Results 81 to 90 of about 18,051 (238)

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Identification of enhancers responsible for the coordinated expression of myosin heavy chain isoforms in skeletal muscle

BMC Genomics, 2022
Background Skeletal muscles consist of fibers of differing contractility and metabolic properties, which are primarily determined by the content of myosin heavy chain (MYH) isoforms (MYH7, MYH2, MYH1, and MYH4).
Keren Long, Duo Su, Xiaokai Li, Hengkuan Li, Sha Zeng, Yu Zhang, Zhining Zhong, Yu Lin, Xuemin Li, Lu Lu, Long Jin, Jideng Ma, Qianzi Tang, Mingzhou Li   +13 more
doaj   +1 more source

Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy [PDF]

, 2010
BACKGROUND: Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and a proposed substrate for arrhythmias and heart failure. In animal models, profibrotic genetic pathways are activated early, before hypertrophic remodeling.
Cirino, A.L. (Alison L.), Coelho-Filho, O.R. (Otavio R.), Colan, S.D. (Steven D.), Diez-Martinez, J. (Javier), Gonzalez, A. (Arantxa), Ho, C.Y. (Carolyn Y.), Jarolim, P. (Petr), Kwong, R.Y. (Raymond Y.), Lakdawala, N.K. (Neal K.), Lopez-Salazar, M.B. (María Begoña), Seidman, C.E. (Christine E.), Seidman, J.G. (J.G.)   +11 more
core   +1 more source

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine, EarlyView.
This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
wiley   +1 more source

Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy. [PDF]

, 2014
BACKGROUND: Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH).
Bassett, P, Bluemke, DA, Canter, CE, Captur, G, Day, SM, Elliott, PM, Esteban, MT, Ferreira, VM, Finocchiaro, G, Ho, CY, Li, C, Lopes, LR, McKenna, WJ, Mohun, TJ, Moon, JC, Muthurangu, V, Patel, V, Seidman, CE, Sherrid, MV   +18 more
core   +1 more source

Studying Pathogenetic Contribution of a Variant of Unknown Significance, p.M659I (c.1977G > A) in MYH7, to the Development of Hypertrophic Cardiomyopathy Using CRISPR/Cas9-Engineered Isogenic Induced Pluripotent Stem Cells

International Journal of Molecular Sciences
Hypertrophic cardiomyopathy (HCM) is a cardiovascular pathology that is caused by variants in genes encoding sarcomere-associated proteins. However, the clinical significance of numerous variants in HCM-associated genes is still unknown. CRISPR/Cas9 is a
S. Pavlova, A. E. Shulgina, S. Zakian, E. V. Dementyeva   +3 more
semanticscholar   +1 more source

A Splice Variant of the MYH7 Gene Is Causative in a Family with Isolated Left Ventricular Noncompaction Cardiomyopathy

Genes, 2022
Variants of the MYH7 gene have been associated with a number of primary cardiac conditions, including left ventricular noncompaction cardiomyopathy (LVNC).
R. Myasnikov, O. Kulikova, A. Meshkov, A. Bukaeva, A. Kiseleva, A. Ershova, A. Petukhova, M. Divashuk, E. Zotova, E. Sotnikova, Alexandra Abisheva, Alisa Muraveva, S. Koretskiy, Sergey V. Popov, Marina Utkina, E. A. Snigir, S. Mitrofanov, K. D. Konureeva, Elena Mershina, V. Sinitsyn, S. M. Yudin, O. Drapkina   +21 more
semanticscholar   +1 more source

Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation

Advanced NanoBiomed Research, EarlyView.
This review provides an overview of stimulation strategies used to enhance the functional maturation of bioprinted excitable tissues. It addresses key limitations in physiological performance of bioprinted excitable tissues, outlines major stimulation modalities—including electrical, mechanical, optical, magnetic, ultrasound, and hybrid—and examines ...
Uijung Yong, Jinseon Park, Jinah Jang
wiley   +1 more source

Generation of induced pluripotent stem cells (iPSCs) from a hypertrophic cardiomyopathy patient with the pathogenic variant p.Val698Ala in beta-myosin heavy chain (MYH7) gene

Stem Cell Research, 2017
Induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) isolated from the whole blood of a 43-year-old male with hypertrophic cardiomyopathy (HCM) who carries the pathogenic variant p.Val698Ala in beta-myosin
Samantha Barratt Ross, Stuart T. Fraser, Natalie Nowak, Christopher Semsarian   +3 more
doaj   +1 more source

Left ventricular noncompaction associated with a pathogenic mutation in the MYH7 gene: Known mutation, different phenotype

Revista Portuguesa de Cardiologia, 2022
Left ventricular noncompaction (LVNC) is a genetically heterogeneous cardiomyopathy, with familial and sporadic forms, but genetic testing only identifies a pathogenic mutation in a minority of cases.
Margarida Oliveira, Olga Azevedo, Bebiana Faria, Pedro von Hafe, Geraldo Dias, Ricardo Faria, Victor Sanfins, Mário Lourenço, Gabriel Miltenberger-Miltenyi, António Lourenço   +9 more
doaj   +1 more source