Results 221 to 230 of about 107,803 (293)

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Lipoxin A4 improves myocardial ischemia/reperfusion injury through the Notch1-Nrf2 signaling pathway. [PDF]

Open Life Sci
Yan X, Chen A, Gong Y, Xu J, Lu J, Wang L, Fan Y, Gao N, Zhou L, Cao H, Kuang X.   +10 more
europepmc   +1 more source

Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis

Food Frontiers, Volume 7, Issue 2, March 2026.
The diagram of the mechanism of action by which UroA regulates RF. ABSTRACT The global prevalence and mortality rates associated with chronic kidney disease (CKD) have been on a continuous rise over recent decades. Renal fibrosis (RF) serves as a critical factor in the progression of CKD to end‐stage renal disease.
Xue Wu, Jiating Li, Yonghui Dong, Jia Li, Ji Bian, Chao Liu, Hongbo Zhang, Lin Han, Min Wang   +8 more
wiley   +1 more source

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia-Reperfusion Injury. [PDF]

MedComm (2020)
Li Z, Jiang F, Chen Y, Li Z, Wu Y, He Z, Wu D, Xiang H.   +7 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Myocardial Ischemia/Reperfusion Injury: Molecular Insights, Forensic Perspectives, and Therapeutic Horizons. [PDF]

Cells
Fede MS, Daziani G, Tavoletta F, Montana A, Compagnucci P, Goteri G, Neri M, Busardò FP.   +7 more
europepmc   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

<i>CACNB1</i> alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation. [PDF]

Mol Med Rep
Shao Q, Zhang J, Wang H.
europepmc   +1 more source

Real Time Evaluation of Whole Organ Perfusion by Magnetic Resonance Imaging in Ex Vivo Machine‐Perfused Liver

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
Porcine livers underwent mechanical perfusion inside an MRI scanner, enabling dynamic quantitative measurements of whole organ perfusion. Vascular segmentation down to 0.45 mm resolution allowed quantification of morphological features such as vessel tortuosity, while Dynamic Contrast Enhanced MRI and diffusion weighted imaging was used to produce ...
Zainab L. Rai, Natalie A. Holroyd, Morenike Magbagbeola, Emre Doganay, Katie Doyle, Lucy Caselton, Agostino Stilli, Danail Stoyanov, Simon Walker‐Samuel, Brian R. Davidson   +9 more
wiley   +1 more source

Melatonin inhibits ferroptosis in myocardial ischemia/reperfusion injury by inhibiting the ATM/p53 signaling pathway. [PDF]

Redox Rep
Wang P, Wang D, Lv Z, Zhang P, Su X, Zhao T, Dong Y, Li S.   +7 more
europepmc   +1 more source