Results 171 to 180 of about 188,975 (215)

Cocrystallization and Micronization as Strategies to Optimize the Bioavailability of Naringin and Naringenin Molecules: A Comprehensive Review of In Vivo and In Vitro Pharmaceutical Applications

Crystal Research and Technology, Volume 61, Issue 7, July 2026.
Naringin and naringenin exhibit well‐recognized therapeutic potential; however, they face limitations related to solubility and bioavailability. Micronization increases surface area and enhances absorption. Notably, cocrystallization stands out as a primary strategy for particle optimization, as it refines physicochemical properties, improves ...
Emilia Rodrigues Almeida, Kanandra Taisa Bertoncello, Ketelin Zamin Kuhn, Liz Girardi Müller, J. Vladimir Oliveira   +4 more
wiley   +1 more source

Recipient‐derived macrophages mediate acute cardiac allograft rejection via GSDMD‐induced pyroptosis mechanism

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Recipient‐derived macrophages undergo M1‐like polarization after heart transplantation under interferon, IL‐6 and TNF‐α signalling. NF‐κB/STAT3 activation promotes GSDMD‐mediated pyroptosis and IL‐1β release in macrophages. Macrophage‐derived IL‐1β enhances CD8+T cell recruitment and activation, driving acute cardiac allograft rejection.
Bixian Luo, Zelai Wu, Chengyu Hu, Anqi Ni, Jun He, Hongming Liu, Weixun Xie, Fuping Li, Weihua Gong   +8 more
wiley   +1 more source

Unlocking the Cardioprotective Action of Human Amniotic Mesenchymal Stem Cells: A Review of the Current Documents

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Cardiovascular diseases (CVDs), such as heart failure (HF), myocardial ischemic‐reperfusion injury (MIRI), and myocardial infarction (MI), are defined as one of the most known causes of mortality and morbidity worldwide, responsible for 30% of global death rate.
Reza Arefnezhd, Farzaneh Moammer, Amirhossein Ghaneimoghadam, Shaghayegh Khodabakhshian, Sina Safdari, Reza Nasiri, Hossein Fatemian, Mohammad Reza Alipour, Seyyed Kiarash Sadat Rafiei, Fatemeh Rezaei‐Tazangi, Marziye Ranjbar Tavakoli   +10 more
wiley   +1 more source

Association of Global Longitudinal Strain With Left Ventricular Remodeling and Left Ventricular Hypertrophy in Patients With Acute Myocardial Infarction After PCI: A Small Single‐Center Prospective Observational Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Among patients with acute myocardial infarction undergoing PCI, subsequent structural alterations of the left ventricle, including left ventricular remodeling (LVR) and left ventricular hypertrophy (LVH), may contribute to later heart failure.
Bing Wang, Hong Yao, Zhijian Zhu, Zhigang Lu, Yesheng Pan   +4 more
wiley   +1 more source

Sorafenib Restores Pentose Phosphate Pathway‐Related Redox Homeostasis via the c‐Raf/HSP90/G6PD Axis in Hepatic Ischemia‐Reperfusion Injury

MedComm, Volume 7, Issue 7, July 2026.
Proposed mechanism of middle‐dose sorafenib modulates redox homeostasis via c‐Raf/HSP90/G6PD axis to attenuate hepatic IRI. This study demonstrates that middle‐dose sorafenib mitigates hepatic IRI through the c‐Raf/HSP90/G6PD axis to enhance pentose phosphate pathway‐mediated antioxidant defense and redox homeostasis, thereby alleviating inflammatory ...
Fengqiang Gao, Libin Dong, Yawen Tan, Zhen Zhang, Shengjun Xu, Zijian Lou, Yichao Wu, Siyu Chen, Li Zhuang, Zhengxing Lian, Shusen Zheng, Nasha Qiu, Kai Wang, Xiao Xu   +13 more
wiley   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

MedComm, Volume 7, Issue 7, July 2026.
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru, Patricia De Castro‐Martinez, Cielo Garcia‐Montero, Oscar Fraile‐Martinez, Majd N. Michael Alhaddadin, Silvestra Barrena‐Blázquez, Laura Lopez‐Gonzalez, Clara Tasende Fernández, Ricardo Alvarado‐Hurtado, Tomás Ratia Giménez, Inmaculada Lasa‐Unzúe, Manuel Díez Alonso, Alberto Gutiérrez‐Calvo, Miguel A. Saez, David Cobo‐Prieto, Jose V. Saz, Melchor Alvarez‐Mon, Raul Diaz‐Pedrero, Miguel A. Ortega   +18 more
wiley   +1 more source

Crataegus oxyacantha Extract Enhances Cardiac Adaptation and Reduces Oxidative‐Inflammatory Stress in Broiler Chickens Raised at High Altitude Under Cold Stress

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Crataegus oxyacantha extract at 0.4 mL/L improved cardiac function in broilers under cold stress and high altitude by increasing nitric oxide synthase gene expression, boosting nitric oxide, reducing endothelin‐1 gene expression, and lowering oxidative‐inflammatory stress, offering a natural solution to mitigate pulmonary hypertension syndrome ...
Behnam Ahmadipour, Hossein Hassanpour, Samira Abaszadeh, Majid Kalantar   +3 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Agonist vs. Placebo and Pulmonary Decline After Open‐Heart Surgery: A Substudy of the GLORIOUS Randomised Clinical Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Postoperative pulmonary decline is an established complication of open‐heart surgery extending beyond the immediate postoperative phase. Inflammation‐mediated lung damage and ischaemia‐reperfusion injury secondary to extracorporeal circulation is a proposed pathophysiological driver. GLP‐1 receptor agonists (GLP‐1RA) have emerged as
Astrid Duus Mikkelsen, Sebastian Wiberg, Hans Henrik Lawaetz Schultz, Peter Hasse Møller‐Sørensen, Dan Høfsten, Jens Christian Nilsson, Christian Holdflod Møller, Lars Køber, Christian Hassager, Jesper Kjærgaard   +9 more
wiley   +1 more source