Results 191 to 200 of about 34,760 (297)

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

open access: yesThe FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto   +9 more
wiley   +1 more source

Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat

open access: yesThe FEBS Journal, EarlyView.
Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory   +3 more
wiley   +1 more source

Real‐World Use of Emicizumab in Patients With Acquired Haemophilia A: An Interim Safety Analysis of a Large‐Scale Post‑Marketing Surveillance Study

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction Acquired haemophilia A (AHA) is a rare autoimmune disorder where the development of autoantibodies to factor (F)VIII neutralise its function, leading to bleeding. Emicizumab has been approved for treating AHA in Japan. Aim This post‐marketing study was performed to primarily examine the use and safety of emicizumab, and indirectly
Midori Shima   +8 more
wiley   +1 more source

Prognostic Value of Small Coved‐Type ST‐Segment Area in Patients With Spontaneous Type 1 Brugada Syndrome

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
Electrical and structural abnormalities in Brugada syndrome lead to a smaller coved‐type ST‐segment area. A reduced ST‐segment area may identify patients at elevated risk of ventricular fibrillation. ABSTRACT Background Risk stratification in Brugada syndrome (BrS) remains challenging.
Nario Sano   +10 more
wiley   +1 more source

From gateway to value ladder—The curious case of online mutual aid in China

open access: yesJournal of Risk and Insurance, EarlyView.
Abstract This study examines how InsurTech‐enabled information provision, specifically the disclosure of claimant information previously unavailable in conventional insurance, influences individuals' insurance uptake. We leverage Mutual Aid (MA) platforms as a natural context to examine how socially framed loss information, peer influence, and salience
Ze Chen   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy