Results 171 to 180 of about 34,760 (297)

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo   +3 more
wiley   +1 more source

Myocardial Perfusion Defects in Hypertrophic Cardiomyopathy Mutation Carriers

open access: yesJournal of the American Heart Association, EarlyView., 2021
Background Impaired myocardial blood flow (MBF) in the absence of epicardial coronary disease is a feature of hypertrophic cardiomyopathy (HCM). Although most evident in hypertrophied or scarred segments, reduced MBF can occur in apparently normal segments.
Rebecca K. Hughes   +14 more
wiley   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

open access: yesVIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang   +6 more
wiley   +1 more source

Hemocompatibility Outcomes After Aspirin Withdrawal in Long‐Term HeartMate 3 Left Ventricular Assist Device Patients on Vitamin K Antagonists

open access: yesArtificial Organs, EarlyView.
Aspirin discontinuation in long‐term, stable Heart Mate 3 LVAD patients maintained on Vitamin K antagonists did not increase hemocompatibility‐related adverse events. These findings support the safety of simplified antithrombotic therapy and extend randomized evidence for aspirin avoidance to the long‐term management of Heart Mate 3 recipients ...
Melanie Arnreiter   +8 more
wiley   +1 more source

Fundamental Anatomy and Its Impact on Clinical Practice: Myocardial Bridging. [PDF]

open access: yesJACC Case Rep
Ortega-Pérez R   +3 more
europepmc   +1 more source

Hospital Costs Associated With Mechanical Left Ventricular Unloading Devices During VA ECMO for Adult Cardiogenic Shock

open access: yesArtificial Organs, EarlyView.
In a cohort of patients with cardiogenic shock supported with V‐A ECMO, the addition of left ventricular mechanical unloading was associated with higher median hospitalization costs ($390 508 vs. $320 269), longer hospital length of stay (IRR 1.06, p < 0.001), and lower mortality compared with VA ECMO alone (HR 0.62, p = 0.006).
Maxwell A. Hockstein   +7 more
wiley   +1 more source

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