Results 181 to 190 of about 68,817 (283)

The role of orexin A in the pathogenesis of ischaemic stroke at high altitude

Experimental Physiology, EarlyView.
Schematic illustration of the experimental design. This study investigated the role of Orexin A in the pathogenesis of ischemic stroke at high altitude. Abstract Orexin offers protection against cerebral ischaemia–reperfusion injury, with high altitude playing a key role in modulating its expression.
Minxia Zhu, Xu Guo, Jing Guo, Zhaojun Zhang, Kexin Zhang, Yaqi Lei, Yuhe Wang, Haoshuang Zhan   +7 more
wiley   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Leukocyte trafficking and myocardial reperfusion injury in ICAM-1/P-selectin-knockout mice

, 2001
Stéphanie A. Briaud, Zhi‐Ming Ding, Lloyd H. Michael, Mark L. Entman, Sherita L. Daniel, Christie M. Ballantyne   +5 more
openalex   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Myocardial ischaemia/reperfusion injury and preconditioning: effects of hypercholesterolaemia/hyperlipidaemia [PDF]

, 2003
Péter Ferdinandy
openalex   +1 more source

A pathway toward clinical translation of hyperpolarized [1,4‐13C2,2,3‐d2]fumarate as an imaging biomarker for early cellular necrosis in vivo

Magnetic Resonance in Medicine, Volume 94, Issue 3, Page 1202-1217, September 2025.
Abstract Purpose The detection of hyperpolarized carbon‐13 (HP 13C)‐fumarate conversion to 13C‐malate using 13C‐MRSI is a biomarker for early detection of cellular necrosis. Here, we describe the translation of HP 13C‐fumarate as a novel human imaging agent, including the evaluation of biocompatibility and scaling up of the hyperpolarization methods ...
Jonathan R. Birchall, Pascal Wodtke, Ashley Grimmer, Esben S. S. Hansen, Lotte B. Bertelsen, Nikolaj Bøgh, Marta Wylot, Maria J. Zamora‐Morales, Otso Arponen, Ines Horvat‐Menih, Elizabeth C. Latimer, Fung Tan, Evita Pappa, Johann Graggaber, Joseph Cheriyan, Kelly Holmes, Matthew J. Locke, Helen Sladen, Joan Boren, Mikko I. Kettunen, Anita Chhabra, Ian B. Wilkinson, Christoffer Laustsen, Kevin Brindle, Mary A. McLean, Ferdia A. Gallagher   +25 more
wiley   +1 more source

Mechanism of the Cardioprotective Effect of Inhibition of the Renin-Angiotensin System on Ischemia/Reperfusion-Induced Myocardial Injury.

, 2001
Lixing Wang, Munehito Ideishi, Eiji Yahiro, Hidenori Urata, Kikuo Arakawa, Keijiro Saku   +5 more
openalex   +2 more sources

Attenuation of increased myocardial ischaemia‐reperfusion injury conferred by hypercholesterolaemia through pharmacological inhibition of the caspase‐1 cascade [PDF]

, 2003
Tzung‐Dau Wang, Wen‐Jone Chen, Tzan‐Jr Mau, Jong‐Wei Lin, Wan‐Wan Lin, Yuan‐Teh Lee   +5 more
openalex   +1 more source

An innovative benefit‐of‐the‐doubt approach for health system effectiveness: a global case study on amenable mortality

International Transactions in Operational Research, Volume 32, Issue 5, Page 2847-2877, September 2025.
Abstract Health system performance assessment (HSPA) is essential for health planning and to improve population health. One of the HSPA domains is related to effectiveness, which can be represented considering different dimensions. Composite indicators can be used to summarize complex constructs involving several indicators. One example of such efforts
Giovanna D'Inverno, João Vasco Santos, Ana S. Camanho   +2 more
wiley   +1 more source

Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury [PDF]

, 2003
J. Vinten–Johansen
openalex   +1 more source