Results 91 to 100 of about 18,051 (238)

Heavy and light roles: myosin in the morphogenesis of the heart [PDF]

, 2012
Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies suggest that both myosin heavy-chain ...
A Abu-Daya, A Du, A Horowitz, A Houmeida, A Wessels, AA Lagrutta, AE Chambers, AN Tullio, AS Warkman, AV Postma, B Brenner, BA Danowski, BG Bruneau, BN Davis, BR Cullen, BS Budde, BS Pan, BV Latinkic, C Gove, C Huang, C Rutland, C Wang, CR Bagshaw, CS Rutland, CT Basson, D Franco, D Franco, D Hailstones, D Jin, D Linde van der, D Maughan, D Mornet, D Rhee, D Yelon, DJ Timson, DM Alvarado, DO Fürst, E Berdougo, E Carniel, E Eisenberg, E Flashman, E Rooij van, E Rooij van, EM Small, EP Kirk, F Charron, G Bonne, GE Lyons, H Huxley, H Niimura, H Pannu, H Suzuki, H Wada, HJ Auman, HJ Li, HL Sweeney, HM Warrick, I Morano, I Morano, I Rayment, J Chen, J Fewell, J Flavigny, J Gulick, J Stull, JD Molkentin, Jennifer England, JGF Cleland, JJ Schott, JM Miano, JP Sluijter, JS Davis, JS Park, JT Granados-Riveron, JY Chan, K Imanaka-Yoshida, K Poetter, K Takeda, K Trybus, KD Wilson, KK Turnacioglu, KM Price, KN Ivey, KT Tokuyasu, L Khait, L Zhu, L Zhu, LD Sacks, LM Auckland, M Arad, M Chandra, M Goujon, M Maitra, M Morano, M Xin, MA Geeves, MA Larkin, MC Schaub, MG Posch, MJ Macera, ML Bell, MS Parmacek, N Liu, ND Epstein, ND Moncrief, O Ogut, O Ritter, P Andersen, P Richard, P VanBuren, P Vibert, PFM Ven Van Der, PJ Barton, PJ Barton, PJ Reiser, PS Andersen, Q Shi, QY Li, R Nishigaki, R Walsh, RE Cheney, RE Hershberger, RJ Garriock, RL Moss, RM Toydemir, S Ghatpande, S Goswami, S Lu, S Machida, S Somi, Siobhan Loughna, SJ Smith, SS Lehrer, SW Kubalak, T Boettger, T Takaya, TE Callis, TM Olson, TQP Uyeda, TX O’Brien, V Garg, VJ Ferrans, W Barillot, W Dillmann, W Lehman, W Lu, W Rottbauer, W-H Lee, WF Harrington, WF Harrington, WK Jones, WL Fodor, X Ma, X Ma, Y Hiroi, Y Ishikawa, Y Nakajima, Y Taneda, Y Yang, YH Ching, Z Chen, Z Wang, ZT Kabaeva, ZZ Bao   +163 more
core   +3 more sources

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]

, 2020
Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo, Bruno Mirra, Cristina Mazzaccara, Ferdinando Barretta, Giulia Frisso, Olga Scudiero   +5 more
core   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Homozygous Pro1066Arg MYBPC3 Pathogenic Variant in a 26Mb Region of Homozygosity Associated with Severe Hypertrophic Cardiomyopathy in a Patient of an Apparent Non-Consanguineous Family

Life, 2022
MYPBC3 and MYH7 are the most frequently mutated genes in patients with hereditary HCM. Homozygous and compound heterozygous genotypes generate the most severe phenotypes.
Raquel Rodríguez-López, Javier García-Planells, Marina Martínez-Matilla, Cristian Pérez-García, Amor García Banacloy, Carola Guzmán Luján, Otilia Zomeño Alcalá, Joaquina Belchi Navarro, Juan Martínez-León, Rafael Salguero-Bodes   +9 more
doaj   +1 more source

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network [PDF]

, 2019
Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their
Alessio, Enrico, Bertoli, Alessandro, Buson, Lisa, Cagnin, Stefano, Chemello, Francesco, Grespi, Francesca, Lanfranchi, Gerolamo, Martini, Paolo, Massimino, Maria L, Millino, Caterina, Pacchioni, Beniamina, Peggion, Caterina, Romualdi, Chiara, Scorrano, Luca   +13 more
core   +1 more source

A MYH7 variant in a five-generation-family with hypertrophic cardiomyopathy

Frontiers in Genetics
Background: Hypertrophic cardiomyopathy (HCM) is a genetic condition with a prevalence of 1:500–1:3 000. Variants in genes encoding sarcomeric proteins are mainly responsible for the disease.
M. Franke, Tomasz M Książczyk, Marta Dux, P. Chmielewski, G. Truszkowska, Dorota Czapczak, R. Pietrzak, Z. Bilińska, Urszula Demkow, Bożena Werner   +9 more
semanticscholar   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, EarlyView.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

The structural effects of mutations can aid in differential phenotype prediction of beta-myosin heavy chain (Myosin-7) missense variants [PDF]

, 2016
MOTIVATION: High-throughput sequencing platforms are increasingly used to screen patients with genetic disease for pathogenic mutations, but prediction of the effects of mutations remains challenging.
Al-Numair, NS, Elliott, P, Lopes, L, Martin, AC, Monserrat, L, Syrris, P   +5 more
core   +1 more source