Results 111 to 120 of about 123,463 (303)

Detection of Myocardial Ischemia-Reperfusion Injury Using a Fluorescent Near-Infrared Zinc(II)-Dipicolylamine Probe and Tc Glucarate

Molecular Imaging, 2012
A fluorescent zinc 2,2′-dipicolylamine coordination complex PSVue®794 (probe 1) is known to selectively bind to phosphatidylserine exposed on the surface of apoptotic and necrotic cells.
Leonie wyffels, Brian D. Gray, Christy Barber, Koon Y. Pak, Safiyyah Forbes, Jeffrey A. Mattis, James M. Woolfenden, Zhonglin Liu   +7 more
doaj   +1 more source

Myocardial necrosis markers in myocardial ischemia reperfusion (MI/R) injury: a review

Medicine Science, 2017
Myocardial ischemia/reperfusion injury is one of the main causes of morbidity and mortality in the world. This injury is experienced by patients suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing ...
Hakan Parlakpinar, Mehmet Hamdi Orum, Onural Ozhan   +2 more
doaj   +1 more source

Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling [PDF]

, 2001
The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling ...
Jonassen, A.K., Mjøs, O.D., Sack, M.N., Yellon, D.M.   +3 more
core  

NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis. [PDF]

Cell Commun Signal, 2023
Sun W, Lu H, Cui S, Zhao S, Yu H, Song H, Ruan Q, Zhang Y, Chu Y, Dong S.   +9 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Engineered Macrophage Membrane‐Coated S100A9‐siRNA for Ameliorating Myocardial Ischemia‐Reperfusion Injury

Advanced Science
Despite the widespread adoption of emergency coronary reperfusion therapy, reperfusion‐induced myocardial injury remains a challenging issue in clinical practice.
He Lu, Junzhuo Wang, Ziwei Chen, Jing Wang, Yaohui Jiang, Zequn Xia, Ya Hou, Pingping Shang, Rutian Li, Yuyong Liu, Jun Xie   +10 more
doaj   +1 more source

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis. [PDF]

Front Immunol, 2022
Ye X, Zhang P, Zhang Y, Luan J, Xu C, Wu Z, Ju D, Hu W.   +7 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury. [PDF]

, 2019
Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury ...
Andres, Allen M, Crupi, Annunziata, Czer, Lawrence S, Esmailian, Fardad, Gottlieb, Roberta A, Hou, Jean, Marek-Iannucci, Stefanie, Mentzer, Robert M, Sin, Jon, Taylor, David J, Thomas, Amandine   +10 more
core  

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

Journal of the American College of Cardiology, 2015
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2 processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the last 3 decades, therapies to reduce ischemic injury (mainly reperfusion strategies) have been widely incorporated into clinical practice.
Ibanez, B., Heusch, G., Ovize, Michel, Werf, F.   +3 more
openaire   +3 more sources