Results 101 to 110 of about 696,855 (303)

An appraisal of the histopathological assessment of liver fibrosis [PDF]

, 2006
One of the most important aspects of the histopathological assessment of liver biopsies in the setting of chronic liver disease is determination of the degree of fibrosis and architectural change.
Dhillon, A.P., Cholongitas, E., Dhillon, A., Burroughs, A.K., Standish, R.A.   +4 more
core  

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Ayuko Takahashi (789901), Barbara D. Smith (2212672), Takahashi, A, Christopher Denton, Layne, MD, Bahja Ahmed-Abdi, Ayuko Takahashi, Suki, B, Nikitorowicz-Buniak, J, Bela Suki (2212681), Bahja Ahmed-Abdi (2212675), Matthew D. Layne (364786), Markella Ponticos, Ahmed-Abdi, B, Robert Lafyatis, Markella Ponticos (2212669), Xu Shiwen (2212678), Stratton, R, Bela Suki, Barbara D Smith, Richard Stratton (776213), Joanna Nikitorowicz-Buniak (776212), Smith, BD, Christopher Denton (276245), Xu Shiwen, Lafyatis, R, David Abraham (36404), Shiwen, X, David Abraham, Abraham, D, Matthew D Layne, Ponticos, M, Denton, C, Joanna Nikitorowicz-Buniak, Robert Lafyatis (38139), Richard Stratton   +35 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Deciphering myocardial fibrosis: a comprehensive bibliometric analysis of mechanism over the period 1992–2023

Journal of Cardiothoracic Surgery
Background Myocardial fibrosis is a critical link in preventing the progression of heart disease. This study conducted a bibliometric analysis of its mechanism to identify trends and hotspots, aiming to provide valuable references for heart disease ...
Jiaojiao Zhang, Wenhui Wang, Zhen Wang, Meiqi Zhou, Shengbing Wu   +4 more
doaj   +1 more source

Mitophagy as a therapeutic target for myocardial fibrosis: Mechanistic insights and potential pharmacological interventions

Pakistan Journal of Pharmaceutical Sciences
Myocardial fibrosis is a central pathological feature of various cardiovascular diseases, including heart failure and hypertension. It involves the activation of cardiac fibroblasts, transforming them into myofibroblasts that secrete pro-fibrotic factors,
Jie Wu, Tingjuan Mei, Yang Dong, Fen Zhang, Xingxing Li, Lei Wang   +5 more
doaj   +1 more source

The effect of pre-treatment with Troxerutin on myocardial fibrosis in rats with doxorubicin-induced cardiotoxicity [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. Doxorubicin (DOX) is a highly effective anthracycline drug widely used in cancer treatment. Myocardial fibrosis, a key pathological consequence of DOX-induced cardiotoxicity, impairs cardiac function and increases the risk of heart failure ...
Babaei-Kouchaki - Sara, Badalzadeh Reza, Vahab Babapour, Panahi Negar, Ahmad Jamei Khosroshahi   +4 more
doaj   +1 more source

Myocardial fibrosis in heart failure

, 2017
Heart failure is a major contributor to mortality and morbidity, both in Australia and worldwide. Despite significant recent therapeutic advances, many patients ultimately progress to advanced cardiomyopathy.
Iles, Leah Maree (3796102)
core   +1 more source

Myocardial tissue characterization and fibrosis by imaging [PDF]

, 2019
Myocardial fibrosis, either focal or diffuse, is a common feature of many cardiac diseases and is associated with a poor prognosis for major adverse cardiovascular events.
Karamitsos, Theodoros D, Arvanitaki, Alexandra, Neubauer, Stefan, Karvounis, Haralambos, Ferreira, Vanessa M   +4 more
core   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source