Results 161 to 170 of about 188,975 (215)

Mitoquinone Prevents Cardiac Dysfunction by Normalizing Mitochondrial ROS and Calcium Handling in Acute Myocardial Infarction

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Acute myocardial infarction (MI) is the leading cause of heart failure (HF). However, the role of mitochondrial ROS (ROSm) in early MI dysfunction remains unclear. This study aimed to evaluate the impact of MitoQ on cardiac function in cases of heart HF following MI.
Carolina Falcão Ximenes, Pietra Zava Lorencini, Carmen Castardeli, Marlon Ramos Rosado Machado, Katyana Kaline Silva Ferreira, Sara Bianca Oliveira Mendes, Anna Karolina Nascimento Costa, Mario Morais Silva, Sérgio Ricardo Aluotto Scalzo, Marcos Eliezeck, Silvia Guatimosim, Eduardo Hertel Ribeiro, Donald M. Bers, Aurélia Araujo Fernandes, Ivanita Stefanon   +14 more
wiley   +1 more source

Raptor and Drp1 Function Synthetically to Control Hypoxic Death and the Mitochondrial Network in Caenorhabditis elegans

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Hypoxia results in fragmented mitochondria. Whether this fragmentation promotes or prevents cell death is unresolved. Caenorhabditis elegans mutants defective in mitochondrial fission and fusion coupled with a hypoxia resistant Raptor mutant demonstrated that hypoxia‐induced mitochondrial fragmentation occurs without an intact fission machinery and ...
Julien Goldstick, Diego Compte, Chun‐Ling Sun, Alison E. Ritter, C. Michael Crowder   +4 more
wiley   +1 more source

Synthetic Ligands of Myeloid C‐Type Lectin Receptors

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley   +1 more source

Temporal Trends and Short‐ and Long‐Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study

Arthritis Care &Research, Volume 78, Issue 7, Page 850-859, July 2026.
Objective We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analyzed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalized with AMI between 2005 and 2019 from the Myocardial Ischaemia ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A. Mamas   +8 more
wiley   +1 more source

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, Volume 10, Issue 4, Page 1356-1364, July 2026.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source

Adjunctive Minocycline in Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Brain and Behavior, Volume 16, Issue 7, July 2026.
ABSTRACT Background Acute ischemic stroke (AIS) is a leading cause of mortality and long‐term disability worldwide. Despite advances in acute stroke management, many patients continue to experience substantial neurological disability and incomplete recovery.
Samaha Khalid, Malik Aon Ali Abbas, Muhammad Sohaib Shahid, Muhammad Nihal Moarij Azeem Malik, Mahnoor Javed, Abdur Rehman, Saad Ashraf, Muhammad Daoud Tariq, Deepak Rai   +8 more
wiley   +1 more source

Prognostic Factors in Acute Ischemic Stroke With a Decreased Estimated Glomerular Filtration Rate

Brain and Behavior, Volume 16, Issue 7, July 2026.
ABSTRACT Introduction Intra‐arterial thrombectomy (IAT), which is widely used to treat acute ischemic stroke, occasionally results in adverse outcomes. IAT‐associated risks in patients with decreased estimated glomerular filtration rate (eGFR) remain undefined.
Chang Hyeon Kim, Hyun Uk Lee, Byoung‐Soo Shin, Hyun Goo Kang   +3 more
wiley   +1 more source

Influence of the Residual Gensini Score on Prognosis of Patients With ST‐Elevation Myocardial Infarction

Catheterization and Cardiovascular Interventions, Volume 108, Issue 1, Page 76-83, July 1, 2026.
ABSTRACT Background The residual Gensini score (rGS) was developed to quantify the severity of coronary atheroma burden after coronary revascularisation. The predictive value of the rGS for clinical outcomes in patients with ST‐segment elevation myocardial infarction (STEMI) remains unexplored.
Batric Popovic, Nassima Djaballah, Mirela Tomic, Renaud Fay, Victorine Fraichot, Florian Eggenspieler, Pierre Adrien Metzdorf, Jeanne Varlot, Edoardo Camenzind   +8 more
wiley   +1 more source

Potential Mechanisms of Trimetazidine and Coenzyme Q10 Against Antipsychotic‐Induced Myocarditis: A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
In this study, we explored the mechanisms for the therapeutic effects of TMZ and CoQ10 on myocarditis using network pharmacology, molecular docking, and molecular dynamics simulations. Our findings identified core targets of TMZ and CoQ10 treatment of myocarditis; the five core targets included EGFR, MMP9, PPARG, AKT1, and CASP3.
Ximing Chen, Dongyin Zhuo, Jiatong Zou, Haitao Song, Kaifang Yao, Hongjun Tian, Chuanjun Zhuo   +6 more
wiley   +1 more source

Plasma Metabolomics of Thrombectomy‐Treated Patients Highlights Metabolic Pathways Underlying Disease and Recovery

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Untargeted plasma metabolomics reveals distinct metabolic signatures distinguishing thrombosis patients with successful vs. failed recovery after recanalization. Altered pathways involving mitochondrial function, lipid metabolism, amino‐acid utilization, and inflammation highlight potential biomarkers and therapeutic targets for monitoring disease ...
Min Cai, Xiangyu Hou, Shilong Deng, Wenxin Shen, Dingzhi Gao, Xinyu Zhang, Siyuan Fan, Yongliang Xia, Yuanlin Ma, Ke Cheng   +9 more
wiley   +1 more source