Results 171 to 180 of about 123,463 (303)

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Identification of splenic IRF7 as a nanotherapy target for tele-conditioning myocardial reperfusion injury. [PDF]

Nat Commun
Long Q, Rabi K, Cai Y, Li L, Huang S, Qian B, Zhong Y, Qi Z, Zhang Y, Huang K, Wang X, Chang L, Xie W, Jiang H, Zhang H, Zhang J, Ren T, Wang Z, Teesalu T, Wu C, Lu L, Zhu Z, Chu Y, Santos HA, Liu Z, Zhao Q, Ye X.   +26 more
europepmc   +1 more source

The role of fluvoxamine in the treatment of endotoxin‐induced acute heart injury

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cardiovascular diseases are among the most common health problems worldwide. Inflammation plays a critical role in the pathogenesis of various heart diseases. Lipopolysaccharides (LPS) trigger inflammatory mechanisms, leading to an inflammatory response.
Ilter Ilhan, Halil Aşcı, Muhammet Yusuf Tepebasi, Nursel Hasseyid, Melih Arlıoğlu, Özlem Özmen   +5 more
wiley   +1 more source

Mitochondrial transplantation combined with mitoquinone and melatonin: A survival strategy against myocardial reperfusion injury in aged rats. [PDF]

Exp Physiol
Mokhtari B, Delkhah M, Badalzadeh R, Ghaffari S.   +3 more
europepmc   +1 more source

Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities. [PDF]

World J Cardiol, 2018
González-Montero J, Brito R, Gajardo AI, Rodrigo R.   +3 more
europepmc   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

A novel intracoronary hypothermia device reduces myocardial reperfusion injury in pigs. [PDF]

Chin Med J (Engl)
Pei Z, Qiu J, Zhao Y, Song S, Wang R, Luo W, Cai X, Liu B, Chen H, Yin J, Weng X, Wu Y, Li C, Shen L, Ge J.   +14 more
europepmc   +1 more source

Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b. [PDF]

Med Sci Monit, 2019
Wang P, Sun J, Lv S, Xie T, Wang X.
europepmc   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Circ_0001084/miR-181c-5p/PTPN4 Axis Mitigates Cardiomyocyte Injury by Modulating the TLR4/NF-κB Pathway: Insights into Therapeutic Potential for Myocardial Reperfusion Injury. [PDF]

J Inflamm Res
Deng H, Fan Q, Huang L, Ouyang W, Zhu W.
europepmc   +1 more source