Results 91 to 100 of about 299,715 (311)

Ketone body metabolism activates the immune response against Staphylococcus aureus infection by fueling the tricarboxylic acid cycle and affecting histone β-hydroxybutyrylation

Cell Insight
Staphylococcus aureus (S. aureus) is a prominent human pathogen that causes persistent inflammation and is notoriously difficult to treat. Fasting is one of host adaptations to infection, and the induction of ketogenesis and ketolysis is a well-described
Huanhuan Cai, Xin Yue, Yingbo Chen, Xiaoyu Chen, Renbo Qiao, Gechang Zhong, Shuo Rong, Lin Zhang, Zelong Li, Aihua Liao, Wei Xiong, Cihang Guo, Yanfang Zhu, Keqiong Deng, Li Zhou, Ying Zhu, Zhibing Lu, Xiangtai Zeng, Shi Liu   +18 more
doaj   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm

, 2006
Background: Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury.
MacAllister, R.J., Loukogeorgakis, S.P., Panagiotido, A.T., Yellon, D.M., Deanfield, J.E.   +4 more
core  

Studies on the role of inflammation and stem cells in cardiac ischaemic injury [PDF]

, 2008
The regenerative capacity of human myocardium is unable to compensate adequately forth significant loss of heart muscle that occurs in acute myocardial infarction (Ml).
Ahmed, Ishtiaq M., Ahmed, Ishtiaq M
core  

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study [PDF]

, 2010
Background: The aetiology and clinical significance of troponin release following endurance exercise is unclear but may be due to transient myocardial inflammation.
Wong Joyce, Whyte, G, Prasad, SK, Whyte, Greg, Smith Gillian, Annette Dahl, Smith, Gillian, Wage, R, Godfrey, R, Wilson, M, Gillian Smith, Francisco D Alpendurada, Sharma Sanjay, Prasad, Sanjay, O'Hanlon Rory, George Keith, Wage, Riccardo, Pennell, DJ, Pennell Dudley J, Roughton, Michael, Prasad Sanjay K, Roughton Michael, George, Keith, Rory O'Hanlon, Alpendurada Francisco D, Mat Wilson, Pennell, Dudley, Roughton, M, Sharma, S, Dahl, Annette, Greg Whyte, Sanjay K Prasad, Wilson Mat, Dave Oxborough, Alpendurada, Francisco, O'Hanlon, Rory, Keith George, Oxborough, Dave, Godfrey Richard, Wage Riccardo, Wong, Joyce, Dahl, A, Whyte Greg, Wilson, Mat, Smith, G, Joyce Wong, Richard Godfrey, Sanjay Sharma, Wong, J, Alpendurada, FD, Oxborough, D, Oxborough Dave, O'Hanlon, R, Dudley J Pennell, Riccardo Wage, Godfrey, Richard, Sharma, Sanjay, Michael Roughton, Dahl Annette, George, K   +59 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress

, 2019
Changlei Guo, Junbiao Zhang, Peiyong Zhang, Aoyang Si, Zhenling Zhang, Liangping Zhao, Fenghua Lv, Guoan Zhao Department of Cardiology, The First Affiliated Hospital Xinxiang Medical University, Weihui 452100, Henan, China Purpose: Ginkgolide B (GB) is
Si A, Zhao L, Lv F, Zhang J, Zhang Z, Zhao G, Guo C, Zhang P   +7 more
core