B.) infantis in alleviating induced duodenal and colon inflammation associated with ulcerative colitis (UC).
Majida Al-Qayim +3 more
doaj +1 more source
A combined clinical and biomarker approach to predict diuretic response in acute heart failure [PDF]
, 2015 Background: Poor diuretic response in acute heart failure is related to poor clinical outcome. The underlying mechanisms and pathophysiology behind diuretic resistance are incompletely understood.
Bloomfield, Daniel M. +16 more
core +4 more sources