Results 271 to 280 of about 106,495 (306)

Clarithromycin attenuates myocardial ischemia–reperfusion injury

Expert Opinion on Therapeutic Targets, 2010
MMP activity is upregulated in the heart after myocardial ischemia reperfusion, and its activation contributes to the changes in left ventricular (LV) dysfunction. A major macrolide antibiotic, clarithromycin has many biological functions including MMP regulation.
Takuya, Nakajima, Keiichi, Hishikari, Masahito, Ogawa, Ryo, Watanabe, Jun-ichi, Suzuki, Ayako, Nagashima, Mayumi, Masumura, Kiyoshi, Takayama, Yasunobu, Hirata, Ryozo, Nagai, Mitsuaki, Isobe   +10 more
openaire   +2 more sources

The Protective of Baicalin on Myocardial Ischemia-Reperfusion Injury

Current Pharmaceutical Biotechnology, 2020
Background:The aim of this study was to explore the inhibitory effect of baicalin on myocardial apoptosis induced by Ischemia-Reperfusion (I/R).Methods:Sprague Dawley rats' heart and myocardial cells I/R model were established in vivo and vitro, then 100 mg/kg and 10 μmol/l baicalin were administrated, respectively.
Xiaoli Liu, Shanshan Zhang, Chaoyue Xu, Yongchao Sun, Shujian Sui, Zhaohua Zhang, Yun Luan   +6 more
openaire   +2 more sources

Complement inhibitors in myocardial ischemia/reperfusion injury

Immunopharmacology, 1997
Myocardial ischemia/reperfusion injury is accompanied by an inflammatory response contributing to reversible and irreversible changes in tissue viability and organ function. Endothelial and leukocyte responses are involved in tissue injury, orchestrated primarily by the complement cascade.
B R, Lucchesi, K S, Kilgore
openaire   +2 more sources

Perioperative myocardial ischemia reperfusion injury

Anesthesiology Clinics of North America, 2003
Myocardial I-R injury contributes to adverse cardiovascular outcomes after cardiac surgery. The pathogenesis of I-R injury is complex and involves the activation, coordination, and amplification of several systemic and local proinflammatory pathways (Fig. 4).
openaire   +2 more sources

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Journal of Visualized Experiments, 2022
Acute myocardial infarction is a common cardiovascular disease with high mortality. Myocardial reperfusion injury can counteract the beneficial effects of heart reflow and induce secondary myocardial injury. A simple and reproducible model of myocardial infarction and myocardial ischemia-reperfusion injury is a good tool for researchers.
Bingjie, Lv, Jin, Zhou, Shaolin, He, Yuqi, Zheng, Wenlin, Yang, Shangwei, Liu, Chengxing, Liu, Boyuan, Wang, Dazhu, Li, Jibin, Lin   +9 more
openaire   +2 more sources

C5aR-mediated myocardial ischemia/reperfusion injury

Biochemical and Biophysical Research Communications, 2007
The complement system activation can mediate myocardial ischemia and reperfusion (I/R). Inhibition of C5a activity reveals attenuation of I/R-induced myocardial infarct size. However, the contribution of C5a receptor (C5aR) to I/R injury remains to be unknown.
Haimou, Zhang, Gangjian, Qin, Gang, Liang, Jinan, Li, Robert A, Barrington, Dong-Xu, Liu   +5 more
openaire   +2 more sources

Progress in Therapies for Myocardial Ischemia Reperfusion Injury

Current Drug Targets, 2017
Experimental studies of acute myocardial infarction have revealed that up to half of the final infarct size may be due to reperfusion injury rather than the initial ischemic incident. Research over the past three decades has deepened our understanding of the molecular mechanisms underlying ischemic reperfusion injury and several therapeutic strategies ...
Hong-Jie, Chi, Mu-Lei, Chen, Xin-Chun, Yang, Xiang-Min, Lin, Hao, Sun, Wen-Shu, Zhao, Dan, Qi, Jia-Lu, Dong, Jun, Cai   +8 more
openaire   +2 more sources

A Murine Model of Myocardial Ischemia–Reperfusion Injury

2018
Ligation of the left anterior descending (LAD) coronary artery in the mouse heart is a widely used model to simulate myocardial infarction and ischemia-reperfusion injury. Here we describe a ligation technique routinely performed in our laboratory to induce myocardial infarction that may be used to study ischemia-reperfusion injury in the myocardium ...
Zhaobin, Xu, Kevin E, McElhanon, Eric X, Beck, Noah, Weisleder   +3 more
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Effects of tramadol on myocardial ischemia-reperfusion injury

Scandinavian Cardiovascular Journal, 2007
The aim of the present study was to evaluate the effect of tramadol on isolated rat hearts subjected to global ischemia-reperfusion injury.Langerdorff perfused isolated rat hearts were subjected to 60 min of global ischemia following 60 min of reperfusion. In group I and III hearts were received tramadol before the onset of ischemia.
Bilir, Ayten, Erkasap, Nilufer, Koken, Tulay, Gulec, Sacit, Kaygisiz, Ziya, Tanriverdi, Belkis, Kurt, Imran   +6 more
openaire   +2 more sources

Antioxidants in the prevention of myocardial ischemia/reperfusion injury

Expert Review of Clinical Pharmacology, 2009
In acute myocardial ischemia (AMI) the optimal treatment is rapid revascularization by angioplasty or pharmacological thrombolysis. While this is essential to resuscitate the ischemic myocardium, it results in further reperfusion injury and extension of the infarction.
Chengxue, Qin, Suwan, Yap, Owen L, Woodman   +2 more
openaire   +2 more sources