Results 51 to 60 of about 68,210 (242)

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

open access: yesAdvanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng   +9 more
wiley   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

open access: yesAdvanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng   +7 more
wiley   +1 more source

Biodegradable Medical Implants: Reshaping Future Medical Practice

open access: yesAdvanced Science, EarlyView.
Biodegradable medical implants are transforming future healthcare by providing sustainable, biocompatible solutions that eliminate secondary removal procedures, enhancing patients’ physical and psychological comfort, and reducing economic burdens.
Bo Xia   +4 more
wiley   +1 more source

Polyphenol‐Based Functional Materials: Structural Insights, Composite Strategies, and Biomedical Applications

open access: yesAdvanced Science, EarlyView.
This schematic representation illustrates the interaction mechanisms between polyphenolic compounds and various materials (metals, proteins, polysaccharides, alkaloids, etc.). And explains the potential clinical application value of these materials (nanoparticles, coatings, films, capsules, and hydrogels constructed using polyphenols) in the fields of ...
Songwen Xue   +6 more
wiley   +1 more source

Myocardial Oxygen Consumption as Influenced by Isotonic Contractions.

open access: yesExperimental Biology and Medicine, 1962
SummaryOxygen consumption of non-stimulated trabeculae carneae, which were maintained at various resting tensions, was not increased when they were stimulated to contract isotonically at a frequency of one per second. The data further indicate that the aerobic metabolism of heart muscle was uninfluenced by resting tensions comparable to those in vivo.
openaire   +3 more sources

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
This review provides an intriguing review of the recent advancements, challenges, and future perspectives regarding the application of piezoelectric scaffolds in tissue regeneration. The detailed exposition is anticipated to propel the advancement of personalized and intelligent piezoelectric implants, thereby fostering significant progress in this ...
Xiaoling Deng   +7 more
wiley   +1 more source

Smart Textile Systems for Loneliness Monitoring in Older People Care: A Review of Sensing and Design Innovations

open access: yesAdvanced Electronic Materials, EarlyView.
This review explores the potential of smart textile systems for monitoring loneliness in older adults. It presents key behavioral and physiological indicators of loneliness and evaluates recent sensing and design innovations in smart textile technology. The study identifies challenges and outlines opportunities for developing user‐centered, comfortable
Yi Zhou   +12 more
wiley   +1 more source

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