Results 201 to 210 of about 107,803 (293)

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

Lysosomal homeostasis regulates myocardial ischemia-reperfusion injury through autophagy pathway. [PDF]

Sci Rep
Li Y, Liu Y, Wu H, Zhang S, Liu D, Huang X, Zhou G, Zhang D, Yang X, Zhou T, Xiong Y.   +10 more
europepmc   +1 more source

Myocardial and Neural Damage due to Pulmonary Vein Isolation: Comparison of Pulsed Electric Field and Thermal Ablation

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Pulmonary vein isolation (PVI) using thermal energy—radiofrequency (RF) or cryoablation (CRYO)—is associated with direct myocardial injury and collateral neural damage. In contrast, pulsed electric field (PEF) energy has emerged as a neural‐sparing alternative.
Predrag Stojadinović, Nicoletta Ventrella, Hana Alfredová, Vanda Filová, Dan Wichterle, Petr Peichl, Robert Čihák, Eva Borišincová, Petr Štiavnický, Jana Hašková, Janka Franeková, Bashar Aldhoon, Josef Kautzner   +12 more
wiley   +1 more source

Lactate regulates the YTHDF2-FTH1 axis to promote cardiomyocyte ferroptosis and aggravate myocardial ischemia-reperfusion injury. [PDF]

Sci Rep
Xiang Z, Xiang B, Ouyang T, Long Y, Zhang C.   +4 more
europepmc   +1 more source

Systolic‐dominant coronary flow in rats and mice: Challenging the diastolic paradigm across conscious and anaesthetized states

Experimental Physiology, EarlyView.
Abstract Extensive research in humans, dogs, rabbits, rats, mice and other mammals has consistently demonstrated that coronary blood flow (CBF) peaks during ventricular diastole. For example, studies using transthoracic Doppler echocardiography in anaesthetized rats and mice, isolated blood‐perfused rat hearts and Doppler probes sutured to the ...
Heidi L. Lujan, Theodore W. Kurtz, Stephen E. DiCarlo   +2 more
wiley   +1 more source

Establishment of a mouse model for ischaemic heart failure induced by coronary microembolization via left ventricular oil injection

Experimental Physiology, EarlyView.
Abstract Over the past three decades, there has been a steady increase in clinical attention to ischaemic heart failure caused by coronary microembolization. Nonetheless, a suitable mouse model for studying this condition remains limited. In the present study, we developed a mouse model of coronary microembolization‐induced ischaemic heart failure by ...
Lang Pei, Yusheng Hong, Qiuyue Wu, Jianyi Lv, Changlong Li, Xueyun Huo, Xin Liu, Di Zhang, Meng Guo, Zhenwen Chen, Xiaoyan Du   +10 more
wiley   +1 more source

The effect of TIM1⁺ Breg cells in myocardial ischemia-reperfusion injury. [PDF]

Cell Death Discov
Zeng C, Qi J, Wu F, Yang W, Kong M, Cheng H, Dong A, Han J, Chen W, Chen D, Duan Q.   +10 more
europepmc   +1 more source

Identification of Pyroptosis-Related Genes and Immune Landscape in Myocardial Ischemia-Reperfusion Injury. [PDF]

Biomedicines
Zhu Y, Zhu H, Zhou J, Wu J, Hu X, Li C, Cai H, Lu Z.   +7 more
europepmc   +1 more source

Cardioprotection via vagus nerve stimulation preconditioning: Reducing ischaemia–reperfusion injury and arrhythmic risk

Experimental Physiology, EarlyView.
Abstract Acute myocardial infarction is a leading cause of morbidity and mortality, with ischaemia–reperfusion (I/R) injury exacerbating myocardial damage. Vagus nerve stimulation (VNS) has been reported to exert cardioprotective effects, but its efficacy in preconditioning against I/R injury requires further investigation.
Feng Hu, Yali Wang, Guangyu Li, Guangyu Wang, Qi Zhuang, Jinyao Jiang, Danfeng Hu, Lihui Zheng, Yan Yao, Minhua Zang, Jun Pu   +10 more
wiley   +1 more source

Advanced Nanomaterial Platforms for Targeted Therapy of Myocardial Ischemia-Reperfusion Injury. [PDF]

Research (Wash D C)
Wang H, Li L, Luo L, Cheng Y, Zhou F, Zhao S, Li Y, Yang Y, Zhou Q, Niu H, He J, Zhang C, Guo J, Tang L, Xu J.   +14 more
europepmc   +1 more source