Results 151 to 160 of about 1,258,622 (242)

Integrative simulation analysis of myocardial ischaemia–reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend A comprehensive mathematical model of ventricular myocyte was developed to gain insights into the mechanisms underlying cardiac ischaemia–reperfusion injury. The model integrates excitation–contraction (E–C) coupling, cytosolic and mitochondrial pH regulation, pH dependence of major E–C coupling components and cellular energy ...
Takao Shimayoshi, Ayako Takeuchi, Satoshi Matsuoka   +2 more
wiley   +1 more source

Intraoperative Dynamics of Lactate, pH, and Bicarbonate During Cardiac Surgery: A Prospective Study Exploring a Composite Metabolic Marker of Reperfusion Stress. [PDF]

Diagnostics (Basel)
Raicea A, Moraru L, Raicea V.
europepmc   +1 more source

Amyloid‐Forming Amylin Secreted by the Pancreas Promotes Hypoxia‐Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Human amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Alice E. Knapton, Nirmal Verma, Deepak Kotiya, Alice P. Sowton, Benjamin D. Thackray, Lorenz M. W. Holzner, Paula M. Darwin, Sanda Despa, Florin Despa, Andrew J. Murray   +9 more
wiley   +1 more source

Retraction: Long noncoding RNA-MEG3 contributes to myocardial ischemia-reperfusion injury through suppression of miR-7-5p expression. [PDF]

Biosci Rep
Zou L, Ma X, Lin S, Wu B, Chen Y, Peng C.   +5 more
europepmc   +1 more source

Lung‐Cardiovascular Interactions and Derangements in ARDS

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Pablo A. Sanchez, Connor O'Brien, Matthieu Legrand, Carolyn S. Calfee, Michael A. Matthay   +4 more
wiley   +1 more source

Mapping the Inflammation Research Landscape in Myocardial Infarction, 1995-2025: A Bibliometric Analysis of WoSCC and PubMed. [PDF]

J Inflamm Res
Liu Y, Chen S, Li T, Hu Y, Lin Z, Fu Y, Fu Z.   +6 more
europepmc   +1 more source

Simultaneous 3‐D Adiabatic T1ρ, T2*, and Quantitative Susceptibility Mapping for Characterization of Myocardial Infarction in Ex Vivo Mouse

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
This study combines segmented T1ρ preparation into a 3‐D gradient‐echo sequence for simultaneous quantitative susceptibility, T2*, and T1ρ mapping of infarcted mouse hearts ex vivo. The method enabled assessment of T1ρ and T2* relaxation time maps and magnetic susceptibility, with ischemic regions clearly identified by all contrasts and consistent with
Iida Räty, Olli Nykänen, Sanna Kettunen, Svetlana Laidinen, Anna‐Kaisa Ruotsalainen, Mikko J. Nissi, Elias Ylä‐Herttuala   +6 more
wiley   +1 more source

Curcumin in ischemia-reperfusion injury across multiple organs: A review. [PDF]

J Int Med Res
Lu J, Fang X, Wei X, Xu X.
europepmc   +1 more source

Mechanism of Yangxin Dawa Yimixike Mi Gao for myocardial ischemia/reperfusion injury: an integrative study of network pharmacology and and validation. [PDF]

J Tradit Chin Med
Yuwei D, Qingzhi R, Rahima A, Maiwulanjiang M, Fang T, Haji Akber A.   +5 more
europepmc   +1 more source

Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek, Roos Buds, Ingrid Dijkgraaf, Pedro E. Marques   +3 more
wiley   +1 more source