Results 181 to 190 of about 105,760 (306)

Ischemia-Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions. [PDF]

MedComm (2020)
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
An P, An Y, Chen M, Wu L, Wang R.
europepmc   +2 more sources

Evaluating high‐sensitivity troponin levels in people with sickle cell disease in the emergency department

British Journal of Haematology, EarlyView.
This study shows that sickle cell disease patients have elevated high‐sensitivity cardiac troponin I (hs‐cTnI) that is not considered clinically significant but are outside of the normal range. Elevated hs‐cTnI was associated with low haemoglobin and a history of heart failure.
Abdelrhman Mohammed, Najibah A. Galadanci, Gerhard Hellemann, Julie Kanter   +3 more
wiley   +1 more source

Iron Deficiency Is Associated With Impaired Myocardial Reperfusion in ST-Segment-Elevation Myocardial Infarction: Influence of the Definition Used. [PDF]

J Am Heart Assoc
Barrabés JA, Inserte J, Castellote L, Buera I, Milà L, Sambola A, Uribarri A, Vidal M, Aluja D, Delgado-Tomás S, Tobías-Castillo PE, Calvo-Barceló M, Guala A, Rodríguez-Palomares JF, Del Blanco BG, Beneítez D, Ferreira-González I.   +16 more
europepmc   +1 more source

Aging-associated Alteration in the Cardiac MIF-AMPK Cascade in Response to Ischemic Stress

, 2008
An important role for a macrophage migration inhibitory factor (MIF)-AMP-activated protein kinase (AMPK) signaling pathway in ameliorating myocardial damage following ischemia/reperfusion has been described. An aging-associated reduction in AMPK activity
Lin Leng, Richard Bucala, Erin Lane, Heng Ma, Jingying Wang, Jun Ren, Wenkui Wang, Ji Li   +7 more
core  

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Identification of splenic IRF7 as a nanotherapy target for tele-conditioning myocardial reperfusion injury. [PDF]

Nat Commun
Long Q, Rabi K, Cai Y, Li L, Huang S, Qian B, Zhong Y, Qi Z, Zhang Y, Huang K, Wang X, Chang L, Xie W, Jiang H, Zhang H, Zhang J, Ren T, Wang Z, Teesalu T, Wu C, Lu L, Zhu Z, Chu Y, Santos HA, Liu Z, Zhao Q, Ye X.   +26 more
europepmc   +1 more source

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

Mitochondrial transplantation combined with mitoquinone and melatonin: A survival strategy against myocardial reperfusion injury in aged rats. [PDF]

Exp Physiol
Mokhtari B, Delkhah M, Badalzadeh R, Ghaffari S.   +3 more
europepmc   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Enhanced recovery in type A aortic dissection evaluating the efficacy and feasibility of early myocardial reperfusion. [PDF]

Front Cardiovasc Med
Niu T, Liu Z, Liu Y, Yang Z, Ge Y, Wang L, Xia L, Jiang H.   +7 more
europepmc   +1 more source