Results 181 to 190 of about 188,975 (215)

A Non‐Channel Function of CFTR: Attenuating Mitochondrial Oxidative Stress and Cardiomyocyte Senescence via Stabilization by USP45

Aging Cell, Volume 25, Issue 7, July 2026.
USP45 stabilizes CFTR through deubiquitination, thereby activating PMCA, which inhibits calcium/chloride overload and mitochondrial oxidative stress in senescent cardiomyocytes, ultimately alleviating cardiomyocyte senescence. ABSTRACT Cardiomyocyte senescence drives cardiovascular disease, underscoring the need to define its molecular mechanisms.
Chun Chen, Longtan Jiang, Yuewen Qiu, Chong Liu, Xiao Long, Pengcui Wu, Liang Li, Haixia Xu, Ping Deng, Li Yang, Qiao Jin   +10 more
wiley   +1 more source

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Myocardial Reperfusion Injury

New England Journal of Medicine, 2007
Derek J Hausenloy, Yellon Derek M, Hausenloy Derek J   +2 more
exaly   +2 more sources

Cellular mechanisms and pathways in myocardial reperfusion injury

Coronary Artery Disease, 2021
Despite the progress of cardiovascular medicine, ischemia-reperfusion injury can contribute to increased mortality and prolonged hospitalization after myocardial infarction.
Ioannis Valikeserlis, Amaryllis-Aikaterini Athanasiou, D. Stakos   +2 more
semanticscholar   +1 more source

Regulated cell death in myocardial ischemia-reperfusion injury.

Trends in endocrinology and metabolism, 2023
Myocardial ischemia-reperfusion (I/R) injury most commonly occurs in coronary artery disease when prompt reperfusion is used to salvage the ischemic myocardium. Cardiomyocyte death is a significant component of myocardial I/R injury and its mechanism was
Qi Xiang, Xin Yi, Xue-Hai Zhu, Xiang Wei, D. Jiang   +4 more
semanticscholar   +1 more source

The role of PI3K/AKT signaling pathway in myocardial ischemia-reperfusion injury.

International Immunopharmacology, 2023
Myocardial ischemia has a high incidence and mortality rate, and reperfusion is currently the standard intervention. However, reperfusion may lead to further myocardial damage, known as myocardial ischemia/reperfusion injury (MIRI).
Rui Deng, Juan Zhou
semanticscholar   +1 more source

'Myocardial Ischemia-Reperfusion Injury and the Influence of Inflammation.

Trends in cardiovascular medicine, 2022
Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to ischemia in the corresponding myocardial territory which generally results in myocardial necrosis.
M. Algoet, S. Janssens, U. Himmelreich, W. Gsell, M. Pusovnik, J. van den Eynde, W. Oosterlinck   +6 more
semanticscholar   +1 more source

Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention.

Microvascular Research, 2023
Cardiovascular diseases are one of the leading causes of mortality in developed countries. Among cardiovascular disorders, myocardial infarction remains a life-threatening problem predisposing to the development and progression of ischemic heart failure.
Yang Liu, Xi-luan Ji, Zhou Zhou, Jingwen Zhang, Juan Zhang   +4 more
semanticscholar   +1 more source

STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation

Signal Transduction and Targeted Therapy
Despite advancements in interventional coronary reperfusion technologies following myocardial infarction, a notable portion of patients continue to experience elevated mortality rates as a result of myocardial ischemia-reperfusion (MI/R) injury.
Xiaohong Wang, Tao Chen, Sizhe Chen, Jie Zhang, Liangyu Cai, Changhao Liu, Yujie Zhang, Xiao Wu, Na Li, Zhiyong Ma, Lei Cao, Qian Li, Chenghu Guo, Qiming Deng, Wenqian Qi, Yonghao Hou, Ruiqing Ren, Wenhai Sui, Haonan Zheng, Yun Zhang, Meng Zhang, Cheng Zhang   +21 more
semanticscholar   +1 more source

Reperfusion Injury in Patients With Acute Myocardial Infarction: JACC Scientific Statement.

Journal of the American College of Cardiology
Despite impressive improvements in the care of patients with ST-segment elevation myocardial infarction, mortality remains high. Reperfusion is necessary for myocardial salvage, but the abrupt return of flow sets off a cascade of injurious processes that
F. Welt, Wayne B. Batchelor, J. Spears, C. Penna, P. Pagliaro, B. Ibáñez, Stavros G. Drakos, G. Dangas, Navin K. Kapur   +8 more
semanticscholar   +1 more source

Role of epigenetic regulation in myocardial ischemia/reperfusion injury.

Pharmacological Research, 2021
Nowadays acute myocardial infarction (AMI) is a serious cardiovascular disease threatening the human life and health worldwide. The most effective treatment is to quickly restore coronary blood flow through revascularization.
Keyan Wang, Yiping Li, Ting-ting Qiang, Jie Chen, Xiaolong Wang   +4 more
semanticscholar   +1 more source