Results 21 to 30 of about 88,408 (209)

Effects of Short Term Adiponectin Receptor Agonism on Cardiac Function and Energetics in Diabetic db/db Mice

Journal of Lipid and Atherosclerosis, 2022
Objective Impaired cardiac efficiency is a hallmark of diabetic cardiomyopathy in models of type 2 diabetes. Adiponectin receptor 1 (AdipoR1) deficiency impairs cardiac efficiency in non-diabetic mice, suggesting that hypoadiponectinemia in type 2 ...
Aleksandre Tarkhnishvili, Christoph Koentges, Katharina Pfeil, Johannes Gollmer, Nikole J Byrne, Ivan Vosko, Julia Lueg, Laura Vogelbacher, Stephan Birkle, Sibai Tang, Timothy Bon-Nawul Mwinyella, Michael M Hoffmann, Katja E Odening, Nathaly Anto Michel, Dennis Wolf, Peter Stachon, Ingo Hilgendorf, Markus Wallner, Senka Ljubojevic-Holzer, Dirk von Lewinski, Peter Rainer, Simon Sedej, Harald Sourij, Christoph Bode, Andreas Zirlik, Heiko Bugger   +25 more
doaj   +1 more source

Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction

JACC: Basic to Translational Science, 2023
Summary: Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at
Sanjiv Kaul, MD, Carmen Methner, PhD, Zhiping Cao, PhD, Anusha Mishra, PhD   +3 more
doaj   +1 more source

Modulation of Myocardial Contraction by Peroxynitrite

Frontiers in Physiology, 2012
Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on ...
Mark eKohr, Steve eRoof, Jay eZweier, Mark T Ziolo   +3 more
doaj   +1 more source

Strain bidimensional na cardiopatia de Takotsubo Two-dimensional strain in Takotsubo cardiomyopathy

Arquivos Brasileiros de Cardiologia, 2010
Este relato apresenta o seguimento tardio de um caso de cardiomiopatia de Takotsubo com boa evolução clínica e melhora da função sistólica global ventricular esquerda.
Carlos Bellini G. Gomes, Gustavo J. Veras   +1 more
doaj   +1 more source

The ezrin Gene Regulates Early Cardiac Morphogenesis and Contractile Function in Zebrafish Through the Coordinated Regulation of Apoptosis, Calcium Homeostasis, and the MAPK Signaling Pathway

Cells
Ezrin, expressed by the EZR gene, is a member of the ERM protein family that connects the plasma membrane to the actin cytoskeleton, participating in processes such as cell adhesion, migration, and signaling.
Jinrui Lv, Ting Zeng, Beiya Liao, Ling Liu, Lei Xiong, Hao Xie, Lin Zhu, Xingzi Jiang, Zhuchuyu Zhong, Huaping Xie   +9 more
doaj   +1 more source

Effects of sugammadex and rocuronium on electro-mechanical activity of cardiac myocytes [PDF]

Korean Journal of Anesthesiology
Background Sugammadex reverses the effects of steroidal neuromuscular-blocking agents, such as rocuronium, by encapsulating these agents. Its cardiovascular adverse effects include QTc prolongation, hypotension, bradycardia, atrioventricular block ...
Oguzhan Arun, Nihal Ozturk, Orhan Erkan, Semir Ozdemir, Funda Arun, Sırma Basak Yanardag, Murat Ayaz   +6 more
doaj   +1 more source

Effect of αα₂-adrenoceptor stimulation on the isolated rat heart after acute myocardial infarction

КардиоСоматика
Background: α2-Adrenoceptors (α2-ARs) are a family of G protein–coupled receptors. They are located on presynaptic membranes of adrenergic fibers, postsynaptic membranes of cardiomyocytes and vascular smooth muscle cells, as well as in the peripheral and
Anna M. Kuptsova, Nafisa I. Ziyatdinova, Aiziriak M. Sadykov, Timur L. Zefirov   +3 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source