Results 51 to 60 of about 129,108 (303)

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study from the EUSTAR Cohort

Arthritis Care &Research, Accepted Article.
Objective JAK inhibitors (JAKis) have shown promising effects in early‐phase studies of SSc. We aimed to assess the safety and explore effectiveness of JAKis compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the EUSTAR cohort was performed.
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P Denton, Madelon C Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Análise comparativa da reserva de glicogénio do miocardio isquémico de coelhos submetidos a cardioplegia hipotérmica ou normotérmica Comparative analysis of ischemic myocardium glycogen reserve of rabbits submitted to hypothermic or normothermic cardioplegia

Brazilian Journal of Cardiovascular Surgery, 1992
Neste trabalho, a comparação da reserva de glicogênio é utilizada para entender as modificações na sensibilidade mitocondrial ao íon cálcio. Basicamente porque alterações mitocondriais que envolvam perda da atividade de fosforilação oxidativa
Clovis Carbone Jr, José E. S Roselino, Joáo J Carneiro, Albert A Sader   +3 more
doaj  

Bilateral remote ischemic conditioning in children: A two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgeryCentral MessagePerspective

JTCVS Open
Objective: The study objective was to determine whether adequately delivered bilateral remote ischemic preconditioning is cardioprotective in young children undergoing surgery for 2 common congenital heart defects with or without cyanosis.
Nigel E. Drury, PhD, FRCS(CTh), Carin van Doorn, MD, FRCS(CTh), Rebecca L. Woolley, MSc, Rebecca J. Amos-Hirst, MSc, Rehana Bi, BSc(Hons), Collette M. Spencer, BSc(Hons), Kevin P. Morris, MD, FRCPCH, James Montgomerie, MD, FRCA, John Stickley, BSc, Adrian Crucean, MD, Alicia Gill, MSc, Matt Hill, MSc, Ralf J.M. Weber, PhD, Lukas Najdekr, PhD, Andris Jankevics, PhD, Andrew D. Southam, PhD, Gavin R. Lloyd, PhD, Osama Jaber, MD, Imre Kassai, PhD, Giuseppe Pelella, MD, Natasha E. Khan, MD, FRCS(CTh), Phil Botha, PhD, FRCS(CTh), David J. Barron, MD, FRCS(CTh), Melanie Madhani, PhD, Warwick B. Dunn, PhD, Natalie J. Ives, MSc, Paulus Kirchhof, MD, Timothy J. Jones, MD, FRCS(CTh), Edmund D. Carver, Alistair J. Cranston, Fraser Harban, Vasco Laginha Rolo, Ritchie Marcus, Anthony Moriarty, Raju Reddy, Susanna N. Ritchie-McLean, Monica A. Stokes, Ayngara Thillaivasan, Nandlal Bhatia, Carol Bodlani, Wendy Lim, Joe Mellor, Jutta Scheffczik   +42 more
doaj   +1 more source

Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury [PDF]

, 2010
HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated sphingophospholipids have similar effects.
Bodo Levkau, Levkau, Bodo, Herrgott, Ilka, Johanning, Kai, Echtermeyer, Frank, Chun, Jerold, Hildebrand, Reinhard, Ilka Herrgott, Gregor Theilmeier, Christine Herzog, Winterhalter, Michael, Frank Ulrich Müller, Schmitz, Martina, Müller, Frank Ulrich, Jan Mersmann, Michael Winterhalter, Reinhard Hildebrand, Martina Schmitz, Herzog, Christine, Frank Echtermeyer, Jerold Chun, Theilmeier, Gregor, Mersmann, Jan, Larmann, Jan, Jan Larmann, Kai Johanning   +25 more
core   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Revascularização miocárdica de urgência após complicação de angioplastia transluminal coronária: abordagem cirúrgica atual Emergency myocardial revascularization after complicated percutaneous transluminal coronary angioplasty: actual surgical approach

Brazilian Journal of Cardiovascular Surgery, 1990
Entre julho de 1981 e fevereiro de 1990, foram realizados no INCOR 3016 angioplastias transluminais coronárias (ATC), em 2431 pacientes portadores de insuficiência coronária em suas diferentes manifestações. A cirurgia de revascularizaçâo do miocárdio de
Luís Alberto Dallan, Sérgio de Almeida Oliveira, Hedy Cecchy, Siguemituso Ariê, Alexandre Sabino Neto, José Carlos R Iglézias, Geraldo Verginelli, Adib D Jatene   +7 more
doaj  

Hibiscus syriacus L. Exhibits Cardioprotective Activity via Anti-Inflammatory and Antioxidant Mechanisms in an In Vitro Model of Heart Failure

Life
Hibiscus syriacus L. (HS), native to Eastern and Southern Asia, has been traditionally used in Asian herbal medicine for its anticancer, antimicrobial, and anti-inflammatory properties.
Hung-Hsin Chao, Tzu-Hurng Cheng, Chun-Chao Chen, Ju-Chi Liu, Jin-Jer Chen, Li-Chin Sung   +5 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Engineering Strain‐Stiffening Granular Hydrogels for 3D‐Printed Tissue‐Mimicry

Advanced Materials, EarlyView.
A 3D‐printable strain‐stiffening double‐network granular hydrogel (SDGH) enables independent, region‐specific tuning of toe (EToe) and heel (EHeel) moduli through control of microgel packing and network composition. This platform replicates tissue‐like nonlinear mechanics and allows fabrication of high‐fidelity, multilayered aortic valves with ...
Hyeokju Chae, Joohwan Han, Jeong‐Wook Seo, Taehoon Lee, Kihyeon Bae, Yeontaek Lee, Dong Soo Kim, Ikjin Kim, Jin‐Oh Kim, Steve Park   +9 more
wiley   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source