Results 71 to 80 of about 100,863 (292)

Role of cardiac renin angiotensin system in ischemia reperfusion injury and preconditioning of heart

Indian Heart Journal, 2016
Cardio-vascular diseases are the leading cause of morbidity and mortality. Ischemia is a state of oxygen deprivation in tissues, whereas reperfusion is restoration of blood flow in ischemic tissues.
Vimal Agrawal, Jeetendra Kumar Gupta, Shaiba Sana Qureshi, Vishal Kumar Vishwakarma   +3 more
doaj   +1 more source

Curcumin attenuates myocardial ischemia-reperfusion injury

Oncotarget, 2017
Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world.Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated.The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ...
Liu, Kun, Chen, Honglin, You, Qing-Sheng, Ye, Qing, Wang, Fei, Wang, Shuo, Zhang, Shuang-Long, Yu, Kang-Jun, Lu, Qi   +8 more
openaire   +3 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Sex Differences in Timeliness of Reperfusion in Young Patients With ST‐Segment–Elevation Myocardial Infarction by Initial Electrocardiographic Characteristics

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundYoung women with ST‐segment–elevation myocardial infarction experience reperfusion delays more frequently than men. Our aim was to determine the electrocardiographic correlates of delay in reperfusion in young patients with ST‐segment–elevation
Aakriti Gupta, Jose A. Barrabes, Kelly Strait, Hector Bueno, Andreu Porta‐Sánchez, J. Gabriel Acosta‐Vélez, Rosa‐Maria Lidón, Erica Spatz, Mary Geda, Rachel P. Dreyer, Nancy Lorenze, Judith Lichtman, Gail D'Onofrio, Harlan M. Krumholz   +13 more
doaj   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Validation of efficacy and mechanism of Sanwei-Tanxiang powder in improving myocardial ischemia reperfusion injuries [PDF]

, 2021
Yuhui Sun, Ren Bu, Yuewu Wang, Yuchong Hu, Xumei Wang, Xin Dong, Wen Zu, Yan Niu, Pengwei Zhao, Peng Sun, Shi‐Hang Ru, Jingkun Lu, Sheng-Sang Na   +12 more
openalex   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

THE EFFECTIVENESS OF PRECONDITIONING AND POSTCONDITIONING WITH ADENOSINE IN PREVENTION OF REPERFUSION DAMAGE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION

Архивъ внутренней медицины, 2018
The study aimed to evaluate the effectiveness of pharmacological preconditioning and postconditioning with sublingual adenosine in prevention of reperfusion damage in patients with ST-segment elevation myocardial infarction.Material and methods.
N. T. Vatutin, A. N. Shevelok, V. S. Kolesnikov   +2 more
doaj   +1 more source

Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium [PDF]

, 2022
Keisuke Omiya, Yosuke Nakadate, Takeshi Oguchi, Tamaki Sato, Toru Matsuoka, Masako Abe, Akiko Kawakami, Takashi Matsukawa, Hiroaki Sato   +8 more
openalex   +1 more source

Continuous electrocardiogram monitoring in porcine model of myocardial ischemia reperfusion

Animal Models and Experimental Medicine, EarlyView.
Wearable technology for continuous electrocardiogram monitoring can be utilized in porcine models of disease. Abstract As cardiovascular disease is the leading cause of global mortality, innovative animal models are vital to demonstrating the translational value of experimental discoveries. Investigations focused on myocardial remodeling after ischemia
Nathaniel Hyams, Roxanne Swagel, Sharon Thomas, Rupak Mukherjee, Alicia Braxton Hickman, Daniel Eldridge, Kristine Helke, Ying Mei, Jean Marie Ruddy   +8 more
wiley   +1 more source