Results 181 to 190 of about 107,803 (293)

Ablation of Slc26a6 Mitigates Myocardial Ischemia/Reperfusion Injury. [PDF]

Biomedicines
Thai PN, Ren L, Diloretto DA, Trinh P, Timofeyev V, Zong N, Ngo RQ, Chiamvimonvat N, Zhang XD.   +8 more
europepmc   +1 more source

Mitoxyperilysis: A Novel Cell Death Pathway With Transformative Implications for Organ Pathophysiology and Therapeutic Innovation

Organ Medicine, EarlyView.
Wenhao Shen, Junmei Li, Weifeng Hu
wiley   +1 more source

Inflammatory Cytokines as Early Predictors of Weaning Failure From Extracorporeal Life Support

Artificial Organs, EarlyView.
Levels of IL‐8 and IL‐6 and their dynamics are reliable early predictors of ECLS weaning failure. ABSTRACT Background Weaning from extracorporeal life support (ECLS) in patients with refractory shock still remains a complex decision. Despite considerable advances in ECLS management, reliable biomarkers to predict weaning success are still not available.
Kostiantyn Kozakov, Alois Philipp, Maik Foltan, Anton Heller, Dzmitry Turtsevich, Christian Schach, Peter‐Paul Ellmauer, Walter Petermichl, Bernhard Flörchinger, Christof Schmid, Simon Schopka, Zdenek Provaznik   +11 more
wiley   +1 more source

Engineered neutrophil membrane nanosystem for targeted siRNA therapy in myocardial ischemia-reperfusion injury. [PDF]

J Nanobiotechnology
Jiang Y, Wang Z, Chen P, Lu H, Tian X, Jiang P, Luo R, Zhou Y, Lv Z, Mao W, Ren S, Wang X, Sang H, Yang W.   +13 more
europepmc   +1 more source

Outcomes in Patients Requiring VENO‐Venous Extracorporeal Membrane Oxygenation After Cardiac Surgery: An Analysis From the PELS‐1 Study

Artificial Organs, EarlyView.
We report an insight from the PELS‐1– a multicentre, international registry focusing on postocardiotomy extracorporeal support use between 2000 and 2020. We focused on 24/2163 (1.1%) patients requiring V‐V ECMO after cardiac surgery. Mortality was high, with 21.7% of patients discharged alive and an overall 1‐year survival probability of 12.5 ...
Pasquale Nardelli, Silvia Mariani, Maria Elena De Piero, Bas C. T. van Bussel, Michele Di Mauro, Ann‐Kristin Schaefer, Diyar Saeed, Matteo Pozzi, Luca Botta, Udo Boeken, Robertas Samalavicius, Karl Bounader, Xiaotong Hou, Jeroen J. H. Bunge, Hergen Buscher, Leonardo Salazar, Bart Meyns, Michael A. Mazzeffi, Marco L. Sacha Matteucci, Sandro Sponga, Kollengode Ramanathan, Claudio Russo, Francesco Formica, Pranya Sakiyalak, Antonio Fiore, Daniele Camboni, Giuseppe Maria Raffa, Rodrigo Diaz, I‐wen Wang, Jae‐Seung Jung, Jan Belohlavek, Vin Pellegrino, Giacomo Bianchi, Matteo Pettinari, Alessandro Barbone, José P. Garcia, Kiran Shekar, Glenn Whitman, Roberto Lorusso, PELS Investigators   +39 more
wiley   +1 more source

The treatment of myocardial ischemia-reperfusion injury: potential roles of natural drug modulating CaMKII. [PDF]

Front Pharmacol
Yang K, Zhang P, Hui X, Liu C, Li J, Liu Y.   +5 more
europepmc   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

BAK and BAX: Therapeutic Targets for Acute Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury. [PDF]

Biology (Basel)
Xu Z, Meng F, Yang H, Liu Y, Ye K, Qin F, Liu D, Dai H.   +7 more
europepmc   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source